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Gene Review:

Tert - telomerase reverse transcriptase

Rattus norvegicus

Synonyms: Telomerase catalytic subunit, Telomerase reverse transcriptase

Li, H. et al., Liu, T. et al., Hu, B. et al., Xu, S.L. et al.

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Disease relevance of Tert

Effects of hypoxia on promoter of telomerase reverse transcriptase and cell cycle distribution in neonatal rat cardiac myocytes [1].

High impact information on Tert

In this study, the role of Smad3 in the inhibition of telomerase reverse transcriptase (TERT) gene transcription by TGFbeta was investigated [2].
While mutations of all putative Akt phosphorylation sites in telomerase reverse transcriptase (TERT) has no effect on telomerase activity, inhibition of MAP kinase signalling by PD98059 or U0126 abolishes NGF-induced telomerase down-regulation in a concentration-dependent manner [3].

Analytical, diagnostic and therapeutic context of Tert

At selected time points after treatment, the cells were analyzed for telomerase activity, as well as telomerase reverse transcriptase (TERT) mRNA and protein by reverse transcriptase/polymerase chain reaction and Western blot, respectively [4].

References

Effects of hypoxia on promoter of telomerase reverse transcriptase and cell cycle distribution in neonatal rat cardiac myocytes. Xu, S.L., Huang, J., Zhu, J., Cao, K.J., Ding, G.P., Zhu, Y., Xu, L. Chin. Med. J. (2005) [Pubmed]
Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Hu, B., Tack, D.C., Liu, T., Wu, Z., Ullenbruch, M.R., Phan, S.H. Oncogene (2006) [Pubmed]
Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling. Li, H., Pinto, A.R., Duan, W., Li, J., Toh, B.H., Liu, J.P. J. Neurochem. (2005) [Pubmed]
Regulation of telomerase activity in rat lung fibroblasts. Liu, T., Nozaki, Y., Phan, S.H. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]

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