The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Bdkrb1  -  bradykinin receptor, beta 1

Mus musculus

Synonyms: B1 bradykinin receptor, B1BKR, B1R, BK-1 receptor, BKR1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Bdkrb1

  • Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier [1].
  • These findings support other evidence for an involvement of B1 receptors in inflammatory hyperalgesia and suggest that B1 receptor antagonists may be clinically useful as anti-inflammatory and analgesic drugs [2].
  • Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice [3].
  • These data show that the long-term systemic treatment of mice with BCG produced dose-related potentiation of B1 receptor agonist-mediated nociception and oedema formation, without affecting similar responses caused by the B2 receptor agonist tyrosine8-bradykinin [3].
  • The kinin B1 receptor antagonist [Leu8]des-Arg9-bradykinin or the B2 antagonist d-Arg[Hyp3,Thi5,D-Tic7, Oic8]bradykinin (HOE-140) was injected subcutaneously into STZ mice at 300 micrograms/kg body weight twice a day and 500 micrograms/kg per day, respectively [4].

High impact information on Bdkrb1

  • The stimulatory effect of TK was mimicked by bradykinin (BK) and could be reversed by application of JE049, a BK receptor type 2 antagonist [5].
  • The B1 receptor is a heptahelical receptor distinct from the B2 receptor in that it is highly inducible by inflammatory mediators such as bacterial lipopolysaccharide and interleukins [6].
  • Thus, the kinin B1 receptor plays an essential physiological role in the initiation of inflammatory responses and the modulation of spinal cord plasticity that underlies the central component of pain [6].
  • Using whole-cell patch-clamp recordings, we show that the B1 receptor was not necessary for regulating the noxious heat sensitivity of isolated nociceptors [6].
  • No atypic high-affinity binding sites for the B1 receptor agonist des-Arg9-BK could be observed [7].

Chemical compound and disease context of Bdkrb1

  • The contributions of B1 and B2 bradykinin receptors to acute and chronic inflammatory hyperalgesia were examined using the peptide B1 receptor antagonist des-Arg9[Leu8]bradykinin and transgenic Bk2r-/- mice [2].

Biological context of Bdkrb1


Anatomical context of Bdkrb1

  • Whereas B1R is barely detected in most brain regions, B2R is extensively distributed, displaying the highest densities in the hindbrain [1].
  • The contraction induced by desArg9BK had a longer duration than that evoked by BK and increased during incubation in vitro in stomachs of wild-type controls, while in the transgenic B2 receptor knockout mice, the contractions evoked by desArg9BK and BK were similar and followed the B1 receptor agonist pattern [10].
  • Taken together, these data suggest a deleterious effect for kinin B1 receptor and a protective effect for kinin B2 receptor during the development of the temporal lobe epilepsy [11].
  • In this report, we describe oocyte expression experiments showing that the B1 receptor in WI38 human fibroblast cells is encoded by a distinct mRNA approximately 2 kb shorter than that encoding the B2 receptor [12].
  • Evidence for in vitro expression of B1 receptor in the mouse trachea and urinary bladder [13].

Associations of Bdkrb1 with chemical compounds

  • Bradykinin normally exerts its vasodilatory effect via the B2 receptor (B2R), but in this receptor's absence, the B1 receptor becomes expressed and activated [8].
  • Injection with the B1R agonist produced a hypotensive response (12+/-1.3 mm Hg), which was further accentuated by TxA2 blockade (21.7+/-4.1 mm Hg) [8].
  • Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy [11].
  • Bk-induced prostaglandin synthesis in isolated osteoblast-like cells and in MC3T3-E1 cells was inhibited by D-Arg0[Hyp3,Thi5,8,D-Phe7]-Bk, whereas the B1 Bk receptor antagonist des-Arg9-Leu8-Bk had no effect [14].
  • The B2 Bk receptor agonists Bk and Lys-Bk, but not the B1 Bk receptor agonist des-Arg9-Bk, caused a rapid burst (5 minutes) of prostaglandin E2 and prostacyclin formation in isolated osteoblast-like cells from neonatal mouse calvarial bones and in the murine osteoblastic cell lineage MC3T3-E1 [14].

Regulatory relationships of Bdkrb1

  • We conclude that GDNF and neurturin potently upregulate functional B1 receptor expression in small non-peptidergic nociceptive neurones [15].

Other interactions of Bdkrb1

  • Expression of the TxA2 receptor gene in renal tissue by quantitative real-time PCR was significantly lower in mice treated with the B1R antagonist, consistent with increased levels of agonist for this receptor [8].
  • B 1 receptor transcription activation in response to LPS was abolished by cotransfection with IkappaBalphaDeltaN, an NF-kappaB repressor [16].
  • These results suggest that in single NG108-15 cells, EK induces Ca2+ mobilization which is assisted by cross-talk between the EK and BK receptor systems via a pertussis toxin-sensitive G protein [17].

