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Gene Review

Sdc1  -  syndecan 1

Mus musculus

Synonyms: AA408134, AA409076, CD138, SYND1, Sstn, ...
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Disease relevance of Sdc1


Psychiatry related information on Sdc1

  • Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3 [6].

High impact information on Sdc1


Chemical compound and disease context of Sdc1

  • We show in this study that syndecan-1, the major heparan sulfate proteoglycan of epithelial cells, attenuates allergic lung inflammation [8].
  • Our results show that syndecan-1-null mice instilled with allergens exhibit exaggerated airway hyperresponsiveness, glycoprotein hypersecretion, eosinophilia, and lung IL-4 responses [8].
  • Sdc1-/- mice administered DMBA during juvenile development are resistant not only to epithelial tumors, including liver (60-80%) and lung tumors (C57BL6 mice, 60-80%), but also to lymphoma (over 70%, depending upon strain and carcinogen dose) [9].

Biological context of Sdc1

  • FKBP gene expression coordinately induces the expression of the antiinvasive Sdc1 gene and suppresses the proinvasive MMP9 gene [10].
  • Thus, the response of Sdc1-/- mammary epithelial cells (mecs) to the intracellular, activated Wnt signal transducer, DeltaNbeta-catenin, was assayed both in vitro and in vivo, to test whether beta-catenin/TCF transactivation was Sdc1-independent [11].
  • These data indicate that the expression of fibroglycan occurs along unique and developmentally regulated patterns, and suggest that fibroglycan and syndecan-1 may have distinctive functions during tissue morphogenesis and differentiation [12].
  • Examination of cultured breast carcinoma cell lines indicates that they also display the phenotype of the syndecan-1 positive tumors and thereby provide a model system for analysis of intracellular syndecan-1 [13].
  • Chromosome mapping of the murine syndecan gene [14].

Anatomical context of Sdc1

  • Thus, matrilysin-mediated shedding of syndecan-1/KC complexes from the mucosal surface directs and confines neutrophil influx to sites of injury [2].
  • In limb buds and facial processes, MK, HB-GAM, and syndecan-1 were localized to the apical epithelium and the adjacent proliferating mesenchyme [15].
  • We show that syndecan-1, -3, and -4 are expressed in developing skeletal muscle tissue and that syndecan-3 and -4 expression is highly restricted in adult skeletal muscle to cells retaining myogenic capacity [16].
  • All cell lines examined express syndecan-1, and poorly differentiated lines such as BT549 cells internalize the proteoglycan from the cell surface where it accumulates as intact HSPG in intracellular vesicles [13].
  • Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells [13].

Associations of Sdc1 with chemical compounds

  • Both MK and HB-GAM bound syndecan-1 in solid-phase assays in a heparan sulfate-dependent manner [15].
  • A comparative analysis was carried out of heparan sulfate (HS) and chondroitin sulfate (CS) chains of the ectodomains of hybrid type transmembrane proteoglycans, syndecan-1 and -4, synthesized simultaneously by normal murine mammary gland epithelial cells [17].
  • Lysosomal inactivation using ammonium chloride demonstrates that well-differentiated lines such as T47D and MCF-7 cells, which maintain the majority of syndecan-1 on their cell surfaces, also target intact constitutively endocytosed syndecan-1 to lysosomes [13].
  • Dibutyryl cAMP does not induce syndecan-1 expression in resident peritoneal macrophages, which lack a pool of stored mRNA [18].
  • The homologous peptides, which promote either integrin- or syndecan-mediated cell attachment, may be useful for understanding the cell type- and chain-specific biological activities of the laminins [19].
  • Our results identify TGFbeta1 signaling and Sdc1 expression as important factors regulating integrin surface expression, activity and migration in keratinocyte and provide new insight into the functions regulated by Sdc1 [20].

Physical interactions of Sdc1


Regulatory relationships of Sdc1


Other interactions of Sdc1

  • Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice [1].
  • Taken together these results indicate that MK and HB-GAM may play regulatory roles in differentiation and morphogenesis of the vertebrate embryo, particularly in epithelio-mesenchymal organs, and suggest molecular interactions with syndecan-1 [15].
  • The distribution patterns of FGFR1 and PTN overlapped considerably with those of syndecan-1 and -3 mRNAs, respectively [4].
  • Compared with syndecan-4 expression, syndecan-1 and -3 are expressed more abundantly in postovulatory follicles and the corpora lutea, but less in the type 4-5b follicles and much less in the atretic follicles [28].
  • Expression of Msx-1 and Msx-2, growth factors and syndecan continues into the condensation phase [24].

