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Gene Review:

GPR84 - G protein-coupled receptor 84

Homo sapiens

Synonyms: EX33, G-protein coupled receptor 84, GPCR4, Inflammation-related G-protein coupled receptor EX33

Wang, J. et al., Yousefi, S. et al.

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Disease relevance of GPR84

The activation of GPR84 by medium-chain FFAs couples primarily to a pertussis toxin-sensitive G(i/o) pathway [1].

High impact information on GPR84

In addition, we show that GPR84 is selectively expressed in leukocytes and markedly induced in monocytes/macrophages upon activation by lipopolysaccharide [1].
Furthermore, we demonstrate that medium-chain FFAs amplify lipopolysaccharide-stimulated production of the proinflammatory cytokine interleukin-12 p40 through GPR84 [1].
Medium-chain FFAs elicit calcium mobilization, inhibit 3',5'-cyclic AMP production, and stimulate [(35)S]guanosine 5'-O-(3-thiotriphosphate) binding in a GPR84-dependent manner [1].
Expression studies of several known chemokine receptors and EX33 revealed that resting neutrophils expressed higher levels of CXCRs and EX33 compared with activated neutrophils [2].
Northern blot experiments revealed that EX33 is expressed mainly in bone marrow, lung, and peripheral blood leukocytes [2].

Anatomical context of GPR84

Using RT-PCR analysis, we showed more abundant expression of EX33 in neutrophils and eosinophils, in comparison with that in T- or B-lymphocytes, indicating cell-specific expression among leukocytes [2].

References

Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84. Wang, J., Wu, X., Simonavicius, N., Tian, H., Ling, L. J. Biol. Chem. (2006) [Pubmed]
Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes. Yousefi, S., Cooper, P.R., Potter, S.L., Mueck, B., Jarai, G. J. Leukoc. Biol. (2001) [Pubmed]

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AgaP_AGAP004930	Anopheles gambiae str. PEST
GPR84	Bos taurus
GPR84	Canis lupus familiaris
gpr84	Danio rerio
Tre1	Drosophila melanogaster
GPR84	Macaca mulatta
Gpr84	Mus musculus
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gpr84	Xenopus (Silurana) tropicalis

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