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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Prostatitis


Psychiatry related information on Prostatitis

  • We audited the clinical cohort from our dedicated sexual dysfunction clinic to determine the success of prescribed treatment and co-existing prostatitis/male pelvic pain, erectile dysfunction, phosphodiesterase-5 (PDE5) inhibitor use and anxiety [5].

High impact information on Prostatitis


Chemical compound and disease context of Prostatitis

  • For the treatment of bacterial prostatitis, only trimethoprim and the fluoroquinolones possess both the appropriate bactericidal activity and the ability to diffuse into the prostate [10].
  • Treatment of chronic bacterial prostatitis with temafloxacin [11].
  • In preliminary data from the prostatitis study comparing ofloxacin 300 mg given twice daily with carbenicillin 764 mg given every six hours, microbiologic cure rates were 100 percent with both medications [12].
  • Noncomparative data suggest that enoxacin is also an effective agent for the treatment of prostatitis [13].
  • In the pathologically identified regions of chronic prostatitis, MR spectroscopic imaging data in nine of 12 patients demonstrated elevated choline peak and reduced or no citrate, findings that mimic those of cancer [14].

Biological context of Prostatitis


Anatomical context of Prostatitis


Gene context of Prostatitis


Analytical, diagnostic and therapeutic context of Prostatitis


  1. Induction of tissue-specific autoimmune prostatitis with prostatic acid phosphatase immunization: implications for immunotherapy of prostate cancer. Fong, L., Ruegg, C.L., Brockstedt, D., Engleman, E.G., Laus, R. J. Immunol. (1997) [Pubmed]
  2. Treatment of chronic bacterial prostatitis with ciprofloxacin. Results of a one-year follow-up study. Weidner, W., Schiefer, H.G., Dalhoff, A. Am. J. Med. (1987) [Pubmed]
  3. Nitric oxide synthases in normal and benign hyperplastic human prostate: immunohistochemistry and molecular biology. Gradini, R., Realacci, M., Ginepri, A., Naso, G., Santangelo, C., Cela, O., Sale, P., Berardi, A., Petrangeli, E., Gallucci, M., Di Silverio, F., Russo, M.A. J. Pathol. (1999) [Pubmed]
  4. Urovirulence determinants in Escherichia coli strains causing prostatitis. Andreu, A., Stapleton, A.E., Fennell, C., Lockman, H.A., Xercavins, M., Fernandez, F., Stamm, W.E. J. Infect. Dis. (1997) [Pubmed]
  5. Pharmacological treatment for premature ejaculation. Richardson, D., Goldmeier, D. International journal of STD & AIDS. (2005) [Pubmed]
  6. Letter: Trimethoprim-sulfamethoxazole therapy for prostatitis. Meares, E.M., Stamey, T.A. JAMA (1975) [Pubmed]
  7. Allopurinol for prostatitis: where is the evidence? Nickel, J.C., Siemens, D.R., Lundie, M.J. Lancet (1996) [Pubmed]
  8. Symptomatic cure of prostatitis with metronidazole. Lockie, A.C. Lancet (1981) [Pubmed]
  9. Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma. Gupta, S., Hussain, T., MacLennan, G.T., Fu, P., Patel, J., Mukhtar, H. J. Clin. Oncol. (2003) [Pubmed]
  10. Rational antibiotic treatment of outpatient genitourinary infections in a changing environment. David, R.D., DeBlieux, P.M., Press, R. Am. J. Med. (2005) [Pubmed]
  11. Treatment of chronic bacterial prostatitis with temafloxacin. Cox, C.E., Childs, S.J. Am. J. Med. (1991) [Pubmed]
  12. Ofloxacin in the management of complicated urinary tract infections, including prostatitis. Cox, C.E. Am. J. Med. (1989) [Pubmed]
  13. Enoxacin: a reappraisal of its clinical efficacy in the treatment of genitourinary tract infections. Patel, S.S., Spencer, C.M. Drugs (1996) [Pubmed]
