Gene Review:
FGF4 - fibroblast growth factor 4
Homo sapiens
Synonyms:
FGF-4, Fibroblast growth factor 4, HBGF-4, HST, HST-1, ...
- Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer. Ropiquet, F., Giri, D., Kwabi-Addo, B., Mansukhani, A., Ittmann, M. Cancer Res. (2000)
- Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. Suzuki, K., Tokue, A., Kamiakito, T., Kuriki, K., Saito, K., Tanaka, A. Virchows Arch. (2001)
- Inhibition of ductal morphogenesis in the mammary gland of WAP -fgf4 transgenic mice. Astigiano, S., Damonte, P., Barbieri, O. Anat. Embryol. (2003)
- Germ cell cancer. Oliver, R.T. Current opinion in oncology. (1999)
- Growth factors in progression of human esophageal and gastric carcinomas. Yoshida, K., Yasui, W., Ito, H., Tahara, E. Experimental pathology. (1990)
- Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Zúñiga, A., Haramis, A.P., McMahon, A.P., Zeller, R. Nature (1999)
- MMPI assessment of the DSM-III-R histrionic personality disorder. Schotte, C., De Doncker, D., Maes, M., Cluydts, R., Cosyns, P. Journal of personality assessment. (1993)
- FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Niswander, L., Tickle, C., Vogel, A., Booth, I., Martin, G.R. Cell (1993)
- An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Delli Bovi, P., Curatola, A.M., Kern, F.G., Greco, A., Ittmann, M., Basilico, C. Cell (1987)
- Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line. Balaban-Malenbaum, G., Gilbert, F. Science (1977)
- HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity. Yamamoto, H., Ochiya, T., Tamamushi, S., Toriyama-Baba, H., Takahama, Y., Hirai, K., Sasaki, H., Sakamoto, H., Saito, I., Iwamoto, T., Kakizoe, T., Terada, M. Oncogene (2002)
- HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition. Hirai, K., Sasaki, H., Yamamoto, H., Sakamoto, H., Kubota, Y., Kakizoe, T., Terada, M., Ochiya, T. Exp. Cell Res. (2004)
- The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. Wang, P., Branch, D.R., Bali, M., Schultz, G.A., Goss, P.E., Jin, T. Biochem. J. (2003)
- FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas. Maerz, W.J., Baselga, J., Reuter, V.E., Mellado, B., Myers, M.L., Bosl, G.J., Spinella, M.J., Dmitrovsky, E. Oncogene (1998)
- Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer. Yoshida, M.C., Wada, M., Satoh, H., Yoshida, T., Sakamoto, H., Miyagawa, K., Yokota, J., Koda, T., Kakinuma, M., Sugimura, T. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. Bellosta, P., Iwahori, A., Plotnikov, A.N., Eliseenkova, A.V., Basilico, C., Mohammadi, M. Mol. Cell. Biol. (2001)
- Hyperplasia and impaired involution in the mammary gland of transgenic mice expressing human FGF4. Morini, M., Astigiano, S., Mora, M., Ricotta, C., Ferrari, N., Mantero, S., Levi, G., Rossini, M., Barbieri, O. Oncogene (2000)
- Tumoral progression of human breast epithelial cells secreting FGF2 and FGF4. Souttou, B., Gamby, C., Crepin, M., Hamelin, R. Int. J. Cancer (1996)
- FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Dessimoz, J., Opoka, R., Kordich, J.J., Grapin-Botton, A., Wells, J.M. Mech. Dev. (2006)
- Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain. Shamim, H., Mahmood, R., Logan, C., Doherty, P., Lumsden, A., Mason, I. Development (1999)
- Role for amplification and expression of glypican-5 in rhabdomyosarcoma. Williamson, D., Selfe, J., Gordon, T., Lu, Y.J., Pritchard-Jones, K., Murai, K., Jones, P., Workman, P., Shipley, J. Cancer Res. (2007)
- Effect of fresh gas flow on isoflurane concentrations during low-flow anaesthesia. Park, J.Y., Kim, J.H., Kim, W.Y., Chang, M.S., Kim, J.Y., Shin, H.W. J. Int. Med. Res. (2005)
- Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells. Spinella, M.J., Kitareewan, S., Mellado, B., Sekula, D., Khoo, K.S., Dmitrovsky, E. Oncogene (1998)
- Regulation of the FGF-4 gene by a complex distal enhancer that functions in part as an enhanceosome. Luster, T.A., Rizzino, A. Gene (2003)
- Limb mammary syndrome: a new genetic disorder with mammary hypoplasia, ectrodactyly, and other Hand/Foot anomalies maps to human chromosome 3q27. van Bokhoven, H., Jung, M., Smits, A.P., van Beersum, S., Rüschendorf, F., van Steensel, M., Veenstra, M., Tuerlings, J.H., Mariman, E.C., Brunner, H.G., Wienker, T.F., Reis, A., Ropers, H.H., Hamel, B.C. Am. J. Hum. Genet. (1999)
- Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300. Johnson, L.R., Johnson, T.K., Desler, M., Luster, T.A., Nowling, T., Lewis, R.E., Rizzino, A. J. Biol. Chem. (2002)
- High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer. Zaharieva, B.M., Simon, R., Diener, P.A., Ackermann, D., Maurer, R., Alund, G., Knönagel, H., Rist, M., Wilber, K., Hering, F., Schönenberger, A., Flury, R., Jäger, P., Fehr, J.L., Mihatsch, M.J., Gasser, T., Sauter, G., Toncheva, D.I. J. Pathol. (2003)
- Sef is synexpressed with FGFs during chick embryogenesis and its expression is differentially regulated by FGFs in the developing limb. Harduf, H., Halperin, E., Reshef, R., Ron, D. Dev. Dyn. (2005)
- Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. Liu, C.J., Lin, S.C., Chen, Y.J., Chang, K.M., Chang, K.W. Mol. Carcinog. (2006)
- Fusion and amplification of two originally non-syntenic chromosomal regions in a mammary carcinoma cell line. Lafage, M., Pedeutour, F., Marchetto, S., Simonetti, J., Prosperi, M.T., Gaudray, P., Birnbaum, D. Genes Chromosomes Cancer (1992)
- Human RPE cells express the FGFR2IIIc and FGFR3IIIc splice variants and FGF9 as a potential high affinity ligand. Alizadeh, M., Miyamura, N., Handa, J.T., Hjelmeland, L.M. Exp. Eye Res. (2003)
- Vascular endothelial growth factor, epidermal growth factor and fibroblast growth factor-4 and -10 stimulate trophoblast plasminogen activator system and metalloproteinase-9. Anteby, E.Y., Greenfield, C., Natanson-Yaron, S., Goldman-Wohl, D., Hamani, Y., Khudyak, V., Ariel, I., Yagel, S. Mol. Hum. Reprod. (2004)
- Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis. Borg, A., Sigurdsson, H., Clark, G.M., Fernö, M., Fuqua, S.A., Olsson, H., Killander, D., McGurie, W.L. Br. J. Cancer (1991)