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Gene Review

Rad21  -  RAD21 homolog (S. pombe)

Mus musculus

Synonyms: Double-strand-break repair protein rad21 homolog, Hr21, PW29, Pokeweed agglutinin-binding protein 29, SCC1, ...
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Disease relevance of Rad21

  • Using antibodies against pokeweed agglutinin-binding proteins from F9 embryonal carcinoma cells, we isolated a cDNA clone PW29 reacting with the antibody. mRNA hybridizing with the cDNA was 4.7 kb, and was strongly expressed in the testis, brain, kidney and heart as well as in F9 cells [1].

High impact information on Rad21


Biological context of Rad21

  • A new role for the mitotic RAD21/SCC1 cohesin in meiotic chromosome cohesion and segregation in the mouse [4].
  • Importantly, RAD21/SCC1 is lost from chromosome arms in late prophase I but persists on centromeres [4].
  • The mSMCB and mSMCD proteins, as well as the PW29 protein, a mouse homolog of Mcd1pS.c./Rad21S.p., form a complex similar to cohesin in X. laevis. mSMCB, mSMCD and PW29 protein levels show no significant cell-cycle dependence [5].

Anatomical context of Rad21


Other interactions of Rad21


  1. cDNA cloning and sequence analysis of a novel calcium binding protein with oligoproline motif. Yu, S., Ozawa, M., Naved, A.F., Miyauchi, T., Muramatsu, H., Muramatsu, T. Cell Struct. Funct. (1995) [Pubmed]
  2. The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. Kumada, K., Yao, R., Kawaguchi, T., Karasawa, M., Hoshikawa, Y., Ichikawa, K., Sugitani, Y., Imoto, I., Inazawa, J., Sugawara, M., Yanagida, M., Noda, T. J. Cell Biol. (2006) [Pubmed]
  3. Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I. Parra, M.T., Viera, A., Gómez, R., Page, J., Benavente, R., Santos, J.L., Rufas, J.S., Suja, J.A. J. Cell. Sci. (2004) [Pubmed]
  4. A new role for the mitotic RAD21/SCC1 cohesin in meiotic chromosome cohesion and segregation in the mouse. Xu, H., Beasley, M., Verschoor, S., Inselman, A., Handel, M.A., McKay, M.J. EMBO Rep. (2004) [Pubmed]
  5. Characterization of the components of the putative mammalian sister chromatid cohesion complex. Darwiche, N., Freeman, L.A., Strunnikov, A. Gene (1999) [Pubmed]
  6. Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice. Lee, J., Yokota, T., Yamashita, M. Zool. Sci. (2002) [Pubmed]
  7. Changes in the expression and localization of cohesin subunits during meiosis in a non-mammalian vertebrate, the medaka fish. Iwai, T., Lee, J., Yoshii, A., Yokota, T., Mita, K., Yamashita, M. Gene Expr. Patterns (2004) [Pubmed]
  8. Syngeneic antiserum to Nulli SCC1 embryonal carcinoma cells recognizing surface antigens of embryonic cells. Hahnel, A.C., Eddy, E.M. J. Reprod. Immunol. (1983) [Pubmed]
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