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Gene Review

CFL1  -  cofilin 1 (non-muscle)

Bos taurus

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Disease relevance of CFL1

  • Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach [1].

High impact information on CFL1

  • A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematical models of the constituent reactions predict the rate of motion [2].
  • After filaments have aged by hydrolysis of their bound ATP and dissociation of the gamma phosphate, ADF/cofilin proteins promote debranching and depolymerization [2].
  • We investigated actin filament turnover rates, length, number, barbed end exposure, and binding of cofilin in bovine arterial endothelial cells moving at different speeds depending on their position in a confluent monolayer [3].
  • Pretreatment of cultures with tautomycin, a protein phosphatase type 1 inhibitor, blocked the effect of cAMP on 1) the dephosphorylation of cofilin, 2) the decrease in RLC phosphorylation, and 3) the decrease in isometric tension [4].
  • Activated cofilin correlates with increased F-actin severing activity in cell extracts from monolayers treated with forskolin/3-isobutyl-1-methylxanthine [4].

Biological context of CFL1


Anatomical context of CFL1


Associations of CFL1 with chemical compounds


  1. Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach. David, V., Gouin, E., Troys, M.V., Grogan, A., Segal, A.W., Ampe, C., Cossart, P. J. Cell. Sci. (1998) [Pubmed]
  2. Cellular motility driven by assembly and disassembly of actin filaments. Pollard, T.D., Borisy, G.G. Cell (2003) [Pubmed]
  3. Regulation of the actin cycle in vivo by actin filament severing. McGrath, J.L., Osborn, E.A., Tardy, Y.S., Dewey, C.F., Hartwig, J.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation. Goeckeler, Z.M., Wysolmerski, R.B. J. Biol. Chem. (2005) [Pubmed]
  5. Cofilin activation during Ca(2+)-triggered secretion from adrenal chromaffin cells. Birkenfeld, J., Kartmann, B., Betz, H., Roth, D. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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