Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PPHLN1 - periphilin 1

Homo sapiens

Synonyms: Gastric cancer antigen Ga50, HSPC206, HSPC232, Periphilin-1

Kazerounian, S. et al., Huh, J.W. et al., Kurita, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PPHLN1

Molecular evolution of the periphilin gene in relation to human endogenous retrovirus m element [1].

High impact information on PPHLN1

We have identified through yeast two-hybrid screening a novel protein, periphilin, interacting with periplakin, which is known as a precursor of the cornified cell envelope [2].
Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope [2].
Periphilin gene at chromosome 12q12 gives rise to multiple alternatively spliced transcripts [2].
A monoclonal antibody detected the keratinocyte-specific periphilin isoform in undifferentiated keratinocytes in speckle-type nuclear granules and at the nuclear membrane, but in differentiated keratinocytes periphilin localized to the cell periphery and at cell-cell junctions, colocalizing there with periplakin [2].
HERV-M (human endogenous retrovirus M), related to the super family of HERV-K, has a methionine (M) tRNA primer-binding site, and is located within the periphilin gene on human chromosome 12q12 [1].

Biological context of PPHLN1

Analysis of expression of regulators involved in DNA replication has revealed that both mRNA and protein expression of Cdc7, a regulator of the initiation and continuation of DNA replication, are markedly downregulated by overexpression of CR/periphilin [3].
Also, Alusq/x (variant 4-9) and L1ME4a (mammalian-wide subfamilies of LINE-1) (variant 10) in humans and SINE (short interspersed repetitive element) and RLTR15 (the mouse putative long terminal repeat) (variant 2) in mice could be driving forces in transcript diversification of the periphilin gene during mammalian evolution [1].

Associations of PPHLN1 with chemical compounds

From cultured keratinocytes, periphilin was solubilized only after urea extraction, indicating the highly insoluble character of this protein [2].

Regulatory relationships of PPHLN1

Overexpression of CR/periphilin induces S-phase arrest [3].

Other interactions of PPHLN1

We here show that CR/periphilin is a ubiquitously expressed nuclear protein with speckled distribution [3].

References

Molecular evolution of the periphilin gene in relation to human endogenous retrovirus m element. Huh, J.W., Kim, T.H., Yi, J.M., Park, E.S., Kim, W.Y., Sin, H.S., Kim, D.S., Min, D.S., Kim, S.S., Kim, C.B., Hyun, B.H., Kang, S.K., Jung, J.S., Lee, W.H., Takenaka, O., Kim, H.S. J. Mol. Evol. (2006) [Pubmed]
Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. Kazerounian, S., Aho, S. J. Biol. Chem. (2003) [Pubmed]
Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Kurita, M., Suzuki, H., Masai, H., Mizumoto, K., Ogata, E., Nishimoto, I., Aiso, S., Matsuoka, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PPHLN1	Canis lupus familiaris
PPHLN1	Gallus gallus
LOC701728	Macaca mulatta
Pphln1	Mus musculus
PPHLN1	Pan troglodytes
Pphln1	Rattus norvegicus
pphln1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.