Disease relevance of ATP6V1C1

• Proton transport by V-ATPases could also play a role during cell transformation, tumorigenesis, and cell metastasis, and V-ATPase c-subunit overexpression was reported to be correlated with invasiveness of pancreatic tumors (Ohta et al., 1996) [1].

High impact information on ATP6V1C1

• Northern analysis of RNA from leaves of plants treated with NaCl or with isoosmotic mannitol solutions demonstrated (i) that NaCl increased steady-state transcript levels for the V-ATPase c subunit, and (ii) that this effect was caused by the ionic rather than the osmotic component of salt stress [2].
• Further, the plant growth regulator abscisic acid (ABA) was able to mimic the effect of salt on transcript levels for the V-ATPase c subunit, suggesting the possible involvement of ABA in a distinct signal-transduction pathway linked to vacuolar salt accumulation in this highly salt-tolerant species [2].
• The clone, pKVA211, was isolated from a K. daigremontiana leaf cDNA library constructed in lambda ZAP II using a homologous PCR-generated cDNA probe for the V-ATPase c subunit [3].
• Particularly unusual is the organization of the atp6 gene in cms-C mitochondria, designated atp6-C [4].
• The atp6-C sequence is a triple gene fusion product comprised of DNAs derived from atp9, atp6 and an open reading frame of unknown origin [4].

Biological context of ATP6V1C1

• These data identify the critical regulatory regions for both the ATP6C and ATP6F basal promoters and stress the functional importance of multiple protein complexes, involving the Sp family of transcription factors, in regulating gene expression [5].
• DNA sequence analysis of the promoters of two V-ATPase subunit genes, encoding C (ATP6C) and c (ATP6F), reveals GC-rich regions in the region of the first exon [5].

Anatomical context of ATP6V1C1

• In cells lacking V(0) genes, Vma2p and Vma5p were still detected on Vid vesicles and vacuoles, suggesting that the distribution of V(1) proteins is independent of V(0) genes [6].

Analytical, diagnostic and therapeutic context of ATP6V1C1

• Sequence comparison of several PCR products and genomic Southern analysis indicated that the V-ATPase c subunit in K. daigremontiana is encoded by a small multi-gene family [3].

References