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Gene Review

NAMPT  -  nicotinamide phosphoribosyltransferase

Homo sapiens

Synonyms: 1110035O14Rik, NAmPRTase, Nampt, Nicotinamide phosphoribosyltransferase, PBEF, ...
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Disease relevance of PBEF1


High impact information on PBEF1


Chemical compound and disease context of PBEF1


Biological context of PBEF1


Anatomical context of PBEF1

  • PBEF itself had no activity but synergized the pre-B-cell colony formation activity of stem cell factor and interleukin 7 [6].
  • The PBEF gene is mainly transcribed in human bone marrow, liver tissue, and muscle [6].
  • Recently, visfatin was identified as an adipokine, which is predominantly secreted from visceral adipose tissue both in humans and mice [2].
  • In addition, we did not find differences in visfatin mRNA expression between visceral and subcutaneous adipose tissue in humans [2].
  • We found no significant correlation between visfatin plasma concentrations and parameters of insulin sensitivity, including fasting insulin, fasting plasma glucose concentrations, and the glucose infusion rate during the steady state of an euglycemic-hyperinsulinemic clamp independent of percent body fat [2].

Associations of PBEF1 with chemical compounds


Regulatory relationships of PBEF1


Other interactions of PBEF1


Analytical, diagnostic and therapeutic context of PBEF1


  1. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. Jia, S.H., Li, Y., Parodo, J., Kapus, A., Fan, L., Rotstein, O.D., Marshall, J.C. J. Clin. Invest. (2004) [Pubmed]
  2. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Berndt, J., Klöting, N., Kralisch, S., Kovacs, P., Fasshauer, M., Schön, M.R., Stumvoll, M., Blüher, M. Diabetes (2005) [Pubmed]
  3. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. Chen, M.P., Chung, F.M., Chang, D.M., Tsai, J.C., Huang, H.F., Shin, S.J., Lee, Y.J. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  4. Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation. Ye, S.Q., Zhang, L.Q., Adyshev, D., Usatyuk, P.V., Garcia, A.N., Lavoie, T.L., Verin, A.D., Natarajan, V., Garcia, J.G. Microvasc. Res. (2005) [Pubmed]
  5. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Nowell, M.A., Richards, P.J., Fielding, C.A., Ognjanovic, S., Topley, N., Williams, A.S., Bryant-Greenwood, G., Jones, S.A. Arthritis Rheum. (2006) [Pubmed]
  6. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Samal, B., Sun, Y., Stearns, G., Xie, C., Suggs, S., McNiece, I. Mol. Cell. Biol. (1994) [Pubmed]
  7. Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Segawa, K., Fukuhara, A., Hosogai, N., Morita, K., Okuno, Y., Tanaka, M., Nakagawa, Y., Kihara, S., Funahashi, T., Komuro, R., Matsuda, M., Shimomura, I. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  8. Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans. Böttcher, Y., Teupser, D., Enigk, B., Berndt, J., Klöting, N., Schön, M.R., Thiery, J., Blüher, M., Stumvoll, M., Kovacs, P. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  9. Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium. Ognjanovic, S., Ku, T.L., Bryant-Greenwood, G.D. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  10. Increased nicotinamide adenine dinucleotide content and synthesis in Plasmodium falciparum-infected human erythrocytes. Zerez, C.R., Roth, E.F., Schulman, S., Tanaka, K.R. Blood (1990) [Pubmed]
  11. Effect of Rosiglitazone on Visfatin and Retinol-Binding Protein-4 Plasma Concentrations in HIV-Positive Patients. Haider, D.G., Schindler, K., Mittermayer, F., Müller, M., Nowotny, P., Rieger, A., Luger, A., Ludvik, B., Wolzt, M. Clin. Pharmacol. Ther. (2007) [Pubmed]
  12. Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men. Sun, G., Bishop, J., Khalili, S., Vasdev, S., Gill, V., Pace, D., Fitzpatrick, D., Randell, E., Xie, Y.G., Zhang, H. Am. J. Clin. Nutr. (2007) [Pubmed]
  13. Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance. Lewandowski, K.C., Stojanovic, N., Press, M., Tuck, S.M., Szosland, K., Bienkiewicz, M., Vatish, M., Lewinski, A., Prelevic, G.M., Randeva, H.S. Diabetologia (2007) [Pubmed]
  14. Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes. Ognjanovic, S., Bryant-Greenwood, G.D. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  15. Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population. Bailey, S.D., Loredo-Osti, J.C., Lepage, P., Faith, J., Fontaine, J., Desbiens, K.M., Hudson, T.J., Bouchard, C., Gaudet, D., P??russe, L., Vohl, M.C., Engert, J.C. Diabetes (2006) [Pubmed]
  16. The release of the adipocytokine visfatin is regulated by glucose and insulin. Haider, D.G., Schaller, G., Kapiotis, S., Maier, C., Luger, A., Wolzt, M. Diabetologia (2006) [Pubmed]
  17. Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation. van der Veer, E., Nong, Z., O'Neil, C., Urquhart, B., Freeman, D., Pickering, J.G. Circ. Res. (2005) [Pubmed]
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