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TERT  -  telomerase reverse transcriptase

Canis lupus familiaris

 
 
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Disease relevance of TERT

 

High impact information on TERT

  • In comparison with guancydine, which is the de-3-pyridyl analogue of 20, a 150-fold increase of potency in spontaneously hypertensive rats was obtained with 20 and its tert-butyl analogue 19 [2].
  • The protective effect of D-glucose was much less marked in tert-butyl hydroperoxide-cytotoxicity [3].
  • Sample pretreatment involved liquid-liquid extraction with tert-butyl methyl ether [4].
  • Samples were analysed by positive ion electrospray ionisation LC/MS on two different instruments and the unknown compound was identified as an N-oxide of the tert. nitrogen atom of the 2-(diethylamino)ethyl substituent on N7 of the theophylline nucleus [5].
  • Expression of TERT mRNA was examined by reverse transcription (RT)-PCR assay [6].
 

Biological context of TERT

  • RESULTS: The canine TERT cDNA clone was 237 base pairs in length and contained a central region encoding the reverse transcriptase motif 2 [6].
  • Still another metabolite is formed by hydroxylation in the tert-butyl group to N-(2-hydroxymethyl-2-propyl)-4,4-diphenyl-2-butylamine [7].
 

Anatomical context of TERT

  • Expression of TERT mRNA was detected in canine tumor cell lines that had telomerase activity but not in telomerase-negative canine primary fibroblasts [6].
  • The TERT mRNA was detected in 13 of 16 canine tumor tissues and several normal tissues such as liver, ovary, lymph node, and thymus [6].
 

Associations of TERT with chemical compounds

  • A series of procaterol derivatives having a tert-amino group was synthesized [8].
  • During development of the extraction procedure, degradation of desbutylhalofantrine was observed under non-acidic conditions in the extraction solvent (tert-butyl methyl ether) and we also report the structural elucidation of the breakdown product and the conditions required to avoid this degradation [9].
  • Oxidative metabolism (phase 1 reactions) mediated by the microsomal monooxygenase system is the major route for BHT degradation; oxidation of the ring methyl group predominates in the rat, rabbit and monkey, and oxidation of the tert-butyl groups in man [10].
  • Diltiazem, clentiazem and their acidic and basic metabolites extractable with tert-butyl methyl ether, which are all 2,3,5-trisubstituted-1,5-benzothiazepines, were analysed by positive ion electron ionization (PIEI) mass spectrometry, and the structures of fragment ions and their fragmentation pathways were investigated [11].
  • New tert-butyl, picolyl and fluorinated analogues of capromorelin (3), a short-acting growth hormone secretagogue (GHS), were prepared as part of a program to identify long-acting GHSs that increase 24-h plasma IGF-1 levels [12].
 

Analytical, diagnostic and therapeutic context of TERT

References

  1. Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationships of new 1-substituted derivatives. Bouzard, D., Di Cesare, P., Essiz, M., Jacquet, J.P., Remuzon, P., Weber, A., Oki, T., Masuyoshi, M. J. Med. Chem. (1989) [Pubmed]
  2. Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. Petersen, H.J., Nielsen, C.K., Arrigoni-Martelli, E. J. Med. Chem. (1978) [Pubmed]
  3. Alloxan toxicity in human and canine spermatozoa. Possible biochemical basis for a species difference in sensitivity. Gorus, F.K., Finsy, R., Pipeleers, D.G. Biochem. Pharmacol. (1986) [Pubmed]
  4. Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection. Stokvis, E., Rosing, H., Causon, R.C., Schellens, J.H., Beijnen, J.H. Journal of mass spectrometry : JMS. (2004) [Pubmed]
  5. N-deethylation and N-oxidation of etamiphylline: identification of etamiphylline-N-oxide in greyhound urine by high performance liquid chromatography-mass spectrometry. Dumasia, M.C., Teale, P. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  6. Molecular cloning of the canine telomerase reverse transcriptase gene and its expression in neoplastic and non-neoplastic cells. Yazawa, M., Okuda, M., Kanaya, N., Hong, S.H., Takahashi, T., Ohashi, E., Nakagawa, T., Nishimura, R., Sasaki, N., Masuda, K., Ohno, K., Tsujimoto, H. Am. J. Vet. Res. (2003) [Pubmed]
  7. Biotransformation of terodiline I. Identification of metabolites in dog urine by mass spectrometry. Norén, B., Stromberg, S., Ericsson, O., Olsson, L.I., Moses, P. Biomed. Mass Spectrom. (1985) [Pubmed]
  8. Synthesis and pharmacological evaluation of procaterol derivatives having a tert-amino group. Yoshizaki, S., Yo, E.Y., Umezato, M., Nakagiri, N., Yabuuchi, Y. Chem. Pharm. Bull. (1989) [Pubmed]
  9. A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions. Humberstone, A.J., Currie, G.J., Porter, C.J., Scanlon, M.J., Charman, W.N. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
  10. Comparative metabolism of BHA, BHT and other phenolic antioxidants and its toxicological relevance. Conning, D.M., Phillips, J.C. Food Chem. Toxicol. (1986) [Pubmed]
  11. Positive ion EI mass spectra of 2,3,5-trisubstituted-1,5-benzothiazepines, diltiazem, clentiazem and their fat-soluble metabolites. Sugawara, Y., Nakamura, S. Journal of pharmaceutical and biomedical analysis. (1994) [Pubmed]
  12. Discovery and biological characterization of capromorelin analogues with extended half-lives. Carpino, P.A., Lefker, B.A., Toler, S.M., Pan, L.C., Hadcock, J.R., Murray, M.C., Cook, E.R., DiBrino, J.N., DeNinno, S.L., Chidsey-Frink, K.L., Hada, W.A., Inthavongsay, J., Lewis, S.K., Mangano, F.M., Mullins, M.A., Nickerson, D.F., Ng, O., Pirie, C.M., Ragan, J.A., Rose, C.R., Tess, D.A., Wright, A.S., Yu, L., Zawistoski, M.P., Pettersen, J.C., DaSilva-Jardine, P.A., Wilson, T.C., Thompson, D.D. Bioorg. Med. Chem. Lett. (2002) [Pubmed]
  13. Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours. Long, S., Argyle, D.J., Nixon, C., Nicholson, I., Botteron, C., Olby, N., Platt, S., Smith, K., Rutteman, G.R., Grinwis, G.C., Nasir, L. Neuropathol. Appl. Neurobiol. (2006) [Pubmed]
 
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