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Gene Review

SELENBP1  -  selenium binding protein 1

Homo sapiens

Synonyms: 56 kDa selenium-binding protein, HEL-S-134P, LPSB, SBP, SBP56, ...
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Disease relevance of SELENBP1


Psychiatry related information on SELENBP1


High impact information on SELENBP1

  • Furthermore, the Cnr phenotype results from a spontaneous epigenetic change in the SBP-box promoter [8].
  • Using positional cloning and virus-induced gene silencing, here we demonstrate that an SBP-box (SQUAMOSA promoter binding protein-like) gene resides at the Cnr locus [8].
  • Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia [9].
  • According to our model, 12 amino acid residues lining the Arabidopsis 4CL isoform 2 (At4CL2) substrate binding pocket (SBP) function as a signature motif generally determining 4CL substrate specificity [10].
  • Differential expression and androgen regulation of the human selenium-binding protein gene hSP56 in prostate cancer cells [11].

Chemical compound and disease context of SELENBP1

  • Interestingly, SELENBP1 mRNA and protein levels were reduced by androgen and elevated by selenium treatment in the normal HOSE cells, whereas reversed responses were observed in the ovarian cancer cell lines [3].
  • After 50 weeks of therapy with delapril/manidipine 30mg/10mg once daily, mean SBP/DBP was reduced by 22/14mm Hg in patients with mild to moderate hypertension (n = 309) [12].

Biological context of SELENBP1

  • The hSP56 gene is located at human chromosome 1q21-22) [1].
  • However, systolic BP (SBP) variability also may be induced by fluctuations in stroke volume through left ventricular end-diastolic pressure (LVEDP) variability via dynamic ventricular-arterial coupling during respiration [13].
  • Seven healthy young subjects underwent 6-min recordings of beat-by-beat LVEDP, SBP, and HR in the supine position with controlled respiration at 0.2 Hz during hyper- and hypovolemia [13].
  • Dynamic ventricular-arterial coupling gain (Gain LVEDP-SBP) was smaller by 25% (P = 0.009) during hypervolemia than during hypovolemia, whereas arterial-cardiac baroreflex function gain (Gain SBP-HR) was similar [13].
  • To assess whether a decrease in SBP (systolic blood pressure) or a change in metabolic control would improve the long-axis function, 48 Type II diabetic patients participating in the CALM II (Candesartan and Lisinopril Microalbuminuria II) study were included in the present study [14].

Anatomical context of SELENBP1

  • The results indicate that the membrane of the myeloma cell line SP56 is more suitable for use in the TBII assay than the porcine thyroid membrane, in terms of sensitivity to autoantibodies against TSHR in human sera [15].
  • There were no differences in carotid sinus SBP between PPM-C and PPM-NP during -Gr [16].
  • INTRODUCTION: The push-pull maneuver (PPM) is defined as a reduction in G-tolerance when positive acceleration (+Gz) immediately follows negative acceleration (-Gz) exposure, with the carotid baroreceptors presumably playing a dominant role in the ensuing BP (SBP) responses [16].
  • Tet lowered SBP, left ventricular weight to body weight ratio, vascular media thickness, media to lumen ratio, cardiac and vascular wet weight, and collagen content [17].
  • Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy [18].

Associations of SELENBP1 with chemical compounds

  • Selenium can disrupt the androgen pathway, which has been implicated in modulating SELENBP1 expression [3].
  • In experiments with SBP (6-135 nM), the concentrations of unbound testosterone in the superfusion medium were reduced to the same levels as in the experiments with HSA [19].
  • During the 24-hour period, brimonidine induced a significant decrease in systolic BP (SBP) and DBP at all time points when compared with baseline measurements and with those after administration of the other drugs (P<0.0001) [20].
  • Timolol caused a significant decrease in DBP and SBP at all the 24-hour time points when compared with the baseline and with the dorzolamide- and latanoprost-induced changes (P<0.0001) [20].
  • In nonresponders to monotherapy with delapril (n = 155) or manidipine (n = 152), delapril/manidipine 30mg/10mg once daily for 12 weeks reduced mean SBP/DBP by 16/11mm Hg and 16/10mm Hg, respectively [12].

