Disease relevance of PSBP1

• Prostatein (or rat prostatic steroid binding protein) is a major autoantigen in experimental autoimmune prostatitis [1].

High impact information on PSBP1

• The protein encoded by this cDNA, which we have named mammaglobin, is homologous to a family of secreted proteins that includes rat prostatic steroid-binding protein subunit C3, human Clara cell 10-kilodalton protein, and rabbit uteroglobin [2].
• Prostatic steroid-binding protein. Isolation and characterization of C3 genes [3].
• Prostatic steroid binding protein, whose expression is stimulated by androgens, consists of two subunits: one containing the polypeptides C1 and C3 and the other containing C2 and C3 [4].
• Prostatic luminal cell differentiation and prostatic steroid-binding protein (PBP) gene expression are differentially affected by neonatal castration [5].
• Amino acid sequence analysis identified the purified protein as prostatein or rat prostatic steroid binding protein, a member of the uteroglobin superfamily [1].

Biological context of PSBP1

• The immunosuppressive effect of PSBP is not due to an inherent toxic effect to the cells, since the cell viability was kept intact at the different times of culture studied [6].
• The function of regulatory regions of DNA, which flank the genes for prostatic steroid binding protein, is being analysed by introducing the cloned genes into heterologous cells [7].

Anatomical context of PSBP1

• Also, PSBP was able to inhibit OVA-specific proliferation of lymph node cells from previously primed animals [6].
• Since PSBP is secreted into the seminal fluid (which is itself a potent immunosuppressor) and has strong homology with uteroglobin (which possess an important anti-inflammatory function) our aim was to determine what effect, if any, PSBP would have on the immune system [6].

Other interactions of PSBP1

• Amino acid sequence homology between the C3 chain of rat prostatic steroid binding protein and human alpha 2-macroglobulin [8].

Analytical, diagnostic and therapeutic context of PSBP1

• Moreover, PSBP strongly inhibits the human mixed lymphocyte reaction [6].
• With that purpose in mind we performed mononuclear cell cultures in the presence or absence of purified PSBP and analysed the effect of this protein on different functional parameters [6].

References