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Gene Review

AZIN1  -  antizyme inhibitor 1

Homo sapiens

Synonyms: AZI, AZIA1, Antizyme inhibitor 1, OAZI, OAZIN, ...
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High impact information on AZIN1


Biological context of AZIN1


Associations of AZIN1 with chemical compounds

  • Two distinct phases were involved in the desulfuration of AZIN, DIA, and PAR, characterized by different affinity constants (K(mapp1) = 0.13-9 microM and K(mapp2) = 5- 269 microM) [3].

Other interactions of AZIN1

  • Antizyme 1 has been shown to be negatively regulated through the AZI (antizyme inhibitor) that binds antizyme 1 with higher affinity compared with ODC [6].


  1. Mouse Ornithine Decarboxylase-like Gene Encodes an Antizyme Inhibitor Devoid of Ornithine and Arginine Decarboxylating Activity. L??pez-Contreras, A.J., L??pez-Garcia, C., Jim??nez-Cervantes, C., Cremades, A., Pe??afiel, R. J. Biol. Chem. (2006) [Pubmed]
  2. Molecular basis for the antiproliferative effect of agmatine in tumor cells of colonic, hepatic, and neuronal origin. Wolf, C., Br??ss, M., H??nisch, B., G??thert, M., von K??gelgen, I., Molderings, G.J. Mol. Pharmacol. (2007) [Pubmed]
  3. CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Buratti, F.M., Volpe, M.T., Meneguz, A., Vittozzi, L., Testai, E. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  4. Spray deposition of two insecticides into surface waters in a South African orchard area. Schulz, R., Peall, S.K., Dabrowski, J.M., Reinecke, A.J. J. Environ. Qual. (2001) [Pubmed]
  5. Antizyme inhibitor: a defective ornithine decarboxylase or a physiological regulator of polyamine biosynthesis and cellular proliferation. Keren-Paz, A., Bercovich, Z., Kahana, C. Biochem. Soc. Trans. (2007) [Pubmed]
  6. Regulation of all members of the antizyme family by antizyme inhibitor. Mangold, U., Leberer, E. Biochem. J. (2005) [Pubmed]
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