Gene Review:
MFN1 - mitofusin 1
Homo sapiens
Synonyms:
FLJ20693, Fzo homolog, Mitofusin-1, Transmembrane GTPase MFN1, hfzo1, ...
- Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. Barsoum, M.J., Yuan, H., Gerencser, A.A., Liot, G., Kushnareva, Y., Gräber, S., Kovacs, I., Lee, W.D., Waggoner, J., Cui, J., White, A.D., Bossy, B., Martinou, J.C., Youle, R.J., Lipton, S.A., Ellisman, M.H., Perkins, G.A., Bossy-Wetzel, E. EMBO J. (2006)
- Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display. Chung, J.G., Yeh, K.T., Wu, S.L., Hsu, N.Y., Chen, G.W., Yeh, Y.W., Ho, H.C. Cancer Res. (2001)
- Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. Neuspiel, M., Zunino, R., Gangaraju, S., Rippstein, P., McBride, H. J. Biol. Chem. (2005)
- Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Legros, F., Lombès, A., Frachon, P., Rojo, M. Mol. Biol. Cell (2002)
- Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. Ishihara, N., Eura, Y., Mihara, K. J. Cell. Sci. (2004)
- Control of mitochondrial morphology by a human mitofusin. Santel, A., Fuller, M.T. J. Cell. Sci. (2001)
- Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. Cartoni, R., Léger, B., Hock, M.B., Praz, M., Crettenand, A., Pich, S., Ziltener, J.L., Luthi, F., Dériaz, O., Zorzano, A., Gobelet, C., Kralli, A., Russell, A.P. J. Physiol. (Lond.) (2005)
- Molecular mechanism of mitochondrial membrane fusion. Griffin, E.E., Detmer, S.A., Chan, D.C. Biochim. Biophys. Acta (2006)
- Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R.J., Fuller, M.T. J. Cell. Sci. (2003)
- Get the balance right: mitofusins roles in health and disease. Santel, A. Biochim. Biophys. Acta (2006)
- What is the biological significance of the two mitofusin proteins present in the outer mitochondrial membrane of mammalian cells? Zorzano, A., Pich, S. IUBMB Life (2006)
- Polymorphism, heteroplasmy, mitochondrial fusion and diabetes. Sato, A., Endo, H., Umetsu, K., Sone, H., Yanagisawa, Y., Saigusa, A., Aita, S., Kagawa, Y. Biosci. Rep. (2003)
- Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Chang, D.T., Reynolds, I.J. Neuroscience (2006)
- Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. Rojo, M., Legros, F., Chateau, D., Lombès, A. J. Cell. Sci. (2002)