Disease relevance of GMPR2

• GMP reductase 2 from human has been expressed in Escherichia coli, purified and crystallized [1].

High impact information on GMPR2

• NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties [2].
• The apparent Km of GMPR2 for NADPH and GMP are 26.6 and 17.4 microM, respectively [2].
• Comparison of GMPR2 cDNA sequence with human genome indicates the corresponding gene spans about 6.6kb on chromosome 14, which encodes 348 amino acid residues [2].
• The expression of CD14 and MPO in HL-60 leukemia cells overexpressing GMPR2 clearly increased after induction by TPA [3].
• Northern blotting indicated a ubiquitous expression of GMPR2 mRNA in most of the human tissues and cancer cell lines investigated [3].

Biological context of GMPR2

• METHODS: GMPR2 cDNA was cloned from the cDNA library of human dendritic cells and was characterized by Bioinformatics. The expression pattern of GMPR2 was analyzed by Northern blotting [3].
• Diverse regulations also occurred with proteins involved in cell proliferation and differentiation, such as GMP reductase 2 and creatine kinase B, and proteins bearing potential tumor suppressor activities, including prohibitin and selenium binding protein 1 [4].

Other interactions of GMPR2

• PURPOSE: To identify the biological function of a novel molecule which shows high homology with human guanosine monophosphate reductase (GMPR) and is named GMPR2 [3].

Analytical, diagnostic and therapeutic context of GMPR2

• Purification, crystallization and preliminary X-ray studies of GMP reductase 2 from human [1].

References