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Gene Review

Izumo1  -  izumo sperm-egg fusion 1

Rattus norvegicus

Synonyms: Izumo sperm-egg fusion protein 1, OBF, Oocyte binding/fusion factor, Sperm-specific protein izumo
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Disease relevance of LOC499152

  • A possible analogy with overload heart hypertrophy in vivo, where a reactivation of an early gene program including re-expression of ANF in ventricular myocytes has been described (Izumo et al., 1987; Chien et al., 1991), is proposed [1].
  • A phosphorothioate-linked 15-mer antisense ODN complementary to the initiation codon region of rat PDGF A-chain mRNA and a control sense ODN were infused subcutaneously into SHR-SP/Izumo at a dose of 90 ng/g body weight/day for 28 days using an implanted ALZET pump [2].

High impact information on LOC499152

  • BACKGROUND AND PURPOSE: To analyze the effects of substrain and gender differences in spontaneously hypertensive rats (SHR) and distal middle cerebral artery (MCA) branching patterns on infarct size, we compared infarct volumes produced by photothrombotic distal MCA occlusion using SHR/Kyushu and SHR/Izumo (Izm) [3].
  • DESIGN AND METHODS : VSMCs were obtained by an explant method from aortas of 4-week-old male SHR/Izumo and Wistar-Kyoto (WKY)/Izumo rats [4].
  • DESIGN: Cultured VSMC were prepared by an explant method from thoracic aortas in 8-week-old male Wistar-Kyoto (WKY)/Izumo rats and SHR/Izumo [5].
  • Two kidney 1 clip hypertensive rats (2K1C), 5/6 reduced renal mass hypertensive rats (5/6 RRM), deoxycorticosterone acetate-salt hypertensive rats (DOCA-salt), spontaneously hypertensive rats/Izumo (SHR/Iz), Dahl salt sensitive hypertensive rats/John Rapp (Dahl/Jr), Dahl/Iwai (Dahl/Iw), and respective controls were employed in this study [6].
  • 3. Four genetic markers at the SA locus, an StuI restriction fragment length polymorphism and three microsatellite markers, were not polymorphic among Izumo strains of SHR, SHRSP and WKY rats [7].

Analytical, diagnostic and therapeutic context of LOC499152

  • We examined DNA fingerprints of the spontaneously hypertensive rat from Shimane Institute of Health Science, Izumo, Japan, including seven substrains that were separated in the early stages of the establishment of the stroke-prone spontaneously hypertensive rat, and compared their fingerprints with those of rats from other sources [8].
  • 1. In situ hybridization done using a 35S-cRNA probe was carried out to obtain information on the expressions of the SA gene in brains and kidneys of the spontaneously hypertensive rat (SHR) strain obtained from the Izumo colony (/Izm) and from Charles River Laboratories (/Crj) [9].
  • Male 5/6-nephrectomized SHR/Izumo rats were randomly assigned to receive vehicle (control group), TMP (TMP group; 10 mg x kg(-1) x day(-1)), AZN (AZN group; 3 mg x kg(-1) x day(-1)), or both (TMP+AZN group) orally for 12 weeks [10].


  1. New occurrence of atrial natriuretic factor and storage in secretorially active granules in adult rat ventricular cardiomyocytes in long-term culture. Eppenberger-Eberhardt, M., Messerli, M., Eppenberger, H.M., Reinecke, M. J. Mol. Cell. Cardiol. (1993) [Pubmed]
  2. Effects of PDGF A-chain antisense oligodeoxynucleotides on growth of cardiovascular organs in stroke-prone spontaneously hypertensive rats. Kishioka, H., Fukuda, N., Wen-Yang, H., Nakayama, M., Watanabe, Y., Kanmatsuse, K. Am. J. Hypertens. (2001) [Pubmed]
  3. Photothrombotic middle cerebral artery occlusion in spontaneously hypertensive rats: influence of substrain, gender, and distal middle cerebral artery patterns on infarct size. Cai, H., Yao, H., Ibayashi, S., Uchimura, H., Fujishima, M. Stroke (1998) [Pubmed]
  4. Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats. Hu, W.Y., Fukuda, N., Kanmatsuse, K. J. Hypertens. (2002) [Pubmed]
  5. Low dose of eicosapentaenoic acid inhibits the exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats through suppression of transforming growth factor-beta. Nakayama, M., Fukuda, N., Watanabe, Y., Soma, M., Hu, W.Y., Kishioka, H., Satoh, C., Kubo, A., Kanmatsuse, K. J. Hypertens. (1999) [Pubmed]
  6. Comparative hypertensionology-renal dopaminergic activity in experimental hypertensive rats. Iimura, O., Ura, N., Nakagawa, M. Clin. Exp. Hypertens. (1997) [Pubmed]
  7. Re-evaluation of the SA gene in spontaneously hypertensive and Wistar-Kyoto rats. Ishinaga, Y., Nabika, T., Shimada, T., Hiraoka, J., Nara, Y., Yamori, Y. Clin. Exp. Pharmacol. Physiol. (1997) [Pubmed]
  8. Genetic heterogeneity of the spontaneously hypertensive rat. Nabika, T., Nara, Y., Ikeda, K., Endo, J., Yamori, Y. Hypertension (1991) [Pubmed]
  9. Strain differences in SA gene expression in brain and kidney of normotensive and hypertensive rats. Mishima, A., Shigematsu, K., Harada, N., Himeno, A., Taguchi, T., Ishinaga, Y., Nabika, T. Cell. Mol. Neurobiol. (2000) [Pubmed]
  10. Combination therapy with an angiotensin-converting enzyme (ACE) inhibitor and a calcium antagonist: beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal ablation. Kanazawa, M., Kohzuki, M., Yoshida, K., Kurosawa, H., Minami, N., Saito, T., Yasujima, M., Abe, K. Hypertens. Res. (2002) [Pubmed]
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