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Gene Review

Tert  -  telomerase reverse transcriptase

Mus musculus

Synonyms: EST2, TCS1, TP2, TR, TRT, ...
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Disease relevance of Tert

  • Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice [1].
  • The radioprotecting effect was also noticed on the inhibition of macrophages migration in the X-ray irradiated rat inoculated with TH Salmonella typhi vaccine and treated with TP2 or with lipidic extract Timosterin B [2].
  • Administration of the TP2 extract containing thymic polypeptides of low molecular weight (under 10,000 daltons) was found to stimulate the delayed hypersensitivity reaction in guinea-pigs injected with BCG [3].

High impact information on Tert


Biological context of Tert


Anatomical context of Tert

  • In the present study, therefore, we attempted to establish human cementoblast-like cell lines by transfection with telomerase catalytic subunit hTERT gene [14].
  • Of the 'latent' viral functions investigated, only one (TP2) of the episomally-specific genes that encode terminal proteins (TP1 and TP2) is found to be expressed in the C15 epithelial cell tumour environment, whereas both are transcribed--as different, but related, messengers--in a B-cell line generated with virus from the C15 tumour [15].
  • Plasmas were incubated in the presence of a purified monoclonal antibody TP2 (Mab TP2) that neutralizes the activity of CETP [16].
  • Expression of mouse telomerase catalytic subunit mTERT gene in testis of SD rats and its significance [17].

Associations of Tert with chemical compounds

  • Tert-butyl ester derivatives of aspartic acid and alanine, and glutamic acid gamma-benzyl ester did not produce seizures [18].
  • The Fab fragments of TP2 caused partial (50%) inhibition of CE transfer and complete inhibition of TG transfer by the CETP [19].

Regulatory relationships of Tert


Other interactions of Tert

  • Here, we demonstrate that the telomerase RNA component Terc is necessary to mediate these effects of Tert overexpression [10].
  • Here, we studied the aging and spontaneous cancer incidence of mice with transgenic telomerase expression in a wide range of adult tissues, K5-Tert mice [11].
  • We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the telomerase reverse transcriptase gene, indicating that embryonic lethality is not the result of telomerase-dependent changes in telomere length or function [21].

Analytical, diagnostic and therapeutic context of Tert


  1. Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Canela, A., Martín-Caballero, J., Flores, J.M., Blasco, M.A. Mol. Cell. Biol. (2004) [Pubmed]
  2. Research on the radioprotecting action of thymic polypeptides and timosterin B. Milcu, S.M., Potop, I., Boeru, V., Briese, M.A., Săvulescu, M. Endocrinologie. (1981) [Pubmed]
  3. Action of thymic polypeptides of low molecular weight on some immune reactions at tissular and humoral level in guinea-pigs and mice. Milcu, S.M., Boeru, V., Prahoveanu, E., Briese, M.A., Petrescu, A., Săvulescu, M. Endocrinologie. (1980) [Pubmed]
  4. Bone marrow-derived progenitor cells in pulmonary fibrosis. Hashimoto, N., Jin, H., Liu, T., Chensue, S.W., Phan, S.H. J. Clin. Invest. (2004) [Pubmed]
  5. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Wege, H., Le, H.T., Chui, M.S., Liu, L., Wu, J., Giri, R., Malhi, H., Sappal, B.S., Kumaran, V., Gupta, S., Zern, M.A. Gastroenterology (2003) [Pubmed]
  6. Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability. Samper, E., Goytisolo, F.A., Ménissier-de Murcia, J., González-Suárez, E., Cigudosa, J.C., de Murcia, G., Blasco, M.A. J. Cell Biol. (2001) [Pubmed]
  7. Impaired germinal center reaction in mice with short telomeres. Herrera, E., Martínez-A, C., Blasco, M.A. EMBO J. (2000) [Pubmed]
  8. Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. Horikawa, I., Chiang, Y.J., Patterson, T., Feigenbaum, L., Leem, S.H., Michishita, E., Larionov, V., Hodes, R.J., Barrett, J.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Genetic analysis of myc and telomerase interactions in vivo. Flores, I., Evan, G., Blasco, M.A. Mol. Cell. Biol. (2006) [Pubmed]
  10. The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. Cayuela, M.L., Flores, J.M., Blasco, M.A. EMBO Rep. (2005) [Pubmed]
  11. Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. González-Suárez, E., Flores, J.M., Blasco, M.A. Mol. Cell. Biol. (2002) [Pubmed]
  12. Effects of telomerase and telomere length on epidermal stem cell behavior. Flores, I., Cayuela, M.L., Blasco, M.A. Science (2005) [Pubmed]
  13. Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Martín-Rivera, L., Herrera, E., Albar, J.P., Blasco, M.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Characterization of established cementoblast-like cell lines from human cementum-lining cells in vitro and in vivo. Kitagawa, M., Tahara, H., Kitagawa, S., Oka, H., Kudo, Y., Sato, S., Ogawa, I., Miyaichi, M., Takata, T. Bone (2006) [Pubmed]
  15. Differential expression of Epstein Barr viral transcripts for two proteins (TP1 and LMP) in lymphocyte and epithelial cells. Smith, P.R., Griffin, B.E. Nucleic Acids Res. (1991) [Pubmed]
  16. Effect of a neutralizing monoclonal antibody to cholesteryl ester transfer protein on the redistribution of apolipoproteins A-IV and E among human lipoproteins. Bisgaier, C.L., Siebenkas, M.V., Hesler, C.B., Swenson, T.L., Blum, C.B., Marcel, Y.L., Milne, R.W., Glickman, R.M., Tall, A.R. J. Lipid Res. (1989) [Pubmed]
  17. Expression of mouse telomerase catalytic subunit mTERT gene in testis of SD rats and its significance. Ye, Z., Chen, X., Yang, S., Chen, J., Xiong, Y., Lu, G. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2003) [Pubmed]
  18. Convulsant properties of L-glutamic acid di-tert butyl ester. Freed, W.J., Ghoz, E.H., Crump, S. Neurobehavioral toxicology and teratology. (1985) [Pubmed]
  19. Mechanism of cholesteryl ester transfer protein inhibition by a neutralizing monoclonal antibody and mapping of the monoclonal antibody epitope. Swenson, T.L., Hesler, C.B., Brown, M.L., Quinet, E., Trotta, P.P., Haslanger, M.F., Gaeta, F.C., Marcel, Y.L., Milne, R.W., Tall, A.R. J. Biol. Chem. (1989) [Pubmed]
  20. Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Armstrong, L., Saretzki, G., Peters, H., Wappler, I., Evans, J., Hole, N., von Zglinicki, T., Lako, M. Stem Cells (2005) [Pubmed]
  21. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Chiang, Y.J., Kim, S.H., Tessarollo, L., Campisi, J., Hodes, R.J. Mol. Cell. Biol. (2004) [Pubmed]
  22. Regulation and effects of modulation of telomerase reverse transcriptase expression in primordial germ cells during development. Coussens, M., Yamazaki, Y., Moisyadi, S., Suganuma, R., Yanagimachi, R., Allsopp, R. Biol. Reprod. (2006) [Pubmed]
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