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Gene Review

FAM120C  -  family with sequence similarity 120C

Homo sapiens

Synonyms: CXorf17, Constitutive coactivator of PPAR-gamma-like protein 2, FLJ20506, ORF34, Protein FAM120C, ...
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Disease relevance of FAM120C


High impact information on FAM120C

  • We previously reported that hypoxia activates KSHV lytic replication and that the promoter for open reading frame 34 (ORF34) contains a functional hypoxia-responsive element (HRE) [2].
  • The ORF34-37 promoter region has six consensus HREs [2].
  • Under conditions of hypoxia, the ORF34 promoter was strongly upregulated by HIF-1 alpha and HIF-2 alpha [1].
  • The CXorf17 protein has homology to two other non-annotated human proteins, C9orf10 and BC012177, the sequence similarity between them being strongest across two discrete domains of 250-270 amino acids in the N- and C-terminal parts of their sequences [4].
  • In the Group 2 loci, comparison of the genetic layout at the 5' end revealed differences which included mutations disrupting reading frames in either or both orf34 and orf35 and apparent allelic differences between orf33 homologs that may be sufficient to account for the genetic basis of serovar identity [5].

Biological context of FAM120C


Analytical, diagnostic and therapeutic context of FAM120C


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