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Gene Review

PPP1CA  -  protein phosphatase 1, catalytic subunit,...

Homo sapiens

Synonyms: PP-1A, PP1A, PP1alpha, PPP1A, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
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High impact information on PPP1CA

  • The most likely order for these loci is C1NH-OSBP-(CD5/CD20)-PGA-FTH1-COX8-PYGM -SEA-KRN1-(MTC/P11EH/HSTF1/INT2)-GST3- PPP1A [1].
  • Dinucleotide repeat polymorphism at the PPP1CA locus on 11q13 [2].
  • These data suggest that like the cyclin D1 gene, CCND1, amplification and overexpression of the PP1alpha gene, PPP1CA, may be involved in OSCC tumorigenesis and/or progression [3].
  • The PPP1CA gene, which encodes the catalytic subunit of serine/threonine protein phosphatase protein phosphatase 1alpha (PP1alpha), is also located in 11q13 [3].
  • The difference was even more significant between cell lines with at least three copies of the PPP1CA gene and those with less than three copies of the gene (P=0.00045) [3].

Biological context of PPP1CA


Associations of PPP1CA with chemical compounds

  • Okadaic acid, the PP1A and PP2A Ser/Thr phosphatase inhibitor, increases pp160 phosphorylation induced by Ins and prevents the inhibitory effect of Ang II pre-stimulation [6].

Analytical, diagnostic and therapeutic context of PPP1CA

  • No significant difference was found in PP1L, PP1A, PN2L, FP1L, FP1A, FN2L, and FP3L between ADHD and control group (all P values > .05) [7].


  1. A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci. Richard, C.W., Withers, D.A., Meeker, T.C., Maurer, S., Evans, G.A., Myers, R.M., Cox, D.R. Am. J. Hum. Genet. (1991) [Pubmed]
  2. Dinucleotide repeat polymorphism at the PPP1CA locus on 11q13. Mochizuki, H., Prochazka, M. Hum. Mol. Genet. (1994) [Pubmed]
  3. Gene amplification and overexpression of protein phosphatase 1alpha in oral squamous cell carcinoma cell lines. Hsu, L.C., Huang, X., Seasholtz, S., Potter, D.M., Gollin, S.M. Oncogene (2006) [Pubmed]
  4. Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes. Saadat, M., Mizuno, Y., Kikuchi, K., Yoshida, M.C. Cytogenet. Cell Genet. (1995) [Pubmed]
  5. Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. Barker, H.M., Jones, T.A., da Cruz e Silva, E.F., Spurr, N.K., Sheer, D., Cohen, P.T. Genomics (1990) [Pubmed]
  6. Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes. Villarreal, R.S., Alvarez, S.E., Ayub, M.J., Ciuffo, G.M. Mol. Cell. Biochem. (2006) [Pubmed]
  7. Effect of methylphenidate on auditory event related potential in boys with attention deficit hyperactivity disorder. Ozdag, M.F., Yorbik, O., Ulas, U.H., Hamamcioglu, K., Vural, O. Int. J. Pediatr. Otorhinolaryngol. (2004) [Pubmed]
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