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Gene Review

POLR2D  -  polymerase (RNA) II (DNA directed)...

Homo sapiens

Synonyms: DNA-directed RNA polymerase II subunit D, DNA-directed RNA polymerase II subunit RPB4, HSRBP4, HSRPB4, RBP4, ...
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High impact information on POLR2D

  • The novel adipocytokines visfatin and retinol-binding protein-4 (RBP-4) have been proposed to influence the development of impaired glucose tolerance [1].
  • Changes in visfatin and RBP-4 were correlated in subjects receiving rosiglitazone (r=-0.64, P<0.01) but not placebo (r=0.12, P=0.15) [1].
  • Reductions in RBP-4 and increases in visfatin may contribute to the pharmacodynamic action of TZD on glucose homeostasis [1].
  • In addition, GAPDH was affinity-purified from S. pombe extract by using an Rpb4/Rpb7-coupled column [2].
  • We now report the results obtained for the last subunit (hRPB4; Mol. Cell. Biol. 18 (1998) 1935-1945) and propose an essentially complete picture of the potential interactions occurring within hRPB [3].

Physical interactions of POLR2D

  • We have complemented the structural analysis with biochemical studies directed at dissecting the RNA-binding properties of the human Rpb4/Rpb7 complex and that of the homologous E/F complex from Methanocaldococcus jannaschii [4].

Other interactions of POLR2D

  • We have obtained crystals of the human Rpb4/Rpb7 heterodimer and determined the structure to 2.7 A resolution [4].
  • We propose that these alternative isoforms function in distinct polymerase complexes, and may influence recruitment of the trypanosome RPB4-RPB7 heterodimer [5].

Analytical, diagnostic and therapeutic context of POLR2D

  • Fasting visfatin, RBP-4, leptin, and adiponectin plasma concentrations were analyzed by immunoassays [1].
  • Treatment with HAART for 12 months resulted in a 6.9-fold and 7.1-fold increase of visfatin and RBP-4 levels (+54.0 +/- 9.7 ng mL(-1), P < 0.0001 and +95.3 +/- 31.7 ng mL(-1), P < 0.01), respectively [6].
  • Plasma visfatin and RBP-4 were determined by ELISA, whereas leptin and adiponectin by RIA [6].


  1. Effect of Rosiglitazone on Visfatin and Retinol-Binding Protein-4 Plasma Concentrations in HIV-Positive Patients. Haider, D.G., Schindler, K., Mittermayer, F., Müller, M., Nowotny, P., Rieger, A., Luger, A., Ludvik, B., Wolzt, M. Clin. Pharmacol. Ther. (2007) [Pubmed]
  2. Glyceraldehyde-3-phosphate dehydrogenase and actin associate with RNA polymerase II and interact with its Rpb7 subunit. Mitsuzawa, H., Kimura, M., Kanda, E., Ishihama, A. FEBS Lett. (2005) [Pubmed]
  3. Interactions between the full complement of human RNA polymerase II subunits. Schaller, S., Grandemange, S., Shpakovski, G.V., Golemis, E.A., Kedinger, C., Vigneron, M. FEBS Lett. (1999) [Pubmed]
  4. Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. Meka, H., Werner, F., Cordell, S.C., Onesti, S., Brick, P. Nucleic Acids Res. (2005) [Pubmed]
  5. An in silico analysis of trypanosomatid RNA polymerases: insights into their unusual transcription. Kelly, S., Wickstead, B., Gull, K. Biochem. Soc. Trans. (2005) [Pubmed]
  6. Impact of antiretroviral therapy on visfatin and retinol-binding protein 4 in HIV-infected subjects. Schindler, K., Haider, D., Wolzt, M., Rieger, A., Gmeinhart, B., Luger, A., Nowotny, P., Ludvik, B. Eur. J. Clin. Invest. (2006) [Pubmed]
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