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Gene Review

Rec8  -  REC8 meiotic recombination protein

Mus musculus

Synonyms: AW546880, Cohesin Rec8p, Mei8, Meiotic recombination protein REC8 homolog, Rec8L1, ...
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High impact information on Rec8L1

  • Thus, Rad21 cannot be considered a 'mitotic'-specific variant, but coexists with Rec8 [1].
  • We report here the first evidence of the involvement of Rec8 protein, a mammalian homolog of yeast Rec8p, in meiosis-specific chromosome behavior in mammals [2].
  • Furthermore, Rec8p labeling is lost from autosomal bivalents prior to metaphase I [3].
  • Differential immunolocalization of a putative Rec8p in meiotic autosomes and sex chromosomes of triatomine bugs [3].
  • We show that while Rec8p is colocalized with SCs in the autosomes, no Rec8p can be found by immunolabeling in the sex chromosomes at any stage of meiosis [3].

Biological context of Rec8L1


Anatomical context of Rec8L1

  • We also discuss the cooperative functions of Rad21 and Rec8 on the basis of the finding that their mRNAs are coexpressed in oocytes and spermatids [5].

Other interactions of Rec8L1

  • Actually, several meiosis-specific cohesin subunits, including Rec8, STAG3 and SMC1beta, are known to exist in mammals; however, there are no reports of meiosis-specific cohesin subunits in other vertebrates [6].

Analytical, diagnostic and therapeutic context of Rec8L1


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