Disease relevance of IZUMO1

• Study of aneurysmal subarachnoid hemorrhage in Izumo City, Japan [1].
• Ruptured aneurysms were confirmed in 77 cases (93%) in Izumo City and 466 cases (85%) in Shimane Prefecture [2].
• Primary intracerebral hemorrhage in Izumo City, Japan: incidence rates and outcome in relation to the site of hemorrhage [3].
• SETTING: Shimane Medical University Hospital, Izumo, Japan. PATIENTS: Fifty-one consecutive patients with clinically suspected pelvic endometriosis [4].
• METHODS: The study population consisted of 350 patients who presented with primary ICH for the first time and were treated between 1991 and 1998 in Izumo City, Japan. Among the entire patient population, the onset of hemorrhage was rarely observed during the night and a peak was observed in the late afternoon [5].

High impact information on IZUMO1

• CONCLUSIONS: Among patients in Izumo, hypertension was the most notable risk factor for aneurysmal SAH, regardlessof age and sex, followed by cigarette smoking in younger men and hypercholesterolemia in older women [6].
• Diurnal and seasonal variations in the onset of primary intracerebral hemorrhage in individuals living in Izumo City, Japan [5].
• SETTING: Department of Obstetrics and Gynecology, Shimane Medical University Hospital, Izumo, Japan. PATIENT(S): Two hundred forty-five Japanese women with endocrine disorders and/or gynecologic disease and 153 healthy, nonpregnant, fertile Japanese women [7].
• SETTING: Shimane Medical University Hospital, Izumo, Japan. PATIENTS: Eleven consecutive patients with at least one endometrioma > 10 mm in maximal diameter that was diagnosed by laparoscopy and treated with 900 micrograms/d buserelin acetate for 6 months [8].
• SETTING: Infertility and Endocrine Clinic, Department of Obstetrics Gynecology, Shimane Medical University Hospital, Izumo, Japan. PATIENTS: Forty-seven infertile patients with PCOS and 30 healthy volunteers [9].

Biological context of IZUMO1

• Samples were analyzed at CARDIAC center in Izumo, Japan. Mean systolic blood pressure (SBP) was not much different in the two populations, but mean diastolic blood pressure (DBP) and body mass index (BMI) were significantly lower in Vilcabamba (p less than 0.001) [10].

Anatomical context of IZUMO1

• Recent study by Malek and Izumo suggested the importance of microtubules in shear stress-induced morphological change and actin stress fiber formation [11].

Associations of IZUMO1 with chemical compounds

• The nutritional information was coded and the data stored by the nutritional analyses facility at Albert Einstein College of Medicine. The chemical determinations were done in the laboratories of the Department of Pathology, Izumo, Japan. The correlation between total protein and 3-methylhistidine was r = 0.42 (n = 96) [12].

Analytical, diagnostic and therapeutic context of IZUMO1

• METHODS: A case-control study of 247 patients (108 men and 139 women with ages ranging from 28-96 years) with aneurysmal SAH was conducted in Izumo between 1980 and 1998 [6].
• CONCLUSIONS: The overall survival rates for patients with ICH or SAH in Izumo were more favorable than those in previously published epidemiological studies [13].

References