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Gene Review

Mc5r  -  melanocortin 5 receptor

Mus musculus

Synonyms: MC5-R, Melanocortin receptor 5
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Disease relevance of Mc5r

  • There was expression of MC5r in retinal pigment epithelial cells, in the ganglion cell and neural outer plexiform layers of healthy wild type mice retinas [1].
  • Alpha-MSH through the melanocortin 5 receptor (MC5r) mediates induction of CD4+ regulatory T cells that suppress in an antigen specific manner autoimmune disease [1].
  • NDP-MSH treatment promoted preputial hypertrophy, and in MC5R(+/+) mice paired against non-aggressive stimulus opponents it decreased attack latency and increased aggression [2].

Psychiatry related information on Mc5r

  • In heterotypic pairs assessed in the social interaction test (SIT), MC5R-deficient mice exhibited less aggressive behavior and more defensive behavior than their wild-type opponents [3].

High impact information on Mc5r

  • Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides [4].
  • Identification of a widely distributed receptor for ACTH/MSH peptides, the melanocortin-5 receptor (MC5-R), suggested non-steroidally mediated systemic effects of these peptides [4].
  • High levels of MC5-R was found in multiple exocrine tissues, including Harderian, preputial, lacrimal, and sebaceous glands, and was also shown to be required for production and stress-regulated synthesis of porphyrins by the Harderian gland and ACTH/MSH-regulated protein secretion by the lacrimal gland [4].
  • Targeted disruption of the MC5-R produced mice with a severe defect in water repulsion and thermoregulation due to decreased production of sebaceous lipids [4].
  • Using RT-PCR and Northern blot hybridization, high levels of MC2 receptor messenger RNA (mRNA) were found in all adipose tissues examined in the mouse, whereas MC5 receptor mRNA was found in a subset of these [5].

Biological context of Mc5r


Anatomical context of Mc5r


Associations of Mc5r with chemical compounds

  • Our results suggest that activation of the MC5R promotes aggression by increasing farnesene signaling [8].
  • Here we show that MC5R deficiency decreases preputial and urine levels of the sex pheromones, alpha- and beta-farnesene, relative to wild-type mice [8].

Other interactions of Mc5r

  • In the lung, MC2R was expressed from E11.5 to E14.5, but MC5R was not expressed at all [7].
  • Interestingly, Nle4, D-Phe7-alpha-MSH (NDP-MSH), a commonly used synthetic alpha-MSH agonist, was a potent antagonist of the MC5 receptor expressed in the 3T3-L1 cell line [5].
  • Recently, five MC receptors have been identified, three of which, the MC3-R, the MC4-R and the MC5-R, are expressed in the nervous system [9].

Analytical, diagnostic and therapeutic context of Mc5r


  1. Melanocortin 5 receptor and ocular immunity. Taylor, A.W., Kitaichi, N., Biros, D. Cell. Mol. Biol. (Noisy-le-grand) (2006) [Pubmed]
  2. Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression. Morgan, C., Cone, R.D. Behav. Genet. (2006) [Pubmed]
  3. Melanocortin-5 receptor deficiency promotes defensive behavior in male mice. Morgan, C., Thomas, R.E., Cone, R.D. Hormones and behavior. (2004) [Pubmed]
  4. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Chen, W., Kelly, M.A., Opitz-Araya, X., Thomas, R.E., Low, M.J., Cone, R.D. Cell (1997) [Pubmed]
  5. Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Boston, B.A., Cone, R.D. Endocrinology (1996) [Pubmed]
  6. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Haskell-Luevano, C., Lim, S., Yuan, W., Cone, R.D., Hruby, V.J. Peptides (2000) [Pubmed]
  7. Spatial and temporal patterns of expression of melanocortin type 2 and 5 receptors in the fetal mouse tissues and organs. Nimura, M., Udagawa, J., Hatta, T., Hashimoto, R., Otani, H. Anat. Embryol. (2006) [Pubmed]
  8. Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice. Morgan, C., Thomas, R.E., Ma, W., Novotny, M.V., Cone, R.D. Chem. Senses (2004) [Pubmed]
  9. Melanocortin receptors mediate alpha-MSH-induced stimulation of neurite outgrowth in neuro 2A cells. Adan, R.A., van der Kraan, M., Doornbos, R.P., Bär, P.R., Burbach, J.P., Gispen, W.H. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  10. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Labbé, O., Desarnaud, F., Eggerickx, D., Vassart, G., Parmentier, M. Biochemistry (1994) [Pubmed]
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