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Gene Review

OTX1  -  orthodenticle homeobox 1

Homo sapiens

Synonyms: Homeobox protein OTX1, Orthodenticle homolog 1
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Disease relevance of OTX1


High impact information on OTX1


Anatomical context of OTX1


Other interactions of OTX1

  • OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm [5].

Analytical, diagnostic and therapeutic context of OTX1


  1. OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas. de Haas, T., Oussoren, E., Grajkowska, W., Perek-Polnik, M., Popovic, M., Zadravec-Zaletel, L., Perera, M., Corte, G., Wirths, O., van Sluis, P., Pietsch, T., Troost, D., Baas, F., Versteeg, R., Kool, M. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  2. Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation. Acampora, D., Avantaggiato, V., Tuorto, F., Briata, P., Corte, G., Simeone, A. Development (1998) [Pubmed]
  3. Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1. Francks, C., Fisher, S.E., Olson, R.K., Pennington, B.F., Smith, S.D., DeFries, J.C., Monaco, A.P. Psychiatr. Genet. (2002) [Pubmed]
  4. Development and evolution of the vestibular sensory apparatus of the mammalian ear. Beisel, K.W., Wang-Lundberg, Y., Maklad, A., Fritzsch, B. Journal of vestibular research : equilibrium & orientation. (2005) [Pubmed]
  5. OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Acampora, D., Annino, A., Puelles, E., Alfano, I., Tuorto, F., Simeone, A. Gene Expr. Patterns (2003) [Pubmed]
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