Other interactions of SELENBP1


Analytical, diagnostic and therapeutic context of SELENBP1


  1. Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. Chang, P.W., Tsui, S.K., Liew, C., Lee, C.C., Waye, M.M., Fung, K.P. J. Cell. Biochem. (1997) [Pubmed]
  2. Localization of selenium-binding protein at the tips of rapidly extending protrusions. Miyaguchi, K. Histochem. Cell Biol. (2004) [Pubmed]
  3. Selenium binding protein 1 in ovarian cancer. Huang, K.C., Park, D.C., Ng, S.K., Lee, J.Y., Ni, X., Ng, W.C., Bandera, C.A., Welch, W.R., Berkowitz, R.S., Mok, S.C., Ng, S.W. Int. J. Cancer (2006) [Pubmed]
  4. Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival. Kim, H., Kang, H.J., You, K.T., Kim, S.H., Lee, K.Y., Kim, T.I., Kim, C., Song, S.Y., Kim, H.J., Lee, C., Kim, H. Proteomics (2006) [Pubmed]
  5. Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity. Silvers, A.L., Lin, L., Bass, A.J., Chen, G., Wang, Z., Thomas, D.G., Lin, J., Giordano, T.J., Orringer, M.B., Beer, D.G., Chang, A.C. Clin. Cancer Res. (2010) [Pubmed]
  6. Is high job strain associated with hypertension genesis? Ducher, M., Cerutti, C., Chatellier, G., Fauvel, J.P. Am. J. Hypertens. (2006) [Pubmed]
  7. Exclusion of influence of physical activity on ambulatory blood pressure. Hayashi, T., Ohshige, K., Tochikubo, O. Clin. Exp. Hypertens. (2007) [Pubmed]
  8. A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Manning, K., Tör, M., Poole, M., Hong, Y., Thompson, A.J., King, G.J., Giovannoni, J.J., Seymour, G.B. Nat. Genet. (2006) [Pubmed]
  9. Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia. Glatt, S.J., Everall, I.P., Kremen, W.S., Corbeil, J., Sásik, R., Khanlou, N., Han, M., Liew, C.C., Tsuang, M.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase. Schneider, K., Hövel, K., Witzel, K., Hamberger, B., Schomburg, D., Kombrink, E., Stuible, H.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Differential expression and androgen regulation of the human selenium-binding protein gene hSP56 in prostate cancer cells. Yang, M., Sytkowski, A.J. Cancer Res. (1998) [Pubmed]
  12. Delapril/manidipine. McCormack, P.L., Keating, G.M. Drugs (2006) [Pubmed]
  13. Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans. Shibata, S., Zhang, R., Hastings, J., Fu, Q., Okazaki, K., Iwasaki, K., Levine, B.D. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  14. Effects of blood pressure lowering and metabolic control on systolic left ventricular function in Type II diabetes mellitus. Andersen, N.H., Poulsen, S.H., Poulsen, P.L., Knudsen, S.T., Helleberg, K., Hansen, K.W., Dinesen, D.S., Eiskjaer, H., Flyvbjerg, A., Mogensen, C.E. Clin. Sci. (2006) [Pubmed]
  15. Expression of recombinant human thyrotropin receptor in myeloma cells. Matsuba, T., Yamada, M., Suzuki, H., Kanai, A., Isozaki, O., Yoshida, T., Tsushima, T., Yasukawa, K. J. Biochem. (1995) [Pubmed]
  16. Carotid sinus pressure changes during push-pull maneuvers. Goodman, L.S., Grosman-Rimon, L., Mikuliszyn, R. Aviation, space, and environmental medicine. (2006) [Pubmed]
  17. Effects of tetrandrine on cardiac and vascular remodeling. Rao, M.R. Acta Pharmacol. Sin. (2002) [Pubmed]
  18. Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy. Torrealba, J.R., Colburn, M., Golner, S., Chang, Z., Scheunemann, T., Fechner, J.H., Roenneburg, D., Hu, H., Alam, T., Kim, H.T., Kanmaz, T., Oberley, T., Knechtle, S.J., Hamawy, M.M. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  19. Influence of purified plasma proteins on testosterone uptake and metabolism by normal and hyperplastic human prostate in "constant-flow organ culture". Mercier-Bodard, C., Marchut, M., Perrot, M., Picard, M.T., Baulieu, E.E., Robel, P. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  20. Effects of topical hypotensive drugs on circadian IOP, blood pressure, and calculated diastolic ocular perfusion pressure in patients with glaucoma. Quaranta, L., Gandolfo, F., Turano, R., Rovida, F., Pizzolante, T., Musig, A., Gandolfo, E. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  21. Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas. Chen, G., Wang, H., Miller, C.T., Thomas, D.G., Gharib, T.G., Misek, D.E., Giordano, T.J., Orringer, M.B., Hanash, S.M., Beer, D.G. J. Pathol. (2004) [Pubmed]
  22. Diverse proteomic alterations in gastric adenocarcinoma. He, Q.Y., Cheung, Y.H., Leung, S.Y., Yuen, S.T., Chu, K.M., Chiu, J.F. Proteomics (2004) [Pubmed]
  23. Horseradish and soybean peroxidases: comparable tools for alternative niches? Ryan, B.J., Carolan, N., O'Fágáin, C. Trends Biotechnol. (2006) [Pubmed]
  24. 7-year stability of blood pressure in the Canadian population. Katzmarzyk, P.T., Rankinen, T., Pérusse, L., Malina, R.M., Bouchard, C. Preventive medicine. (2000) [Pubmed]
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