Gene Review:
Pttg1 - pituitary tumor-transforming gene 1
Mus musculus
Synonyms:
AW555095, C87862, PTTG, Pituitary tumor-transforming gene 1 protein, Pttg, ...
- Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Mei, J., Huang, X., Zhang, P. Curr. Biol. (2001)
- Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Wang, Z., Yu, R., Melmed, S. Mol. Endocrinol. (2001)
- TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway. Rajamannan, N.M., Subramaniam, M., Abraham, T.P., Vasile, V.C., Ackerman, M.J., Monroe, D.G., Chew, T.L., Spelsberg, T.C. J. Cell. Biochem. (2007)
- Suppression of lung cancer with siRNA targeting PTTG. Kakar, S.S., Malik, M.T. Int. J. Oncol. (2006)
- Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. Yu, R., Cruz-Soto, M., Calzi, S.L., Hui, H., Melmed, S. J. Endocrinol. (2006)
- Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Homer, H.A., McDougall, A., Levasseur, M., Yallop, K., Murdoch, A.P., Herbert, M. Genes Dev. (2005)
- Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1. Herbert, M., Levasseur, M., Homer, H., Yallop, K., Murdoch, A., McDougall, A. Nat. Cell Biol. (2003)
- Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. Wirth, K.G., Wutz, G., Kudo, N.R., Desdouets, C., Zetterberg, A., Taghybeeglu, S., Seznec, J., Ducos, G.M., Ricci, R., Firnberg, N., Peters, J.M., Nasmyth, K. J. Cell Biol. (2006)
- Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Wang, Z., Moro, E., Kovacs, K., Yu, R., Melmed, S. Proc. Natl. Acad. Sci. U.S.A. (2003)
- PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes. Cristina, C., Díaz-Torga, G.S., Goya, R.G., Kakar, S.S., Perez-Millán, M.I., Passos, V.Q., Giannella-Neto, D., Bronstein, M.D., Becu-Villalobos, D. Mol. Cancer (2007)
- Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Donangelo, I., Gutman, S., Horvath, E., Kovacs, K., Wawrowsky, K., Mount, M., Melmed, S. Endocrinology (2006)
- Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Huang, X., Hatcher, R., York, J.P., Zhang, P. Mol. Biol. Cell (2005)
- The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity. Terret, M.E., Wassmann, K., Waizenegger, I., Maro, B., Peters, J.M., Verlhac, M.H. Curr. Biol. (2003)
- Differential mitotic checkpoint protein requirements in somatic and germ cells. Jeganathan, K.B., van Deursen, J.M. Biochem. Soc. Trans. (2006)
- Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition. Huo, L.J., Zhong, Z.S., Liang, C.G., Wang, Q., Yin, S., Ai, J.S., Yu, L.Z., Chen, D.Y., Schatten, H., Sun, Q.Y. Front. Biosci. (2006)
- Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes. Homer, H.A., McDougall, A., Levasseur, M., Murdoch, A.P., Herbert, M. Reproduction (2005)
- Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity. Madgwick, S., Nixon, V.L., Chang, H.Y., Herbert, M., Levasseur, M., Jones, K.T. Dev. Biol. (2004)
- The RING-H2-finger protein APC11 as a target of hydrogen peroxide. Chang, T.S., Jeong, W., Lee, D.Y., Cho, C.S., Rhee, S.G. Free Radic. Biol. Med. (2004)
- Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway. Chao, J.I., Hsu, S.H., Tsou, T.C. Toxicol. Sci. (2006)
- Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Jeganathan, K.B., Baker, D.J., van Deursen, J.M. Cell Cycle (2006)
- Expression of PTTG and prc1 genes during telencephalic neurogenesis. Tarabykin, V., Britanova, O., Fradkov, A., Voss, A., Katz, L.S., Lukyanov, S., Gruss, P. Mech. Dev. (2000)