The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pmp2  -  peripheral myelin protein 2

Mus musculus

Synonyms: Myelin P2 protein, P2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pmp2

  • To investigate the regulation of expression of this myelin protein, a mouse genomic library was screened with a rabbit P2 cDNA (pSN2.2-2), and a single positive phage clone containing a 20-kb insert was obtained [1].
  • In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance in experimental allergic neuritis [2].

High impact information on Pmp2

  • Kirschner and Ganser, however, using SDS-polyacrylamide gel electrophoresis, reported that P2, as well as P1, is absent from shiverer sciatic nerve [3].
  • Transcription was assayed by hybridization of newly synthesized RNA to cDNA clones coding for glycerophosphate dehydrogenase (GPD), the induced protein of 13K which is shown here to be related to myelin protein P-2, the induced protein of 28K, actin, and two RNAs that are not developmentally regulated [4].
  • We have isolated the mouse gene encoding adipocyte P2, aP2, the differentiation-dependent adipocyte protein homologous to myelin P2 [5].
  • Computer-assisted analyses showed that the 422 protein shares 69% and 64% homology with myelin P2 proteins from rabbit and bovine peripheral nerves, respectively, as well as 23% and 30% homology with fatty-acid binding proteins from rat liver and intestine, respectively [6].
  • Crystalline ALBP has a conformation which is essentially identical to that of intestinal fatty acid binding protein and myelin P2 protein [7].

Biological context of Pmp2

  • When the gene structure of fatty acid binding protein (FABP) genes were compared, the P2 gene had the same overall structure as others in the FABP family, suggesting a common ancestral gene for members of this family [1].
  • Primer extension analysis revealed two transcription start sites at +1 and +47, consistent with the presence of two P2 mRNAs, with the larger transcript appearing more abundant [1].
  • To investigate the DNA elements that control the expression of P2, sequences 5' to the coding region were cloned upstream of the cat reporter gene [8].
  • Fluorescence in-situ hybridization identified the murine KLBP gene as the fourth FABP gene on chromosome 3, along with myelin P2, ALBP, and intestinal FABP [9].
  • This protein has 70% and 20-30% amino acid sequence homology to myelin P2 and the fatty acid binding proteins of liver and intestine, respectively [10].

Anatomical context of Pmp2


Associations of Pmp2 with chemical compounds


  1. Structure of the mouse myelin P2 protein gene. Narayanan, V., Kaestner, K.H., Tennekoon, G.I. J. Neurochem. (1991) [Pubmed]
  2. In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance in experimental allergic neuritis. Strigård, K., Larsson, P., Holmdahl, R., Klareskog, L., Olsson, T. J. Neuroimmunol. (1989) [Pubmed]
  3. Shiverer peripheral myelin contains P2. Winter, J. Nature (1982) [Pubmed]
  4. Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control. Cook, K.S., Hunt, C.R., Spiegelman, B.M. J. Cell Biol. (1985) [Pubmed]
  5. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Hunt, C.R., Ro, J.H., Dobson, D.E., Min, H.Y., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Bernlohr, D.A., Angus, C.W., Lane, M.D., Bolanowski, M.A., Kelly, T.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  7. Crystal structure of recombinant murine adipocyte lipid-binding protein. Xu, Z., Bernlohr, D.A., Banaszak, L.J. Biochemistry (1992) [Pubmed]
  8. Characterization of the cis-acting elements of the mouse myelin P2 promoter. Bharucha, V.A., Peden, K.W., Subach, B.R., Narayanan, V., Tennekoon, G.I. J. Neurosci. Res. (1993) [Pubmed]
  9. Cloning and chromosomal location of the murine keratinocyte lipid-binding protein gene. Hertzel, A.V., Bernlohr, D.A. Gene (1998) [Pubmed]
  10. Tissue specific expression of p422 protein, a putative lipid carrier, in mouse adipocytes. Bernlohr, D.A., Doering, T.L., Kelly, T.J., Lane, M.D. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  11. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. Smith, P.J., Wise, L.S., Berkowitz, R., Wan, C., Rubin, C.S. J. Biol. Chem. (1988) [Pubmed]
WikiGenes - Universities