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Gene Review

Magi2  -  membrane associated guanylate kinase, WW...

Mus musculus

Synonyms: AIP-1, Activin receptor-interacting protein 1, Acvri1, Acvrinp1, Acvrip1, ...
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High impact information on Magi2

  • Thus, MAGI-2 overexpression in F9 vin(-/-) cells restored PTEN protein levels [1].
  • These studies indicate that PTEN protein levels are dependent on the maintenance of beta-catenin-MAGI-2 interaction, in which vinculin plays a critical role [1].
  • MAGI-2 interaction with PTEN in the cell membrane is known to prevent PTEN protein degradation [1].
  • ARIP1-long had one guanylate kinase domain in the NH(2)-terminal region, followed by two WW domains and five PDZ domains (PDZ1-5) [2].
  • The COOH-terminal residues of ActRIIA (ESSL) agree with a PDZ-binding consensus motif, and ARIP1 recognized the consensus sequence [2].

Biological context of Magi2

  • By using yeast two-hybrid screening, we isolated a cDNA clone of ARIP1 from a mouse brain cDNA library [2].
  • These findings suggest that ARIP1 has a significant role in assembling activin signaling molecules at specific subcellular sites and in regulating signal transduction in neuronal cells [2].
  • We detected two forms of ARIP1, ARIP1-long and ARIP1-short, which may be produced by alternative splicing [2].

Anatomical context of Magi2


Regulatory relationships of Magi2

  • Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain [4].

Other interactions of Magi2

  • Expression of stargazin recruited MAGI-2 to cell membranes and cell-cell contact sites in transfected HEK-293T cells dependent on the presence of the stargazin -TTPV motif [4].
  • We used yeast two-hybrid screening to identify MAGI-2 (membrane associated guanylate kinase, WW and PDZ domain containing 2) as a novel candidate interactor with the cytoplasmic C termini of the TARPs [4].


  1. Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. Subauste, M.C., Nalbant, P., Adamson, E.D., Hahn, K.M. J. Biol. Chem. (2005) [Pubmed]
  2. Identification and characterization of a PDZ protein that interacts with activin type II receptors. Shoji, H., Tsuchida, K., Kishi, H., Yamakawa, N., Matsuzaki, T., Liu, Z., Nakamura, T., Sugino, H. J. Biol. Chem. (2000) [Pubmed]
  3. BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Kishigami, S., Yoshikawa, S., Castranio, T., Okazaki, K., Furuta, Y., Mishina, Y. Dev. Biol. (2004) [Pubmed]
  4. Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain. Deng, F., Price, M.G., Davis, C.F., Mori, M., Burgess, D.L. J. Neurosci. (2006) [Pubmed]
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