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Gene Review

Smc1b  -  structural maintenance of chromosomes 1B

Mus musculus

Synonyms: SMC protein 1B, SMC-1-beta, SMC-1B, SMC1beta, Smc1l2, ...
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High impact information on Smc1b


Biological context of Smc1b

  • Meiosis-specific components of the cohesin complex, including the recently described SMC1 isoform SMC1 beta, were suggested to be required for meiotic sister chromatid cohesion and DNA recombination [2].
  • Transcriptional repression of SMC1beta and STAG3 by E2F6 involves multiple mechanisms, including methylation of histone H3 on lysine 9 and lysine 27 [3].
  • SMC1beta was localized along the chromosomal arms as well as on the centromeres in meiotic prophase I, and its existence on the chromosomes persisted up to metaphase II, a situation different from that reported in the mouse, in which SMC1beta is lost from the chromosome arms in late pachytene despite its universal presence in vertebrates [4].

Anatomical context of Smc1b


Other interactions of Smc1b

  • Actually, several meiosis-specific cohesin subunits, including Rec8, STAG3 and SMC1beta, are known to exist in mammals; however, there are no reports of meiosis-specific cohesin subunits in other vertebrates [4].


  1. SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction. Hodges, C.A., Revenkova, E., Jessberger, R., Hassold, T.J., Hunt, P.A. Nat. Genet. (2005) [Pubmed]
  2. Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination. Revenkova, E., Eijpe, M., Heyting, C., Hodges, C.A., Hunt, P.A., Liebe, B., Scherthan, H., Jessberger, R. Nat. Cell Biol. (2004) [Pubmed]
  3. Silencing of the meiotic genes SMC1beta and STAG3 in somatic cells by E2F6. Storre, J., Schäfer, A., Reichert, N., Barbero, J.L., Hauser, S., Eilers, M., Gaubatz, S. J. Biol. Chem. (2005) [Pubmed]
  4. Changes in the expression and localization of cohesin subunits during meiosis in a non-mammalian vertebrate, the medaka fish. Iwai, T., Lee, J., Yoshii, A., Yokota, T., Mita, K., Yamashita, M. Gene Expr. Patterns (2004) [Pubmed]
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