High impact information on PPP1CA

• The most likely order for these loci is C1NH-OSBP-(CD5/CD20)-PGA-FTH1-COX8-PYGM -SEA-KRN1-(MTC/P11EH/HSTF1/INT2)-GST3- PPP1A [1].
• Dinucleotide repeat polymorphism at the PPP1CA locus on 11q13 [2].
• These data suggest that like the cyclin D1 gene, CCND1, amplification and overexpression of the PP1alpha gene, PPP1CA, may be involved in OSCC tumorigenesis and/or progression [3].
• The PPP1CA gene, which encodes the catalytic subunit of serine/threonine protein phosphatase protein phosphatase 1alpha (PP1alpha), is also located in 11q13 [3].
• The difference was even more significant between cell lines with at least three copies of the PPP1CA gene and those with less than three copies of the gene (P=0.00045) [3].

Biological context of PPP1CA

• Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes [4].
• Using fluorescence in situ hybridization method, the gene encoding the protein phosphatase type 1 alpha catalytic subunit (PPP1CA) was localized to human chromosome band 11q13, rat chromosome band 1q43, and mouse chromosome band 7E3-F2 [4].
• A cDNA encoding one isoform (PP1 alpha) of the catalytic subunit of human protein phosphatase 1 has been isolated and used to map the human PP1 alpha gene (PPP1A) to chromosome band 11q13 by analysis of somatic cell hybrids and in situ hybridization [5].
• Relative PP1alpha protein levels were also significantly associated with PPP1CA gene copy number (P=0.014) [3].
• Indeed, some OSCC cell lines had PPP1CA gene amplification, as analysed by fluorescence in situ hybridization [3].

Associations of PPP1CA with chemical compounds

• Okadaic acid, the PP1A and PP2A Ser/Thr phosphatase inhibitor, increases pp160 phosphorylation induced by Ins and prevents the inhibitory effect of Ang II pre-stimulation [6].

Analytical, diagnostic and therapeutic context of PPP1CA

• No significant difference was found in PP1L, PP1A, PN2L, FP1L, FP1A, FN2L, and FP3L between ADHD and control group (all P values > .05) [7].

References