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Gene Review

PMP2  -  peripheral myelin protein 2

Bos taurus

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Disease relevance of PMP2


High impact information on PMP2


Biological context of PMP2

  • Polyclonal rabbit antiserum raised against mammary derived growth inhibitor cross-reacts with bovine heart fatty acid binding protein and bovine peripheral myelin P2 protein [7].

Anatomical context of PMP2


Analytical, diagnostic and therapeutic context of PMP2


  1. Peripheral nervous system (PNS) expression of mRNAs encoding myelin proteins and Fc gamma RIII during experimental allergic neuritis. Conti, G., Vedeler, C., Bannerman, P., Rostami, A., Pleasure, D. J. Neuroimmunol. (1992) [Pubmed]
  2. Alteration of the binding specificity of cellular retinol-binding protein II by site-directed mutagenesis. Cheng, L., Qian, S.J., Rothschild, C., d'Avignon, A., Lefkowith, J.B., Gordon, J.I., Li, E. J. Biol. Chem. (1991) [Pubmed]
  3. Identification of a polypeptide growth inhibitor from bovine mammary gland. Sequence homology to fatty acid- and retinoid-binding proteins. Böhmer, F.D., Kraft, R., Otto, A., Wernstedt, C., Hellman, U., Kurtz, A., Müller, T., Rohde, K., Etzold, G., Lehmann, W. J. Biol. Chem. (1987) [Pubmed]
  4. Bovine peripheral nervous system myelin P2 protein: chemical and immunological characterization of the cyanogen bromide peptides. Weise, M.J., Hsieh, D., Hoffman, P.M., Powers, J.M., Brostoff, S.W. J. Neurochem. (1980) [Pubmed]
  5. Induction of severe experimental autoimmune neuritis with a synthetic peptide corresponding to the 53-78 amino acid sequence of the myelin P2 protein. Rostami, A., Gregorian, S.K., Brown, M.J., Pleasure, D.E. J. Neuroimmunol. (1990) [Pubmed]
  6. Structure of myelin P2 protein from equine spinal cord. Hunter, D.J., Macmaster, R., Roszak, A.W., Riboldi-Tunnicliffe, A., Griffiths, I.R., Freer, A.A. Acta Crystallogr. D Biol. Crystallogr. (2005) [Pubmed]
  7. Antibodies against mammary derived growth inhibitor (MDGI) react with a fibroblast growth inhibitor and with heart fatty acid binding protein. Böhmer, F.D., Sun, Q., Pepperle, M., Müller, T., Eriksson, U., Wang, J.L., Grosse, R. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  8. Peptide 53-78 of myelin P2 protein is a T cell epitope for the induction of experimental autoimmune neuritis. Rostami, A., Gregorian, S.K. Cell. Immunol. (1991) [Pubmed]
  9. The secondary structure of myelin P2 protein derived by secondary structure prediction methods, circular dichroism, and 400-MHz 1H-NMR spectroscopy: implications for tertiary structure. Shin, H.C., McFarlane, E.F. Biochim. Biophys. Acta (1987) [Pubmed]
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