High impact information on MC5

• Among the five members of the melanocortin receptor (MC-R) family, MC2 and MC5 are expressed in peripheral tissues [1].
• Expression and regulation of melanocortin receptor-5 (MC5-R) in the bovine adrenal cortex [1].
• However, although potentially regulated by hormones, MC5-R is expressed at a level at least 100 times less than MC2-R, suggesting that MC5-R expression might only be at trace levels in grown adults, but could be much higher during embryogenesis [1].
• The aim of this work was to study the sites of MC5-R expression in the bovine adrenal cortex and to compare the regulation of the expression of MC2-R and MC5-R in bovine adrenocortical cells in primary culture [2].

Anatomical context of MC5

• The aim of this work was to study the spatial distribution of MC5-R among the different zones of the bovine adrenal cortex and to analyze the regulation of its expression by its own ligands, ACTH and alpha-MSH and by angiotensin II (AII) [1].

Other interactions of MC5

• Expression of ACTH receptors (MC2-R and MC5-R) in the glomerulosa and the fasciculata-reticularis zones of bovine adrenal cortex [2].

Analytical, diagnostic and therapeutic context of MC5

• Analysis of the expression of MC5-R was obtained by RT-PCR, using total RNA purified from glomerulosa and fasciculata zones of bovine adrenocortical tissue [2].

References