Analytical, diagnostic and therapeutic context of Sdc1


  1. Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Alexander, C.M., Reichsman, F., Hinkes, M.T., Lincecum, J., Becker, K.A., Cumberledge, S., Bernfield, M. Nat. Genet. (2000) [Pubmed]
  2. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Li, Q., Park, P.W., Wilson, C.L., Parks, W.C. Cell (2002) [Pubmed]
  3. Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion. Reiland, J., Sanderson, R.D., Waguespack, M., Barker, S.A., Long, R., Carson, D.D., Marchetti, D. J. Biol. Chem. (2004) [Pubmed]
  4. Increased syndecan expression by pleiotrophin and FGF receptor-expressing astrocytes in injured brain tissue. Iseki, K., Hagino, S., Mori, T., Zhang, Y., Yokoya, S., Takaki, H., Tase, C., Murakawa, M., Wanaka, A. Glia (2002) [Pubmed]
  5. Syndecan-1 is an in vivo suppressor of Gram-positive toxic shock. Hayashida, K., Chen, Y., Bartlett, A.H., Park, P.W. J. Biol. Chem. (2008) [Pubmed]
  6. Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Reizes, O., Lincecum, J., Wang, Z., Goldberger, O., Huang, L., Kaksonen, M., Ahima, R., Hinkes, M.T., Barsh, G.S., Rauvala, H., Bernfield, M. Cell (2001) [Pubmed]
  7. Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Park, P.W., Pier, G.B., Hinkes, M.T., Bernfield, M. Nature (2001) [Pubmed]
  8. Endogenous attenuation of allergic lung inflammation by syndecan-1. Xu, J., Park, P.W., Kheradmand, F., Corry, D.B. J. Immunol. (2005) [Pubmed]
  9. Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. McDermott, S.P., Ranheim, E.A., Leatherberry, V.S., Khwaja, S.S., Klos, K.S., Alexander, C.M. Oncogene (2007) [Pubmed]
  10. Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family. Fong, S., Mounkes, L., Liu, Y., Maibaum, M., Alonzo, E., Desprez, P.Y., Thor, A.D., Kashani-Sabet, M., Debs, R.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Mammary gland development requires syndecan-1 to create a beta-catenin/TCF-responsive mammary epithelial subpopulation. Liu, B.Y., Kim, Y.C., Leatherberry, V., Cowin, P., Alexander, C.M. Oncogene (2003) [Pubmed]
  12. Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development. David, G., Bai, X.M., Van der Schueren, B., Marynen, P., Cassiman, J.J., Van den Berghe, H. Development (1993) [Pubmed]
  13. Syndecan-1 accumulates in lysosomes of poorly differentiated breast carcinoma cells. Burbach, B.J., Friedl, A., Mundhenke, C., Rapraeger, A.C. Matrix Biol. (2003) [Pubmed]
  14. Chromosome mapping of the murine syndecan gene. Oettinger, H.F., Streeter, H., Lose, E., Copeland, N.G., Gilbert, D.J., Justice, M.J., Jenkins, N.A., Mohandas, T., Bernfield, M. Genomics (1991) [Pubmed]
  15. Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Mitsiadis, T.A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M., Thesleff, I. Development (1995) [Pubmed]
  16. Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Cornelison, D.D., Filla, M.S., Stanley, H.M., Rapraeger, A.C., Olwin, B.B. Dev. Biol. (2001) [Pubmed]
  17. Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. Deepa, S.S., Yamada, S., Zako, M., Goldberger, O., Sugahara, K. J. Biol. Chem. (2004) [Pubmed]
  18. Post-transcriptional regulation of syndecan-1 expression by cAMP in peritoneal macrophages. Yeaman, C., Rapraeger, A.C. J. Cell Biol. (1993) [Pubmed]
  19. Biological activities of homologous loop regions in the laminin alpha chain G domains. Suzuki, N., Nakatsuka, H., Mochizuki, M., Nishi, N., Kadoya, Y., Utani, A., Oishi, S., Fujii, N., Kleinman, H.K., Nomizu, M. J. Biol. Chem. (2003) [Pubmed]
  20. Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. Stepp, M.A., Liu, Y., Pal-Ghosh, S., Jurjus, R.A., Tadvalkar, G., Sekaran, A., Losicco, K., Jiang, L., Larsen, M., Li, L., Yuspa, S.H. J. Cell. Sci. (2007) [Pubmed]
  21. Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1. Mali, M., Elenius, K., Miettinen, H.M., Jalkanen, M. J. Biol. Chem. (1993) [Pubmed]
  22. Growth factors induce 3T3 cells to express bFGF-binding syndecan. Elenius, K., Määttä, A., Salmivirta, M., Jalkanen, M. J. Biol. Chem. (1992) [Pubmed]
  23. Thrombin stimulates syndecan-1 promotor activity and expression of a form of syndecan-1 that binds antithrombin III in vascular smooth muscle cells. Cizmeci-Smith, G., Carey, D.J. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  24. Divide, accumulate, differentiate: cell condensation in skeletal development revisited. Hall, B.K., Miyake, T. Int. J. Dev. Biol. (1995) [Pubmed]
  25. Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells. Kato, M., Saunders, S., Nguyen, H., Bernfield, M. Mol. Biol. Cell (1995) [Pubmed]
  26. Syndecan-1 expression is down-regulated during myoblast terminal differentiation. Modulation by growth factors and retinoic acid. Larraín, J., Cizmeci-Smith, G., Troncoso, V., Stahl, R.C., Carey, D.J., Brandan, E. J. Biol. Chem. (1997) [Pubmed]
  27. Epithelial-mesenchymal interactions in uterus and vagina alter the expression of the cell surface proteoglycan, syndecan. Boutin, E.L., Sanderson, R.D., Bernfield, M., Cunha, G.R. Dev. Biol. (1991) [Pubmed]
  28. Syndecan-4 expression is associated with follicular atresia in mouse ovary. Ishiguro, K., Kojima, T., Taguchi, O., Saito, H., Muramatsu, T., Kadomatsu, K. Histochem. Cell Biol. (1999) [Pubmed]
  29. Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family. Spring, J., Goldberger, O.A., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Bernfield, M. Genomics (1994) [Pubmed]
  30. Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo. Sutherland, A.E., Sanderson, R.D., Mayes, M., Seibert, M., Calarco, P.G., Bernfield, M., Damsky, C.H. Development (1991) [Pubmed]
  31. Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature. Götte, M., Joussen, A.M., Klein, C., Andre, P., Wagner, D.D., Hinkes, M.T., Kirchhof, B., Adamis, A.P., Bernfield, M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  32. Molecular cloning of syndecan, an integral membrane proteoglycan. Saunders, S., Jalkanen, M., O'Farrell, S., Bernfield, M. J. Cell Biol. (1989) [Pubmed]
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