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Gene Review

IZUMO1  -  izumo sperm-egg fusion 1

Homo sapiens

Synonyms: IZUMO, Izumo sperm-egg fusion protein 1, MGC34799, OBF, Oocyte binding/fusion factor, ...
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Disease relevance of IZUMO1

  • Study of aneurysmal subarachnoid hemorrhage in Izumo City, Japan [1].
  • Ruptured aneurysms were confirmed in 77 cases (93%) in Izumo City and 466 cases (85%) in Shimane Prefecture [2].
  • Primary intracerebral hemorrhage in Izumo City, Japan: incidence rates and outcome in relation to the site of hemorrhage [3].
  • SETTING: Shimane Medical University Hospital, Izumo, Japan. PATIENTS: Fifty-one consecutive patients with clinically suspected pelvic endometriosis [4].
  • METHODS: The study population consisted of 350 patients who presented with primary ICH for the first time and were treated between 1991 and 1998 in Izumo City, Japan. Among the entire patient population, the onset of hemorrhage was rarely observed during the night and a peak was observed in the late afternoon [5].

High impact information on IZUMO1


Biological context of IZUMO1

  • Samples were analyzed at CARDIAC center in Izumo, Japan. Mean systolic blood pressure (SBP) was not much different in the two populations, but mean diastolic blood pressure (DBP) and body mass index (BMI) were significantly lower in Vilcabamba (p less than 0.001) [10].

Anatomical context of IZUMO1


Associations of IZUMO1 with chemical compounds

  • The nutritional information was coded and the data stored by the nutritional analyses facility at Albert Einstein College of Medicine. The chemical determinations were done in the laboratories of the Department of Pathology, Izumo, Japan. The correlation between total protein and 3-methylhistidine was r = 0.42 (n = 96) [12].

Analytical, diagnostic and therapeutic context of IZUMO1


  1. Study of aneurysmal subarachnoid hemorrhage in Izumo City, Japan. Inagawa, T., Tokuda, Y., Ohbayashi, N., Takaya, M., Moritake, K. Stroke (1995) [Pubmed]
  2. Aneurysmal subarachnoid hemorrhage in Izumo City and Shimane Prefecture of Japan. Incidence. Inagawa, T., Ishikawa, S., Aoki, H., Takahashi, M., Yoshimoto, H. Stroke (1988) [Pubmed]
  3. Primary intracerebral hemorrhage in Izumo City, Japan: incidence rates and outcome in relation to the site of hemorrhage. Inagawa, T., Ohbayashi, N., Takechi, A., Shibukawa, M., Yahara, K. Neurosurgery (2003) [Pubmed]
  4. Diagnosis of pelvic endometriosis by magnetic resonance imaging using "fat-saturation" technique. Takahashi, K., Okada, S., Ozaki, T., Kitao, M., Sugimura, K. Fertil. Steril. (1994) [Pubmed]
  5. Diurnal and seasonal variations in the onset of primary intracerebral hemorrhage in individuals living in Izumo City, Japan. Inagawa, T. J. Neurosurg. (2003) [Pubmed]
  6. Risk factors for aneurysmal subarachnoid hemorrhage in patients in Izumo City, Japan. Inagawa, T. J. Neurosurg. (2005) [Pubmed]
  7. Increased prevalence of luteinizing hormone beta-subunit variant in patients with premature ovarian failure. Takahashi, K., Ozaki, T., Okada, M., Kurioka, H., Kanasaki, H., Miyazaki, K. Fertil. Steril. (1999) [Pubmed]
  8. Magnetic resonance imaging and serum CA-125 in evaluating patients with endometriomas prior to medical therapy. Takahashi, K., Okada, S., Okada, M., Kitao, M., Kaji, Y., Sugimura, K. Fertil. Steril. (1996) [Pubmed]
  9. Transvaginal ultrasonic assessment of the response to clomiphene citrate in polycystic ovarian syndrome. Takahashi, K., Uchida, A., Yamasaki, H., Ozaki, T., Kitao, M. Fertil. Steril. (1994) [Pubmed]
  10. Cardiovascular risk factors in two Ecuadorian urban and rural populations. The Ecuadorian-Japan Cooperative CARDIAC Study Group. Del Pozo, G., Davalos, P., Yamori, Y. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  11. Fluid shear stress-mediated signal transduction: how do endothelial cells transduce mechanical force into biological responses? Ishida, T., Takahashi, M., Corson, M.A., Berk, B.C. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  12. Estimation of protein intake: comparison of dietary assessment and urinary excretion. Wassertheil-Smoller, S., Langford, H.G., Yamori, Y., Blaufox, M.D., Oberman, A., Davis, B., Nara, Y., Wylie-Rosett, J., Zimbaldi, N. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  13. Primary intracerebral and aneurysmal subarachnoid hemorrhage in Izumo City, Japan. Part II: management and surgical outcome. Inagawa, T., Shibukawa, M., Inokuchi, F., Tokuda, Y., Okada, Y., Okada, K. J. Neurosurg. (2000) [Pubmed]
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