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Gene Review

MC2R  -  melanocortin 2 receptor...

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High impact information on MC2R


Biological context of MC2R

  • Thus, the involvement of protein kinase A and C pathways in ACTH action may be mediated in part by phosphorylation of the ACTH receptor at these motifs [6].
  • We isolated five independent cDNAs of nearly 3000 bp for the bovine ACTH receptor by screening adrenal cortex cDNA libraries with a PCR cloned cDNA fragment [6].
  • However, although potentially regulated by hormones, MC5-R is expressed at a level at least 100 times less than MC2-R, suggesting that MC5-R expression might only be at trace levels in grown adults, but could be much higher during embryogenesis [7].

Anatomical context of MC2R

  • The response of the cultured theca cells was more acute than that of the adrenocortical cells, possibly reflecting the propensity of the LH receptor to desensitize rapidly, unlike the ACTH receptor [8].

Associations of MC2R with chemical compounds


Other interactions of MC2R


  1. Inhibition of aldosterone production by pinacidil in vitro. Pratt, J.H., Rothrock, J.K., Dominguez, J.H. Hypertension (1991) [Pubmed]
  2. Regulation by adrenocorticotropin (ACTH), angiotensin II, transforming growth factor-beta, and insulin-like growth factor I of bovine adrenal cell steroidogenic capacity and expression of ACTH receptor, steroidogenic acute regulatory protein, cytochrome P450c17, and 3beta-hydroxysteroid dehydrogenase. Le Roy, C., Li, J.Y., Stocco, D.M., Langlois, D., Saez, J.M. Endocrinology (2000) [Pubmed]
  3. Both low sodium and high potassium intake increase the level of adrenal angiotensin-II receptor type 1, but not that of adrenocorticotropin receptor. Lehoux, J.G., Bird, I.M., Rainey, W.E., Tremblay, A., Ducharme, L. Endocrinology (1994) [Pubmed]
  4. Identification of a protein in adrenal particulates that binds adrenocorticotropin specifically and with high affinity. Hofmann, K., Stehle, C.J., Finn, F.M. Endocrinology (1988) [Pubmed]
  5. Dual actions of lanthanides on ACTH-inhibited leak K(+) channels. Enyeart, J.J., Xu, L., Enyeart, J.A. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  6. cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor. Raikhinstein, M., Zohar, M., Hanukoglu, I. Biochim. Biophys. Acta (1994) [Pubmed]
  7. Expression and regulation of melanocortin receptor-5 (MC5-R) in the bovine adrenal cortex. Liakos, P., Chambaz, E.M., Feige, J.J., Defaye, G. Mol. Cell. Endocrinol. (2000) [Pubmed]
  8. Acute regulation of the bovine gene for the steroidogenic acute regulatory protein in ovarian theca and adrenocortical cells. Ivell, R., Tillmann, G., Wang, H., Nicol, M., Stewart, P.M., Bartlick, B., Walther, N., Mason, J.I., Morley, S.D. J. Mol. Endocrinol. (2000) [Pubmed]
  9. Cycloheximide enhances ACTH-receptor mRNA through transcriptional and post-transcriptional mechanisms in bovine adrenocortical cells. Penhoat, A., Jaillard, C., Begeot, M., Durand, P., Saez, J.M. Mol. Cell. Endocrinol. (1996) [Pubmed]
  10. Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells. Doghman, M., Delagrange, P., Berthelon, M.C., Durand, P., Naville, D., Bégeot, M. Regul. Pept. (2005) [Pubmed]
  11. Expression of ACTH receptors (MC2-R and MC5-R) in the glomerulosa and the fasciculata-reticularis zones of bovine adrenal cortex. Liakos, P., Chambaz, E.M., Feige, J.J., Defaye, G. Endocr. Res. (1998) [Pubmed]
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