Gene Review:
Otx1 - orthodenticle homolog 1
Mus musculus
Synonyms:
A730044F23Rik, Homeobox protein OTX1, Orthodenticle homolog 1, Otx-1, jv
- Epilepsy and brain abnormalities in mice lacking the Otx1 gene. Acampora, D., Mazan, S., Avantaggiato, V., Barone, P., Tuorto, F., Lallemand, Y., Brûlet, P., Simeone, A. Nat. Genet. (1996)
- Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation. Acampora, D., Avantaggiato, V., Tuorto, F., Briata, P., Corte, G., Simeone, A. Development (1998)
- Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH. Acampora, D., Mazan, S., Tuorto, F., Avantaggiato, V., Tremblay, J.J., Lazzaro, D., di Carlo, A., Mariano, A., Macchia, P.E., Corte, G., Macchia, V., Drouin, J., Brûlet, P., Simeone, A. Development (1998)
- Nested expression domains of four homeobox genes in developing rostral brain. Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A., Boncinelli, E. Nature (1992)
- Mouse Otx2 functions in the formation and patterning of rostral head. Matsuo, I., Kuratani, S., Kimura, C., Takeda, N., Aizawa, S. Genes Dev. (1995)
- Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Xu, B., Zang, K., Ruff, N.L., Zhang, Y.A., McConnell, S.K., Stryker, M.P., Reichardt, L.F. Neuron (2000)
- Otx genes are required for tissue specification in the developing eye. Martinez-Morales, J.R., Signore, M., Acampora, D., Simeone, A., Bovolenta, P. Development (2001)
- Differential expression of two different homeobox gene families during mouse tegument morphogenesis. Kanzler, B., Viallet, J.P., Le Mouellic, H., Boncinelli, E., Duboule, D., Dhouailly, D. Int. J. Dev. Biol. (1994)
- The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis. Acampora, D., Simeone, A. Trends Neurosci. (1999)
- A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M.R., Nigro, V., Boncinelli, E. EMBO J. (1993)
- Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development. Thomas, T., Voss, A.K., Chowdhury, K., Gruss, P. Development (2000)
- Genetic control of brain morphogenesis through Otx gene dosage requirement. Acampora, D., Avantaggiato, V., Tuorto, F., Simeone, A. Development (1997)
- Emx1 and Emx2 show different patterns of expression during proliferation and differentiation of the developing cerebral cortex in the mouse. Gulisano, M., Broccoli, V., Pardini, C., Boncinelli, E. Eur. J. Neurosci. (1996)
- OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Acampora, D., Annino, A., Puelles, E., Alfano, I., Tuorto, F., Simeone, A. Gene Expr. Patterns (2003)
- Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets. Weimann, J.M., Zhang, Y.A., Levin, M.E., Devine, W.P., Brûlet, P., McConnell, S.K. Neuron (1999)
- Synaptic properties of neocortical neurons in epileptic mice lacking the Otx1 gene. Avanzini, G., Spreafico, R., Cipelletti, B., Sancini, G., Frassoni, C., Franceschetti, S., Lavazza, T., Panzica, F., Acampora, D., Simeone, A. Epilepsia (2000)
- Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis. Levantini, E., Giorgetti, A., Cerisoli, F., Traggiai, E., Guidi, A., Martin, R., Acampora, D., Aplan, P.D., Keller, G., Simeone, A., Iscove, N.N., Hoang, T., Magli, M.C. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression. Tarabykin, V., Stoykova, A., Usman, N., Gruss, P. Development (2001)
- Longitudinal organization of the anterior neural plate and neural tube. Shimamura, K., Hartigan, D.J., Martinez, S., Puelles, L., Rubenstein, J.L. Development (1995)
- Morphological organization of somatosensory cortex in Otx1(-/-) mice. Cipelletti, B., Avanzini, G., Vitellaro-Zuccarello, L., Franceschetti, S., Sancini, G., Lavazza, T., Acampora, D., Simeone, A., Spreafico, R., Frassoni, C. Neuroscience (2002)
- Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Morsli, H., Tuorto, F., Choo, D., Postiglione, M.P., Simeone, A., Wu, D.K. Development (1999)
- Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain. Suda, Y., Matsuo, I., Kuratani, S., Aizawa, S. Genes Cells (1996)