Disease relevance of DDX43

• RESULTS: The HAGE induced a maximum reactive hyperemia decrease of -60.0% after 2 h and a maximum FMD impairment of -35.1% after 4 h, without affecting endothelium-independent vasodilatation [1].
• We report the correlation of SAGE and HAGE expression with clinicopathological features in patients with lung cancer who had undergone surgery [2].
• METHODS: Expression of SAGE and HAGE messenger RNA was evaluated by reverse transcription-polymerase chain reaction (RT-PCR) in 102 lung carcinomas and adjacent histological normal lung samples using LightCycler [2].

Psychiatry related information on DDX43

• Mr. Hage reminds us that along with that decision-making power comes responsibility for the lives of those affected [3].
• The last section of the text, titled "Concluding Thoughts" has one final chapter (by Hage) that appropriately focuses on social justice implications of fostering multicultural competence in mental health and educational settings [4].

High impact information on DDX43

• The corresponding genes were named SAGE and HAGE because they have the same pattern of expression as genes of the MAGE family [5].
• Gene HAGE, which is located on chromosome 6, encodes a putative protein of 648 amino acids [5].
• Gene HAGE is expressed in many tumors of various histological types at a level that is 100-fold higher than the level observed in normal tissues except testis [5].
• RESEARCH DESIGN AND METHODS: Thirteen people with type 2 diabetes were given a heat-processed test meal with a high AGE content (HAGE; 15.100 AGE kU, 580 kcal, 54 g protein, 17 g lipids, and 48 g carbohydrates) before and after a 3-day therapy with benfotiamine (1,050 mg/day) [1].
• Serum markers of endothelial dysfunction and oxidative stress, as well as AGE, increased after HAGE [1].

Chemical compound and disease context of DDX43

• The effects of HAGE on both FMD and reactive hyperemia were completely prevented by benfotiamine [1].

Biological context of DDX43

• This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments [6].

Anatomical context of DDX43

• AIMS: SAGE and HAGE are recently isolated genes, which were thought to be expressed tumour-specifically, and are potentially coding for tumour-specific antigens recognized by T lymphocytes [2].
• HAGE mRNA was found in two normal salivary glands, 11 benign, and eight malignant tumours [7].

Associations of DDX43 with chemical compounds

• Hage, FAHRA; Jack Healy; Merlin C [8].
• LDL pooled from patients on HAGE diet (Db-HAGE-LDL) was more glycated than LDL from the LAGE diet group (Db-LAGE-LDL) (192 versus 92 AGE U/mg apolipoprotein B) and more oxidized (5.7 versus 1.5 nmol malondialdehyde/mg lipoprotein) [9].

Analytical, diagnostic and therapeutic context of DDX43

• Because of this tumor-specific expression, genes SAGE and HAGE ought to encode antigens that could be useful for antitumoral therapeutic vaccination [5].
• Conchal cartilage is an important source of cartilage for the rhinoplasty surgeon [Falces E, Gorney M: Plast Reconstr Surg 50:147, 1972; Hage J: Brit J Plast Surg 18:92, 1965; Juri J et al: Plast Reconstr Surg 63:377, 1979] [10].

References