Disease relevance of TRIM36

• The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis [1].

High impact information on TRIM36

• The TRIM36 is expressed in adult testis, brain, prostate, kidney, heart and lung [1].
• We did not find mutation in the open reading frame of the TRIM36 in cancer cells [1].
• Immunohistochemistry of recombinant and native TRIM36 displays a cytoplasmic, slightly filamentous staining pattern in COS-7 cells [1].
• Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3 [1].
• By PCR cloning using the putative exon (5qex5) specific primers and primers directed to the vector (lambdaZAPII) sequence of human brain and kidney cDNA libraries, we obtained a full-length cDNA of 4074 bp of the new gene RBCC728/TRIM36 (GenBank accession no.) with an ORF coding for a protein of 728 amino acids [1].

Biological context of TRIM36

• The deduced amino acid sequence of human haprin had 91% identity with the mouse ortholog [2].
• Previously, we isolated a novel haploid-germ-cell-specific gene in the mouse; this gene, named haprin, encodes the RING-finger, B-box-type zinc finger and coiled-coil domain (RBCC) motif protein and may be involved in the acrosome reaction [2].

Anatomical context of TRIM36

• Identification of human HAPRIN potentially involved in the acrosome reaction [2].

Analytical, diagnostic and therapeutic context of TRIM36

• Here we report the molecular cloning and characterization of a human haprin ortholog [2].
• Western blot and immunocytochemical analyses detected HAPRIN protein in the testes and sperm [2].

References