Analytical, diagnostic and therapeutic context of Bdkrb1

  • In a first step to better understand how BK and its receptors could be involved in such a large variety of biological effects, we used microarray analysis to identify, under physiological conditions, the global renal gene expression profile in mice lacking either the kinin B1 or B2 receptor [9].
  • Finally, a RT-PCR technique showed an activation of kinin B1 receptor gene transcription, in wild type hearts, subjected to the ischemia-reperfusion sequence [18].
  • No change in urinary Ca excretion was observed in B2-/- mice, even after treatment with a kinin B1-receptor antagonist, and these mice adapted normally to the LCa diet [19].
  • METHODS: We investigated the effect and mechanisms of tissue kallikrein using hypertrophic animal models of rats as well as mice deficient in kinin B1 or B2 receptor after aortic constriction (AC) [20].
  • 4. Northern blot hybridization with a specific cDNA probe against mouse B1 receptor mRNA using total RNA extracted from tracheae and urinary bladders freshly removed from Swiss and Bk2r(-/-) mice revealed minimal expression [13].


  1. Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier. Ongali, B., Hellal, F., Rodi, D., Plotkine, M., Marchand-Verrecchia, C., Pruneau, D., Couture, R. J. Neurotrauma (2006) [Pubmed]
  2. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice. Rupniak, N.M., Boyce, S., Webb, J.K., Williams, A.R., Carlson, E.J., Hill, R.G., Borkowski, J.A., Hess, J.F. Pain (1997) [Pubmed]
  3. Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice. de Campos, R.O., Henriques, M.G., Calixto, J.B. Neuropeptides (1998) [Pubmed]
  4. Effects of B1 and B2 kinin receptor antagonists in diabetic mice. Zuccollo, A., Navarro, M., Catanzaro, O. Can. J. Physiol. Pharmacol. (1996) [Pubmed]
  5. Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5. Gkika, D., Topala, C.N., Chang, Q., Picard, N., Th??bault, S., Houillier, P., Hoenderop, J.G., Bindels, R.J. EMBO J. (2006) [Pubmed]
  6. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva, J.A., Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C., Calixto, J.B., Lewin, G.R., Bader, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. [3H]bradykinin receptor-binding, receptor-recycling, and receptor-internalization of the B2 bradykinin receptor in the murine osteoblast-like cell line MC3T3-E1. Windischhofer, W., Leis, H.J. J. Bone Miner. Res. (1997) [Pubmed]
  8. Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Duka, I., Duka, A., Kintsurashvili, E., Johns, C., Gavras, I., Gavras, H. Hypertension (2003) [Pubmed]
  9. Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes. Bachvarov, D., Bachvarova, M., Koumangaye, R., Klein, J., Pesquero, J.B., Neau, E., Bader, M., Schanstra, J.P., Bascands, J.L. Biol. Chem. (2006) [Pubmed]
  10. Effects of kinins on isolated stomachs of control and transgenic knockout B2 receptor mice. Nsa Allogho, S., Gobeil, F., Perron, S.I., Hess, J.F., Regoli, D. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
  11. Role of kinin B1 and B2 receptors in the development of pilocarpine model of epilepsy. Adolfo Argañaraz, G., Regina Perosa, S., Cristina Lencioni, E., Bader, M., Abrão Cavalheiro, E., da Graça Naffah-Mazzacoratti, M., Pesquero, J.B., Antônio Silva, J. Brain Res. (2004) [Pubmed]
  12. B1 and B2 bradykinin receptors encoded by distinct mRNAs. Webb, M., McIntyre, P., Phillips, E. J. Neurochem. (1994) [Pubmed]
  13. Evidence for in vitro expression of B1 receptor in the mouse trachea and urinary bladder. Trevisani, M., Schmidlin, F., Tognetto, M., Nijkamp, F.P., Gies, J.P., Frossard, N., Amadesi, S., Folkerts, G., Geppetti, P. Br. J. Pharmacol. (1999) [Pubmed]
  14. Bradykinin-induced burst of prostaglandin formation in osteoblasts is mediated via B2 bradykinin receptors. Ljunggren, O., Vavrek, R., Stewart, J.M., Lerner, U.H. J. Bone Miner. Res. (1991) [Pubmed]
  15. Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF. Vellani, V., Zachrisson, O., McNaughton, P.A. J. Physiol. (Lond.) (2004) [Pubmed]
  16. Molecular structure and transcriptional regulation by nuclear factor-kappaB of the mouse kinin B1 receptor gene. Merino, V.F., Silva, J.A., Araújo, R.C., Avellar, M.C., Bascands, J.L., Schanstra, J.P., Paiva, A.C., Bader, M., Pesquero, J.B. Biol. Chem. (2005) [Pubmed]
  17. Enkephalin induces Ca2+ mobilization in single cells of bradykinin-sensitized differentiated neuroblastoma hybridoma (NG108-15) cells. Tomura, H., Okajima, F., Kondo, Y. Neurosci. Lett. (1992) [Pubmed]
  18. Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice. Lagneux, C., Bader, M., Pesquero, J.B., Demenge, P., Ribuot, C. Int. Immunopharmacol. (2002) [Pubmed]
  19. Tissue kallikrein-deficient mice display a defect in renal tubular calcium absorption. Picard, N., Van Abel, M., Campone, C., Seiler, M., Bloch-Faure, M., Hoenderop, J.G., Loffing, J., Meneton, P., Bindels, R.J., Paillard, M., Alhenc-Gelas, F., Houillier, P. J. Am. Soc. Nephrol. (2005) [Pubmed]
  20. Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. Li, H.J., Yin, H., Yao, Y.Y., Shen, B., Bader, M., Chao, L., Chao, J. Cardiovasc. Res. (2007) [Pubmed]
WikiGenes - Universities