  14. Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings--initial observations. Shukla-Dave, A., Hricak, H., Eberhardt, S.C., Olgac, S., Muruganandham, M., Scardino, P.T., Reuter, V.E., Koutcher, J.A., Zakian, K.L. Radiology. (2004) [Pubmed]
  15. Pharmacokinetics of clarithromycin in the prostate: implications for the treatment of chronic abacterial prostatitis. Giannopoulos, A., Koratzanis, G., Giamarellos-Bourboulis, E.J., Panou, C., Adamakis, I., Giamarellou, H. J. Urol. (2001) [Pubmed]
  16. Research in 'prostatitis syndromes': the use of alfuzosin (a new alpha 1-receptor-blocking agent) in patients mainly presenting with micturition complaints of an irritative nature and confirmed urodynamic abnormalities. de la Rosette, J.J., Karthaus, H.F., van Kerrebroeck, P.E., de Boo, T., Debruyne, F.M. Eur. Urol. (1992) [Pubmed]
  17. Seminal oxidative stress in patients with chronic prostatitis. Pasqualotto, F.F., Sharma, R.K., Potts, J.M., Nelson, D.R., Thomas, A.J., Agarwal, A. Urology (2000) [Pubmed]
  18. Polymerase chain reaction amplification of bacterial 16s rRNA genes in prostate biopsies from men without chronic prostatitis. Keay, S., Zhang, C.O., Baldwin, B.R., Alexander, R.B. Urology (1999) [Pubmed]
  19. The role of lomefloxacin in the treatment of chronic prostatitis. Scelzi, S., Travaglini, F., Nerozzi, S., Dominici, A., Ponchietti, R., Novelli, A., Rizzo, M. Journal of chemotherapy (Florence, Italy) (2001) [Pubmed]
  20. Distribution of quinoline carboxylic acid derivatives in the dog prostate. Jensen, K.M., Madsen, P.O. Prostate (1983) [Pubmed]
  21. Evidence for a mechanistic association between nonbacterial prostatitis and levels of urate and creatinine in expressed prostatic secretion. Persson, B.E., Ronquist, G. J. Urol. (1996) [Pubmed]
  22. Experimental prostatitis in nonhuman primates: I. Bacterial adherence in the urethra. Dilworth, J.P., Neal, D.E., Fussell, E.N., Roberts, J.A. Prostate (1990) [Pubmed]
  23. Penicillanic acid derivatives in the canine prostate. Nielsen, O.S., Frimodt-Moeller, N., Maigaard, S., Hoyme, U., Baumueller, A., Madsen, P.O. Prostate (1980) [Pubmed]
  24. Development of a mouse model for nonbacterial prostatitis. Keetch, D.W., Humphrey, P., Ratliff, T.L. J. Urol. (1994) [Pubmed]
  25. Prostatic specific antigen. el-Shirbiny, A.M. Advances in clinical chemistry. (1994) [Pubmed]
  26. COX-1 and -2 Expressions in Sex-Related Organs of Neonatally Estrogen-Treated Rats and in Activated and Nonactivated Macrophage RAW264.7 Cells with Phytoestrogen. Luo, C., Peng, Y., Santti, R., He, M.L., Lin, M.C. Endocrine (2006) [Pubmed]
  27. IL-1ra versus IL-1 levels in prostatic fluid from prostatitis patients. Nishimura, T., Abe, H., Ito, H., Ikeda, K., Oka, F., Yamamoto, M. Urologia internationalis. (1998) [Pubmed]
  28. Virulence characteristics of Escherichia coli in acute bacterial prostatitis. Mitsumori, K., Terai, A., Yamamoto, S., Ishitoya, S., Yoshida, O. J. Infect. Dis. (1999) [Pubmed]
  29. The effect of digital rectal examination on the serum prostate specific antigen concentration: results of a randomized study. Chybowski, F.M., Bergstralh, E.J., Oesterling, J.E. J. Urol. (1992) [Pubmed]
  30. Immunohistochemical demonstration of Chlamydial antigens in association with prostatitis. Shurbaji, M.S., Gupta, P.K., Myers, J. Mod. Pathol. (1988) [Pubmed]
  31. Distribution and mobility of the tetracycline resistance determinant tetQ. Leng, Z., Riley, D.E., Berger, R.E., Krieger, J.N., Roberts, M.C. J. Antimicrob. Chemother. (1997) [Pubmed]
  32. IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. Nadler, R.B., Koch, A.E., Calhoun, E.A., Campbell, P.L., Pruden, D.L., Bennett, C.L., Yarnold, P.R., Schaeffer, A.J. J. Urol. (2000) [Pubmed]
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