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Gene Review

Azin1  -  antizyme inhibitor 1

Mus musculus

Synonyms: 1700085L02Rik, AI414949, AZI, Antizyme inhibitor 1, ODC antizyme inhibitor, ...
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Disease relevance of Azin1

  • However, on the B6 background, the AZIP mice have less hyperglycemia, lower circulating triglyceride and fatty acid levels, and lower mortality [1].

High impact information on Azin1

  • Moreover, Az binding actually stabilizes AzI by inhibiting its ubiquitination [2].
  • We show here that like ODC, AzI is also a short-lived protein that undergoes proteasomal degradation [2].
  • B6 wild type, as well as B6 AZIP, mice have increased triglyceride clearance relative to FVB, which may be explained in part by higher serum lipase levels and liver CD36/fatty acid translocase mRNA levels [1].
  • On both the FVB/N (FVB) and C57BL/6J (B6) backgrounds, AZIP mice have a similarly severe lack of white adipose tissue and comparably increased insulin levels and triglyceride secretion rates [1].
  • The metabolic phenotype of the A-ZIP/F-1 (AZIP) lipoatrophic mouse is different depending on its genetic background [1].

Biological context of Azin1


Anatomical context of Azin1


Associations of Azin1 with chemical compounds


Other interactions of Azin1


  1. Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance. Colombo, C., Haluzik, M., Cutson, J.J., Dietz, K.R., Marcus-Samuels, B., Vinson, C., Gavrilova, O., Reitman, M.L. J. Biol. Chem. (2003) [Pubmed]
  2. Degradation of antizyme inhibitor, an ornithine decarboxylase homologous protein, is ubiquitin-dependent and is inhibited by antizyme. Bercovich, Z., Kahana, C. J. Biol. Chem. (2004) [Pubmed]
  3. Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Nilsson, J., Grahn, B., Heby, O. Biochem. J. (2000) [Pubmed]
  4. Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions. Keren-Paz, A., Bercovich, Z., Porat, Z., Erez, O., Brener, O., Kahana, C. Oncogene (2006) [Pubmed]
  5. Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. Kim, S.W., Mangold, U., Waghorne, C., Mobascher, A., Shantz, L., Banyard, J., Zetter, B.R. J. Cell. Sci. (2006) [Pubmed]
  6. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. Gavrilova, O., Haluzik, M., Matsusue, K., Cutson, J.J., Johnson, L., Dietz, K.R., Nicol, C.J., Vinson, C., Gonzalez, F.J., Reitman, M.L. J. Biol. Chem. (2003) [Pubmed]
  7. Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. Satriano, J., Matsufuji, S., Murakami, Y., Lortie, M.J., Schwartz, D., Kelly, C.J., Hayashi, S., Blantz, R.C. J. Biol. Chem. (1998) [Pubmed]
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