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Gene Review:

Lscc1 - lung squamous cell carcinoma 1

Mus musculus

Shitara, K. et al., Hanai, N. et al., Yano, S. et al., Hirabayashi, K. et al., Ogawa, H. et al., et al.

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Disease relevance of Lscc1

Two monoclonal antibodies, KM-32 and KM-34, were developed from mice immunized with lung squamous cell carcinoma tissues and two other monoclonal antibodies, KM-52 and KM-93, were developed from mice immunized with lung adenocarcinoma tissues [1].
In immunoperoxidase staining, KM-93 reacted strongly and frequently with tumor cells of lung adenocarcinoma and partially with those of lung squamous cell carcinoma, large cell carcinoma, and small cell carcinoma [2].
Colon carcinoma (KM12SM) and lung adenocarcinoma (PC14PE6 and PC14Br) cells produced large, fast-growing parenchymal brain metastases, whereas lung squamous cell carcinoma (H226), renal cell carcinoma (SN12PM6), and melanoma (TXM13) cells produced only a few slow-growing brain metastases [3].
The effect of tranexamic acid on the growth of three human tumor cell lines (lung squamous cell carcinoma QG-56, lung adenocarcinoma PC-12 and ovarian carcinoma OC-1) was investigated in vitro and in vivo in nude mice [4].

High impact information on Lscc1

To investigate the possible role of syndecan-1 in cell proliferation and metastatic potential, we employed a highly metastatic cell line (KLN 205) derived from mouse lung squamous cell carcinoma that expressed moderate amounts of syndecan-1 [5].
Lung squamous cell carcinoma producing both parathyroid hormone-related peptide and granulocyte colony stimulating factor [6].

Chemical compound and disease context of Lscc1

KM-34 and KM-52 detected protein or glycoprotein antigens and they showed predominant reactivity to lung squamous cell carcinoma and lung adenocarcinoma, respectively [1].

Anatomical context of Lscc1

Serum with a high KA432/227 level was most frequently found in lung adenocarcinoma (47.8%), and occasionally found in lung squamous cell carcinoma (23.1%), lung large cell carcinoma (22.2%), pancreatic carcinoma (20.0%) and carcinoma of the bile-duct and the gall bladder (25.0%) [7].

Analytical, diagnostic and therapeutic context of Lscc1

The two Ab2 beta antibodies, 2B12 and 2H1, express internal images of lung squamous cell carcinoma recognized by the 4G12 antibody and may be useful for cancer immunotherapy [8].
In the present work the biodistribution of radiolabelled Po66 and of an unrelated immunoglobulin were studied comparatively after intravenous injection into nude mice bearing lung squamous cell carcinoma grafts [9].
Two monoclonal antibodies, KM227 (IgM) and KM432 (IgG1), were established by immunizing mice with the crude membrane fraction of lung squamous cell carcinoma and the high-molecular-weight antigen in pleural perfusion from patients with lung adenocarcinoma, respectively [7].

References

Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung. Hanai, N., Shitara, K., Yoshida, H. Cancer Res. (1986) [Pubmed]
Distribution of lung adenocarcinoma-associated antigens in human tissues and sera defined by monoclonal antibodies KM-52 and KM-93. Shitara, K., Hanai, N., Yoshida, H. Cancer Res. (1987) [Pubmed]
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis. Yano, S., Shinohara, H., Herbst, R.S., Kuniyasu, H., Bucana, C.D., Ellis, L.M., Davis, D.W., McConkey, D.J., Fidler, I.J. Cancer Res. (2000) [Pubmed]
Effect of antifibrinolysis treatment on human cancer in nude mice. Ogawa, H., Sekiguchi, F., Tanaka, N., Ono, K., Tanaka, K., Kinjo, M., Iwakawa, A., Naito, S. Anticancer Res. (1982) [Pubmed]
Altered proliferative and metastatic potential associated with increased expression of syndecan-1. Hirabayashi, K., Numa, F., Suminami, Y., Murakami, A., Murakami, T., Kato, H. Tumour Biol. (1998) [Pubmed]
Lung squamous cell carcinoma producing both parathyroid hormone-related peptide and granulocyte colony stimulating factor. Furihata, M., Sonobe, H., Iwata, J., Ido, E., Ohtsuki, Y., Asahi, Y., Kubonishi, I., Miyoshi, I. Pathol. Int. (1996) [Pubmed]
Detection of a novel lung adenocarcinoma--associated serum antigen defined by two monoclonal antibodies, KM 432 and KM 227. Shitara, K., Hanai, N., Yoshida, H. Anticancer Res. (1993) [Pubmed]
Establishment of internal-image anti-idiotype monoclonal antibodies to a human antibody to lung cancer. Saito, H., Taniguchi, M., Fukasawa, T., Yamaguchi, Y., Fujisawa, T. Cancer Immunol. Immunother. (1997) [Pubmed]
Distribution of radiolabelled monoclonal antibody Po66 after intravenous injection into nude mice bearing human lung cancer grafts. Desrues, B., Collet, B., Ramé, M.P., Bourel, D., Bourguet, P., Martin, A., Delaval, P., Toujas, L., Dazord, L. Cancer Immunol. Immunother. (1989) [Pubmed]

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