High impact information on Mc5r

• MC5-R messenger RNA was found in exocrine glands, including lacrimal, Harderian, preputial, and prostate glands and pancreas, as well as in adrenal gland, esophagus, and thymus, as demonstrated by ribonuclease protection assays [1].
• Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands [1].
• Expression of melanocortin-3 receptor messenger RNA in the brain was not altered in this hypoxic-ischaemic injury model and melanocortin-5 receptor messenger RNA was not detected in either control or hypoxic-ischaemic injured rat brains [2].
• No changes in MC4-R or MC5-R protein expression were observed [3].
• Expression of the melanocortin 5 receptor on rat lymphocytes [4].

Biological context of Mc5r

• These results suggest the lymphocyte ACTH receptor is the Melanocortin 5 receptor and the receptor is internalized by endocytosis to deliver ligand to the lysosome [5].

Anatomical context of Mc5r

• Whereas MC3R and MC5R are expressed in all HPA tissues, MC4R seems to be restricted mainly to the hypothalamus [6].
• Taken together, these findings show that the MC5 receptor is commonly and selectively expressed in exocrine glands and other peripheral organs [1].
• The presence of MC5-R mRNA in spleen and thymus tissues was demonstrated by RT-PCR [4].

Other interactions of Mc5r

• RT-PCR of rat kidney RNA demonstrated reaction products of the expected size in both cortex and medulla for MC3-R, MC4-R, and MC5-R mRNA; no signal for MC1-R or MC2-R was detected [3].

Analytical, diagnostic and therapeutic context of Mc5r

• The crude proteins were resolved by SDS-PAGE, transblotted to a nitrocellulose membrane, and probed for MC5-R using anti-receptor rabbit antisera [4].

References