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Gene Review

Mc5r  -  melanocortin 5 receptor

Rattus norvegicus

Synonyms: MC5-R, Melanocortin receptor 5
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High impact information on Mc5r


Biological context of Mc5r


Anatomical context of Mc5r


Other interactions of Mc5r

  • RT-PCR of rat kidney RNA demonstrated reaction products of the expected size in both cortex and medulla for MC3-R, MC4-R, and MC5-R mRNA; no signal for MC1-R or MC2-R was detected [3].

Analytical, diagnostic and therapeutic context of Mc5r

  • The crude proteins were resolved by SDS-PAGE, transblotted to a nitrocellulose membrane, and probed for MC5-R using anti-receptor rabbit antisera [4].


  1. Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands. van der Kraan, M., Adan, R.A., Entwistle, M.L., Gispen, W.H., Burbach, J.P., Tatro, J.B. Endocrinology (1998) [Pubmed]
  2. Melanocortin-4 receptor messenger RNA expression is up-regulated in the non-damaged striatum following unilateral hypoxic-ischaemic brain injury. Mountjoy, K.G., Guan, J., Elia, C.J., Sirimanne, E.S., Williams, C.E. Neuroscience (1999) [Pubmed]
  3. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney. Ni, X.P., Bhargava, A., Pearce, D., Humphreys, M.H. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  4. Expression of the melanocortin 5 receptor on rat lymphocytes. Akbulut, S., Byersdorfer, C.A., Larsen, C.P., Zimmer, S.L., Humphreys, T.D., Clarke, B.L. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. Binding and processing of (125)I-ACTH by isolated rat splenic lymphocytes. Clarke, B.L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  6. Neural melanocortin receptors are differentially expressed and regulated by stress in rat hypothalamic-pituitary-adrenal axis. Wachira, S.J., Hughes-Darden, C.A., Nicholas, H.B., Taylor, C.V., Robinson, T.J. Cell. Mol. Biol. (Noisy-le-grand) (2004) [Pubmed]
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