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Gene Review

Vcl  -  vinculin

Mus musculus

Synonyms: 9430097D22, AA571387, AI462105, AW545629, Metavinculin, ...
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Disease relevance of Vcl


High impact information on Vcl


Chemical compound and disease context of Vcl


Biological context of Vcl


Anatomical context of Vcl


Associations of Vcl with chemical compounds


Physical interactions of Vcl


Co-localisations of Vcl


Regulatory relationships of Vcl


Other interactions of Vcl


Analytical, diagnostic and therapeutic context of Vcl


  1. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Zemljic-Harpf, A.E., Ponrartana, S., Avalos, R.T., Jordan, M.C., Roos, K.P., Dalton, N.D., Phan, V.Q., Adamson, E.D., Ross, R.S. Am. J. Pathol. (2004) [Pubmed]
  2. Focal adhesion formation by F9 embryonal carcinoma cells after vinculin gene disruption. Volberg, T., Geiger, B., Kam, Z., Pankov, R., Simcha, I., Sabanay, H., Coll, J.L., Adamson, E., Ben-Ze'ev, A. J. Cell. Sci. (1995) [Pubmed]
  3. Trypanosoma cruzi infection disrupts vinculin costameres in cardiomyocytes. Melo, T.G., Almeida, D.S., de Meirelles, M.d.e. .N., Pereira, M.C. Eur. J. Cell Biol. (2004) [Pubmed]
  4. Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cells. Ottlinger, M.E., Lin, S. Exp. Cell Res. (1988) [Pubmed]
  5. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Nobes, C.D., Hall, A. Cell (1995) [Pubmed]
  6. Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Gilmore, A.P., Burridge, K. Nature (1996) [Pubmed]
  7. Cell contact- and shape-dependent regulation of vinculin synthesis in cultured fibroblasts. Ungar, F., Geiger, B., Ben-Ze'ev, A. Nature (1986) [Pubmed]
  8. PKC mediates 12(S)-HETE-induced cytoskeletal rearrangement in B16a melanoma cells. Timar, J., Tang, D., Bazaz, R., Haddad, M.M., Kimler, V.A., Taylor, J.D., Honn, K.V. Cell Motil. Cytoskeleton (1993) [Pubmed]
  9. Adriamycin-induced inhibition of melanoma cell invasion is correlated with decreases in tumor cell motility and increases in focal contact formation. Repesh, L.A., Drake, S.R., Warner, M.C., Downing, S.W., Jyring, R., Seftor, E.A., Hendrix, M.J., McCarthy, J.B. Clin. Exp. Metastasis (1993) [Pubmed]
  10. Vinculin knockout results in heart and brain defects during embryonic development. Xu, W., Baribault, H., Adamson, E.D. Development (1998) [Pubmed]
  11. Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. Subauste, M.C., Nalbant, P., Adamson, E.D., Hahn, K.M. J. Biol. Chem. (2005) [Pubmed]
  12. Integrin-mediated cell adhesion: the cytoskeletal connection. Critchley, D.R., Holt, M.R., Barry, S.T., Priddle, H., Hemmings, L., Norman, J. Biochem. Soc. Symp. (1999) [Pubmed]
  13. Role of interaction with vinculin in recruitment of vinexins to focal adhesions. Takahashi, H., Mitsushima, M., Okada, N., Ito, T., Aizawa, S., Akahane, R., Umemoto, T., Ueda, K., Kioka, N. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  14. Impact of altered actin gene expression on vinculin, talin, cell spreading, and motility. Schevzov, G., Lloyd, C., Gunning, P. DNA Cell Biol. (1995) [Pubmed]
  15. Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle. Porter, G.A., Dmytrenko, G.M., Winkelmann, J.C., Bloch, R.J. J. Cell Biol. (1992) [Pubmed]
  16. Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculin. Weiss, E.E., Kroemker, M., Rüdiger, A.H., Jockusch, B.M., Rüdiger, M. J. Cell Biol. (1998) [Pubmed]
  17. Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Gallant, N.D., Michael, K.E., García, A.J. Mol. Biol. Cell (2005) [Pubmed]
  18. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. Allen, W.E., Jones, G.E., Pollard, J.W., Ridley, A.J. J. Cell. Sci. (1997) [Pubmed]
  19. The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-delta to focal adhesions. Barry, S.T., Critchley, D.R. J. Cell. Sci. (1994) [Pubmed]
  20. Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Goldmann, W.H., Ingber, D.E. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  21. Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway. Schindeler, A., Lavulo, L., Harvey, R.P. Exp. Cell Res. (2005) [Pubmed]
  22. Absence of interaction between the 165-kDa fibronectin-binding protein involved in mouse odontoblast differentiation and vinculin. Fausser, J.L., Staub, A., Ungewickell, E., Ruch, J.V., Lesot, H. Arch. Oral Biol. (1993) [Pubmed]
  23. Association of polyoma virus middle T antigen and pp60src with cytoskeletal elements. Ballmer-Hofer, K., Ziegler, A., Burger, M.M. Oncogene (1988) [Pubmed]
  24. Plakoglobin is a component of the filamentous subplasmalemmal coat of lens cells. Franke, W.W., Kapprell, H.P., Cowin, P. Eur. J. Cell Biol. (1987) [Pubmed]
  25. Epidermal growth factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss 3T3 cells. Regulation through a protein kinase C-independent pathway. Bellas, R.E., Bendori, R., Farmer, S.R. J. Biol. Chem. (1991) [Pubmed]
  26. Actin cytoskeleton of extraembryonic endoderm and teratocarcinoma-derived endoderm cells. Tienari, J. Exp. Cell Res. (1989) [Pubmed]
  27. Fibrillin-1 regulates mesangial cell attachment, spreading, migration and proliferation. Porst, M., Plank, C., Bieritz, B., Konik, E., Fees, H., Dötsch, J., Hilgers, K.F., Reinhardt, D.P., Hartner, A. Kidney Int. (2006) [Pubmed]
  28. Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells. Zhang, J.S., Kraus, W.E., Truskey, G.A. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  29. Regulation of adherens junction protein expression in growth-activated 3T3 cells and in regenerating liver. Glück, U., Rodríguez Fernández, J.L., Pankov, R., Ben-Ze'ev, A. Exp. Cell Res. (1992) [Pubmed]
  30. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Zhang, J.Q., Elzey, B., Williams, G., Lu, S., Law, D.J., Horowits, R. Biochemistry (2001) [Pubmed]
  31. Differences in elasticity of vinculin-deficient F9 cells measured by magnetometry and atomic force microscopy. Goldmann, W.H., Galneder, R., Ludwig, M., Xu, W., Adamson, E.D., Wang, N., Ezzell, R.M. Exp. Cell Res. (1998) [Pubmed]
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