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Gene Review:

Rec8 - REC8 meiotic recombination protein

Mus musculus

Synonyms: AW546880, Cohesin Rec8p, Mei8, Meiotic recombination protein REC8 homolog, Rec8L1, ...

Pigozzi, M.I. et al., Huo, L.J. et al., Iwai, T. et al., Lee, J. et al., Lee, J. et al., et al.

Lee, Iwai, Yokota, Yamashita, Lee, Yokota, Yamashita,

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High impact information on Rec8L1

Thus, Rad21 cannot be considered a 'mitotic'-specific variant, but coexists with Rec8 [1].
We report here the first evidence of the involvement of Rec8 protein, a mammalian homolog of yeast Rec8p, in meiosis-specific chromosome behavior in mammals [2].
Furthermore, Rec8p labeling is lost from autosomal bivalents prior to metaphase I [3].
Differential immunolocalization of a putative Rec8p in meiotic autosomes and sex chromosomes of triatomine bugs [3].
We show that while Rec8p is colocalized with SCs in the autosomes, no Rec8p can be found by immunolabeling in the sex chromosomes at any stage of meiosis [3].

Biological context of Rec8L1

Rec8 protein was present in germinal vesicle-stage oocytes and remained until metaphase I, while it was decreased at anaphase I [4].

Anatomical context of Rec8L1

We also discuss the cooperative functions of Rad21 and Rec8 on the basis of the finding that their mRNAs are coexpressed in oocytes and spermatids [5].

Other interactions of Rec8L1

Actually, several meiosis-specific cohesin subunits, including Rec8, STAG3 and SMC1beta, are known to exist in mammals; however, there are no reports of meiosis-specific cohesin subunits in other vertebrates [6].

Analytical, diagnostic and therapeutic context of Rec8L1

Microinjection of securin antibody into MII-arrested oocytes leads to the degradation of Rec8 [4].

References

Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I. Parra, M.T., Viera, A., Gómez, R., Page, J., Benavente, R., Santos, J.L., Rufas, J.S., Suja, J.A. J. Cell. Sci. (2004) [Pubmed]
Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. Lee, J., Iwai, T., Yokota, T., Yamashita, M. J. Cell. Sci. (2003) [Pubmed]
Differential immunolocalization of a putative Rec8p in meiotic autosomes and sex chromosomes of triatomine bugs. Pigozzi, M.I., Solari, A.J. Chromosoma (2003) [Pubmed]
Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition. Huo, L.J., Zhong, Z.S., Liang, C.G., Wang, Q., Yin, S., Ai, J.S., Yu, L.Z., Chen, D.Y., Schatten, H., Sun, Q.Y. Front. Biosci. (2006) [Pubmed]
Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice. Lee, J., Yokota, T., Yamashita, M. Zool. Sci. (2002) [Pubmed]
Changes in the expression and localization of cohesin subunits during meiosis in a non-mammalian vertebrate, the medaka fish. Iwai, T., Lee, J., Yoshii, A., Yokota, T., Mita, K., Yamashita, M. Gene Expr. Patterns (2004) [Pubmed]

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