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Gene Review:

CRTAC1 - cartilage acidic protein 1

Homo sapiens

Synonyms: 68 kDa chondrocyte-expressed protein, ASPIC, ASPIC1, CEP-68, CEP68, ...

Steck, E. et al., Steck, E. et al., Komori, Y. et al., Komori, Y. et al., Benz, K. et al., et al.

Ladyman, Bonnet, Lourdais, Bradshaw, Naulleau,

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High impact information on CRTAC1

In the search for new marker genes suitable to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture, we have identified and characterized a novel gene called chondrocyte expressed protein-68 (CEP-68), harbouring an N-terminal leader peptide and an epidermal growth factor-like calcium-binding domain [1].
Vascular endothelial growth factor VEGF-like heparin-binding protein from the venom of Vipera aspis aspis (Aspic viper) [2].
The heparin-binding dimeric hypotensive factor (HF) was purified from Vipera aspis aspis (Aspic viper) venom [Komori, Y. and Sugihara, H. (1990) Toxicon 28, 359-369] [2].
Chondrocyte secreted CRTAC1: A glycosylated extracellular matrix molecule of human articular cartilage [3].
Cartilage acidic protein 1 (CRTAC1), a novel human marker which allowed discrimination of human chondrocytes from osteoblasts and mesenchymal stem cells in culture was so far studied only on the RNA-level [3].

Biological context of CRTAC1

Only CRTAC1 expression correlated with 2D/3D switches while the molecular phenotype of native chondrocytes was not restored [4].
Oxygen consumption of gestating Aspic vipers, Vipera aspis (L.), was strongly dependent on body temperature and mass [5].

Anatomical context of CRTAC1

Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes [1].
In summary, CRTAC1 acquired an alternate last exon from the tail-to-tail oriented neighbouring gene in humans resulting in the glycosylated isoform CRTAC1-A which represents a new extracellular matrix molecule of articular cartilage [3].

Associations of CRTAC1 with chemical compounds

1. A factor X activator was isolated from the venom of Vipera aspis aspis (Aspic viper) by gel filtration and ion-exchange chromatography [6].

Analytical, diagnostic and therapeutic context of CRTAC1

CEP-68 defines a new family of proteins and complements collagen type II as a new marker for stem-cell-based chondrogenic tissue engineering [1].

References

Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. Steck, E., Benz, K., Lorenz, H., Loew, M., Gress, T., Richter, W. Biochem. J. (2001) [Pubmed]
Vascular endothelial growth factor VEGF-like heparin-binding protein from the venom of Vipera aspis aspis (Aspic viper). Komori, Y., Nikai, T., Taniguchi, K., Masuda, K., Sugihara, H. Biochemistry (1999) [Pubmed]
Chondrocyte secreted CRTAC1: A glycosylated extracellular matrix molecule of human articular cartilage. Steck, E., Bräun, J., Pelttari, K., Kadel, S., Kalbacher, H., Richter, W. Matrix Biol. (2007) [Pubmed]
Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes. Benz, K., Breit, S., Lukoschek, M., Mau, H., Richter, W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Gestation, thermoregulation, and metabolism in a viviparous snake, Vipera aspis: evidence for fecundity-independent costs. Ladyman, M., Bonnet, X., Lourdais, O., Bradshaw, D., Naulleau, G. Physiol. Biochem. Zool. (2003) [Pubmed]
Isolation and characterization of factor X activator from the venom of Vipera aspis aspis. Komori, Y., Nikai, T., Sugihara, H. Int. J. Biochem. (1990) [Pubmed]

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CRTAC1	Bos taurus
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crtac1b	Danio rerio
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CRTAC1	Macaca mulatta
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