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Gene Review

Otx1  -  orthodenticle homeobox 1

Rattus norvegicus

Synonyms: Homeobox protein OTX1, Orthodenticle homolog 1
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High impact information on Otx1


Biological context of Otx1

  • Knockout Otx1 mice present a microcephalic phenotype mainly due to reduced deep neocortical layers and spontaneous recurrent seizures [4].
  • The pyramidal neurons recorded in Otx1-/- mice responded to near-threshold electrical stimulation of the underlying white matter, with aberrant polysynaptic excitatory potentials often leading to late action potential generation [4].

Associations of Otx1 with chemical compounds

  • Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice [4].

Analytical, diagnostic and therapeutic context of Otx1

  • To explore the molecular underpinnings of pattern formation in layered regions of the CNS, we have characterized the patterns of expression of two homeodomain genes, Otx1 and Otx2, by in situ hybridization during embryonic and postnatal development in the rat [1].


  1. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. Frantz, G.D., Weimann, J.M., Levin, M.E., McConnell, S.K. J. Neurosci. (1994) [Pubmed]
  2. Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. Zhang, Y., Miki, T., Iwanaga, T., Koseki, Y., Okuno, M., Sunaga, Y., Ozaki, N., Yano, H., Koseki, H., Seino, S. J. Biol. Chem. (2002) [Pubmed]
  3. Regulated nuclear trafficking of the homeodomain protein otx1 in cortical neurons. Zhang, Y.A., Okada, A., Lew, C.H., McConnell, S.K. Mol. Cell. Neurosci. (2002) [Pubmed]
  4. Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice. Sancini, G., Franceschetti, S., Lavazza, T., Panzica, F., Cipelletti, B., Frassoni, C., Spreafico, R., Acampora, D., Avanzini, G. Eur. J. Neurosci. (2001) [Pubmed]
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