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Gene Review

PMP2  -  peripheral myelin protein 2

Homo sapiens

Synonyms: FABP8, M-FABP, MP2, Myelin P2 protein, P2, ...
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Disease relevance of PMP2


High impact information on PMP2

  • The allergen, formally termed rAsp f 8, shares >62% sequence identity and >84% sequence homology to corresponding eukaryotic P2 proteins, including human P2 protein [2].
  • To investigate the mechanisms of action of PMPs leading to membrane damage, we used flow cytometry to compare the effects of two distinct PMPs (thrombin-induced PMP-1 [tPMP-1] or PMP-2) with human neutrophil defensin-1 (hNP-1) on transmembrane potential (Deltapsi), membrane permeabilization, and killing of S. aureus [5].
  • Collectively, these data indicate that membrane dysfunction and cell death due to tPMP-1, PMP-2, or hNP-1 likely involve different mechanisms [5].
  • Growth in menadione reconstituted Deltapsi of JB-1 to a level equivalent to 6850, and was associated with greater depolarization due to PMP-2, but not tPMP-1 [5].
  • P2 peptide could also be isolated from the EBV-transformed B cells that were transfected by HBcAg-expressing vector [4].

Chemical compound and disease context of PMP2

  • Two myelin proteins, P2 basic protein and P0 glycoprotein, can induce experimental autoimmune neuritis (EAN), a model of human inflammatory neuropathy [6].
  • Using polyacrylamide gel electrophoresis, the viral proteins were identified as derived from the P1 (5' terminal), P2 (middle), or P3 (3' terminal) region of the poliovirus translation unit [7].
  • When injected i.p. into histocompatible Lewis or F1 (Lewis X P2) recipients, the BP-1 line induced both clinical signs of experimental autoimmune encephalomyelitis (EAE) and delayed type hypersensitivity (DTH) reactions in ears challenged intradermally with GP-BP but not PPD [8].
  • In the case of BH10-LD3, these four mutations were MA1, CA1, MP2, and MNC, and they involved changes of amino acid Val-35 to Ile within the matrix protein (MA), Ile-91 to Thr within the capsid (CA), Thr-12 to Ile within p2, and Thr-24 to Ile within the nucleocapsid (NC) [9].
  • Compared to the lower resolution NMR structure for the homologous protein P2 from the Pseudomonas sp. CF600 phenol hydroxylase system (RMSD = 2.48 A for backbone atoms) (Qian, H., Edlund, U., Powlowski, J., Shingler, V., and Sethson, I. (1997) Biochemistry, 36, 495-504), that of MMOB reveals a considerably more compact protein [10].

Biological context of PMP2


Anatomical context of PMP2


Associations of PMP2 with chemical compounds

  • The complete amino acid sequence of P2 protein from human peripheral nerve myelin was determined from nine staphylococcal protease peptides and four cyanogen bromide peptides [13].
  • Several generalized dissociation pathways were proposed and were evaluated theoretically with truncated leucine-containing models using ab initio calculations at B3-PMP2/6-311 ++ G(3df,2p)//B3LYP/6-31 ++ G(d,p) level [19].
  • Product analysis, isotope labeling ((2)H and (18)O), and potential energy surface mapping by ab initio calculations at the G2(MP2) and B3-PMP2 levels of theory and in combination with Rice-Ramsperger-Kassel-Marcus (RRKM) kinetic calculations are used to assign the major and some minor pathways for 1 dissociations [20].
  • In the present study the ionization energy thresholds (IET's) of uracil and thymine have been calculated (with the B3LYP, PMP2, and P3 levels of theory using the standard 6-31++G(d,p) basis set) with one to three water molecules placed in the first hydration shell [21].
  • The cysteine and selenocysteine oxidation by H2O2 in vacuo and in aqueous solution was studied using the integrated molecular orbital + molecular orbital (IMOMO) method combining the quadratic configuration method QCISD(T) and the spin projection of second-order perturbation theory PMP2 [22].

Other interactions of PMP2


Analytical, diagnostic and therapeutic context of PMP2

  • Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin [25].
  • PCR was performed with primer pairs V1-PMP2, V1-EB450, and V1-SI500, and the nature of the PCR products was confirmed by Southern blot hybridization [26].
  • Rabbit antibody prepared against P2 from one strain was cross-reactive with P2 isolated from the other two heterologous strains by Western blot [3].
  • Here we demonstrate that i.v. administration of as little as 100 microg of recombinant P2 protein twice daily completely prevents experimental autoimmune neuritis induced by adoptive transfer of neuritogenic P2-specific T cells or by immunization with the neuritogenic P2-peptide-spanning amino acids 53-78 [27].
  • P0, P1, and P2 were isolated as a macromolecular complex by preparative isoelectric focusing and anion-exchange chromatography in the presence of 6 M urea [28].


