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Gene Review:

TERT - telomerase reverse transcriptase

Gallus gallus

Coussens, M. et al., Chang, H. et al., Swanberg, S.E. et al.

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Disease relevance of TERT

To further assess the role of TERT in quiescent PGCs, we developed a chicken Actb gene promoter/cytomegalovirus enhancer (CAG)-Tert transgenic mouse strain that constitutively expresses murine TERT [1].

High impact information on TERT

Further, these results support the body of increasing evidence that alternative splicing of TERT, both in human and chicken, contributes to telomerase activity regulation [2].
Telomerase reverse transcriptase (TERT) is an essential component of the telomerase ribonucleoprotein complex which maintains telomeres [2].
Fluorescence-activated cell-sorting (FACS) analysis of PGC frequency and cell cycle status revealed no effect of either overexpression or deficiency of TERT in CAG-Tert transgenic mice or Tert knock-out mice respectively [1].
We now show, using a Pou5f1-GFP transgenic mouse model, that telomerase suppression in quiescent male primordial germ cells (PGCs) is accompanied by a decrease in expression of murine telomerase reverse transcriptase (TERT) [1].
These results demonstrate that TERT per se does not affect proliferation or development of PGCs, in contrast with recent studies that suggest that TERT has a telomere-independent effect in certain stem cells [1].

Biological context of TERT

This study examined telomerase activity and gene expression profiles for three genes in Gallus gallus domesticus: telomerase reverse transcriptase (chTERT), telomerase RNA (chTR), and c-myc [3].

References

Regulation and effects of modulation of telomerase reverse transcriptase expression in primordial germ cells during development. Coussens, M., Yamazaki, Y., Moisyadi, S., Suganuma, R., Yanagimachi, R., Allsopp, R. Biol. Reprod. (2006) [Pubmed]
Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity. Chang, H., Delany, M.E. Gene (2006) [Pubmed]
Telomerase activity and differential expression of telomerase genes and c-myc in chicken cells in vitro. Swanberg, S.E., Payne, W.S., Hunt, H.D., Dodgson, J.B., Delany, M.E. Dev. Dyn. (2004) [Pubmed]

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