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Gene Review

TERT  -  telomerase reverse transcriptase

Bos taurus

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High impact information on TERT

  • Modifications of the structure of MP-6 show that a tert-butyl group on the benzene ring, a methyl group attached to the pyridine nitrogen atom, para-substitution pattern in the pyridine ring, and the presence of a branched structure in the spacer moiety are important for the selective inhibition [1].
  • The tert-butyl glutamic ester initially used at P3 gave plasma unstable, insoluble compounds and was replaced with the better isostere, N-beta-neopentyl asparagine [2].
  • Addition of methyl, methoxy and benzyl groups to phenol did not diminish protective activity of the compound, but addition of one and particularly two tert-butyl groups greatly diminished activity [3].
  • The hydroxyl group in the hydroxycarboxylate residue was determined to be at the omega-position by comparison of the mass spectra of the tert-butyl-dimethylsilyl derivatives of these compounds with those of synthetic hydroxybutyrate-containing phosphatidylcholines [4].

Analytical, diagnostic and therapeutic context of TERT

  • The method involved a simple extraction procedure using tert-butyl methyl ether followed by analysis on the biosensor with results obtained against a buffer calibration curve [5].


  1. Specificity of pyridinium inhibitors of the ubiquinone reduction sites in mitochondrial complex I. Miyoshi, H., Iwata, J., Sakamoto, K., Furukawa, H., Takada, M., Iwamura, H., Watanabe, T., Kodama, Y. J. Biol. Chem. (1998) [Pubmed]
  2. Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. Rydzewski, R.M., Burrill, L., Mendonca, R., Palmer, J.T., Rice, M., Tahilramani, R., Bass, K.E., Leung, L., Gjerstad, E., Janc, J.W., Pan, L. J. Med. Chem. (2006) [Pubmed]
  3. Mode of action of butylated hydroxyanisole (BHA) and other phenols in preventing loss of 11 beta-hydroxylase activity in cultured bovine adrenocortical cells. Hornsby, P.J., Aldern, K.A., Harris, S.E. Biochem. Pharmacol. (1985) [Pubmed]
  4. Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. Tokumura, A., Tanaka, T., Yotsumoto, T., Tsukatani, H. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  5. Determination of clenbuterol residues in bovine urine by optical immunobiosensor assay. Haughey, S.A., Baxter, G.A., Elliott, C.T., Persson, B., Jonson, C., Bjurling, P. Journal of AOAC International. (2001) [Pubmed]
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