  1. The complete amino acid sequence of the rabbit P2 protein. Ishaque, A., Hofmann, T., Eylar, E.H. J. Biol. Chem. (1982) [Pubmed]
  2. Humoral and cell-mediated autoimmune reactions to human acidic ribosomal P2 protein in individuals sensitized to Aspergillus fumigatus P2 protein. Mayer, C., Appenzeller, U., Seelbach, H., Achatz, G., Oberkofler, H., Breitenbach, M., Blaser, K., Crameri, R. J. Exp. Med. (1999) [Pubmed]
  3. Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates. Munson, R.S., Shenep, J.L., Barenkamp, S.J., Granoff, D.M. J. Clin. Invest. (1983) [Pubmed]
  4. Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes. Tsai, S.L., Chen, M.H., Yeh, C.T., Chu, C.M., Lin, A.N., Chiou, F.H., Chang, T.H., Liaw, Y.F. J. Clin. Invest. (1996) [Pubmed]
  5. Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of action. Yeaman, M.R., Bayer, A.S., Koo, S.P., Foss, W., Sullam, P.M. J. Clin. Invest. (1998) [Pubmed]
  6. Induction of experimental autoimmune neuritis with peripheral myelin protein-22. Gabriel, C.M., Hughes, R.A., Moore, S.E., Smith, K.J., Walsh, F.S. Brain (1998) [Pubmed]
  7. Lycorine: a eukaryotic termination inhibitor? Vrijsen, R., Vanden Berghe, D.A., Vlietinck, A.J., Boeyé, A. J. Biol. Chem. (1986) [Pubmed]
  8. A myelin basic protein-specific T lymphocyte line that mediates experimental autoimmune encephalomyelitis. Vandenbark, A.A., Gill, T., Offner, H. J. Immunol. (1985) [Pubmed]
  9. Mutations within four distinct gag proteins are required to restore replication of human immunodeficiency virus type 1 after deletion mutagenesis within the dimerization initiation site. Liang, C., Rong, L., Quan, Y., Laughrea, M., Kleiman, L., Wainberg, M.A. J. Virol. (1999) [Pubmed]
  10. Solution structure of component B from methane monooxygenase derived through heteronuclear NMR and molecular modeling. Chang, S.L., Wallar, B.J., Lipscomb, J.D., Mayo, K.H. Biochemistry (1999) [Pubmed]
  11. Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2). Hayasaka, K., Himoro, M., Takada, G., Takahashi, E., Minoshima, S., Shimizu, N. Genomics (1993) [Pubmed]
  12. Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2). Besançon, R., Latour, P., Lara, K., Laetitia, B., Mularoni, A., Chamba, G., Vandenberghe, A. Hum. Mutat. (2001) [Pubmed]
  13. The complete amino acid sequence of human P2 protein. Suzuki, M., Kitamura, K., Sakamoto, Y., Uyemura, K. J. Neurochem. (1982) [Pubmed]
  14. Speciation of human microsporidia by polymerase chain reaction single-strand conformation polymorphism. Fedorko, D.P., Nelson, N.A., Didier, E.S., Bertucci, D., Delgado, R.M., Hruszkewycz, A.M. Am. J. Trop. Med. Hyg. (2001) [Pubmed]
  15. Partial structure and mapping of the human myelin P2 protein gene. Narayanan, V., Ripepi, B., Jabs, E.W., Hawkins, A., Griffin, C., Tennekoon, G. J. Neurochem. (1994) [Pubmed]
  16. Alterations in the Arf6-regulated plasma membrane endosomal recycling pathway in cells overexpressing the tetraspan protein Gas3/PMP22. Chies, R., Nobbio, L., Edomi, P., Schenone, A., Schneider, C., Brancolini, C. J. Cell. Sci. (2003) [Pubmed]
  17. The three-dimensional structure of P2 myelin protein. Jones, T.A., Bergfors, T., Sedzik, J., Unge, T. EMBO J. (1988) [Pubmed]
  18. Characterization of a cloned cDNA encoding rabbit myelin P2 protein. Narayanan, V., Barbosa, E., Reed, R., Tennekoon, G. J. Biol. Chem. (1988) [Pubmed]
  19. Experimental and theoretical investigations of the loss of amino Acid side chains in electron capture dissociation of model peptides. Fung, Y.M., Chan, T.W. J. Am. Soc. Mass Spectrom. (2005) [Pubmed]
  20. Modeling deoxyribose radicals by neutralization-reionization mass spectrometry. Part 1. Preparation, dissociations, and energetics of 2-hydroxyoxolan-2-yl radical, neutral isomers, and cations. Vivekananda, S., Sadílek, M., Chen, X., Turecek, F. J. Am. Soc. Mass Spectrom. (2004) [Pubmed]
  21. The influence of microhydration on the ionization energy thresholds of uracil and thymine. Close, D.M., Crespo-Hernández, C.E., Gorb, L., Leszczynski, J. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  22. Selenocysteine versus Cysteine Reactivity: A Theoretical Study of Their Oxidation by Hydrogen Peroxide. Cardey, B., Enescu, M. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory (2007) [Pubmed]
  23. The autoimmune features of acute transverse myelopathy. Abramsky, O., Teitelbaum, D. Ann. Neurol. (1977) [Pubmed]
  24. Physical and genetic mapping of the CMT4A locus and exclusion of PMP-2 as the defect in CMT4A. Othmane, K.B., Loeb, D., Hayworth-Hodgte, R., Hentati, F., Rao, N., Roses, A.D., Ben Hamida, M., Pericak-Vance, M.A., Vance, J.M. Genomics (1995) [Pubmed]
  25. Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin. Hayasaka, K., Nanao, K., Tahara, M., Sato, W., Takada, G., Miura, M., Uyemura, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  26. A powerful DNA extraction method and PCR for detection of microsporidia in clinical stool specimens. Müller, A., Stellermann, K., Hartmann, P., Schrappe, M., Fätkenheuer, G., Salzberger, B., Diehl, V., Franzen, C. Clin. Diagn. Lab. Immunol. (1999) [Pubmed]
  27. Antigen therapy eliminates T cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. Weishaupt, A., Gold, R., Gaupp, S., Giegerich, G., Hartung, H.P., Toyka, K.V. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  28. Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Elkon, K., Skelly, S., Parnassa, A., Moller, W., Danho, W., Weissbach, H., Brot, N. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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