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Gene Review

Pttg1  -  pituitary tumor-transforming gene 1

Mus musculus

Synonyms: AW555095, C87862, PTTG, Pituitary tumor-transforming gene 1 protein, Pttg, ...
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Disease relevance of Pttg1


High impact information on Pttg1


Chemical compound and disease context of Pttg1

  • CONCLUSION: We conclude that PTTG does not correlate with prolactin levels or tumor size in animal models of prolactinoma, and its pituitary content is not related to a decrease in dopaminergic control of the lactotrope, but may be influenced by estrogen action at the pituitary level [10].
  • Mice with Pttg inactivation exhibit pituitary hypoplasia, whereas targeted pituitary PTTG overexpression driven by alpha-subunit glycoprotein (alphaGSU) promoter results in focal pituitary hyperplasia [11].

Biological context of Pttg1


Anatomical context of Pttg1


Associations of Pttg1 with chemical compounds

  • Here we show that PTTG disruption in mice (PTTG-/-) severely impairs glucose homeostasis leading to diabetes during late adulthood, especially in males associated with nonautoimmune insulinopenia and reversed alphabeta cell ratio [9].
  • Here we show that stabilisation of cyclin B in nocodazole can be sustained for several hours and is associated with stabilisation of securin [16].
  • Because Ca(2+) spiking was not inhibited by Delta 90 cyclin B1, the degradation timing of securin, visualized by coupling it to EGFP, was unaffected [17].
  • The release of HeLa cells from metaphase arrest in the presence of exogenous H(2)O(2) inhibited the ubiquitination of cyclin B1 as well as the degradation of cyclin B1 and securin that were apparent in the absence of H(2)O(2) [18].
  • Concomitantly, arsenite markedly diminished the securin protein expression and induced the abnormal sister chromatid separation [19].

Physical interactions of Pttg1


Regulatory relationships of Pttg1


Other interactions of Pttg1

  • Although securin/separase/cohesion pathway was reported to regulate chromosome segregation during meiotic metaphase-to-anaphase transition, little biochemical evidence was provided [15].
  • Most of the cells expressing the PTTG gene were found in the lower part of the ventricular zone suggesting that the level of PTTG mRNA is regulated during different phases of the mitotic cycle [21].
  • Besides, arsenite decreased the levels of securin proteins to a similar degree in both the p53-functional and -mutational cells [19].

Analytical, diagnostic and therapeutic context of Pttg1


  1. Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Mei, J., Huang, X., Zhang, P. Curr. Biol. (2001) [Pubmed]
  2. Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Wang, Z., Yu, R., Melmed, S. Mol. Endocrinol. (2001) [Pubmed]
  3. TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway. Rajamannan, N.M., Subramaniam, M., Abraham, T.P., Vasile, V.C., Ackerman, M.J., Monroe, D.G., Chew, T.L., Spelsberg, T.C. J. Cell. Biochem. (2007) [Pubmed]
  4. Suppression of lung cancer with siRNA targeting PTTG. Kakar, S.S., Malik, M.T. Int. J. Oncol. (2006) [Pubmed]
  5. Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. Yu, R., Cruz-Soto, M., Calzi, S.L., Hui, H., Melmed, S. J. Endocrinol. (2006) [Pubmed]
  6. Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Homer, H.A., McDougall, A., Levasseur, M., Yallop, K., Murdoch, A.P., Herbert, M. Genes Dev. (2005) [Pubmed]
  7. Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1. Herbert, M., Levasseur, M., Homer, H., Yallop, K., Murdoch, A., McDougall, A. Nat. Cell Biol. (2003) [Pubmed]
  8. Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. Wirth, K.G., Wutz, G., Kudo, N.R., Desdouets, C., Zetterberg, A., Taghybeeglu, S., Seznec, J., Ducos, G.M., Ricci, R., Firnberg, N., Peters, J.M., Nasmyth, K. J. Cell Biol. (2006) [Pubmed]
  9. Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Wang, Z., Moro, E., Kovacs, K., Yu, R., Melmed, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes. Cristina, C., Díaz-Torga, G.S., Goya, R.G., Kakar, S.S., Perez-Millán, M.I., Passos, V.Q., Giannella-Neto, D., Bronstein, M.D., Becu-Villalobos, D. Mol. Cancer (2007) [Pubmed]
  11. Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Donangelo, I., Gutman, S., Horvath, E., Kovacs, K., Wawrowsky, K., Mount, M., Melmed, S. Endocrinology (2006) [Pubmed]
  12. Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Huang, X., Hatcher, R., York, J.P., Zhang, P. Mol. Biol. Cell (2005) [Pubmed]
  13. The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity. Terret, M.E., Wassmann, K., Waizenegger, I., Maro, B., Peters, J.M., Verlhac, M.H. Curr. Biol. (2003) [Pubmed]
  14. Differential mitotic checkpoint protein requirements in somatic and germ cells. Jeganathan, K.B., van Deursen, J.M. Biochem. Soc. Trans. (2006) [Pubmed]
  15. Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition. Huo, L.J., Zhong, Z.S., Liang, C.G., Wang, Q., Yin, S., Ai, J.S., Yu, L.Z., Chen, D.Y., Schatten, H., Sun, Q.Y. Front. Biosci. (2006) [Pubmed]
  16. Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes. Homer, H.A., McDougall, A., Levasseur, M., Murdoch, A.P., Herbert, M. Reproduction (2005) [Pubmed]
  17. Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity. Madgwick, S., Nixon, V.L., Chang, H.Y., Herbert, M., Levasseur, M., Jones, K.T. Dev. Biol. (2004) [Pubmed]
  18. The RING-H2-finger protein APC11 as a target of hydrogen peroxide. Chang, T.S., Jeong, W., Lee, D.Y., Cho, C.S., Rhee, S.G. Free Radic. Biol. Med. (2004) [Pubmed]
  19. Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway. Chao, J.I., Hsu, S.H., Tsou, T.C. Toxicol. Sci. (2006) [Pubmed]
  20. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Jeganathan, K.B., Baker, D.J., van Deursen, J.M. Cell Cycle (2006) [Pubmed]
  21. Expression of PTTG and prc1 genes during telencephalic neurogenesis. Tarabykin, V., Britanova, O., Fradkov, A., Voss, A., Katz, L.S., Lukyanov, S., Gruss, P. Mech. Dev. (2000) [Pubmed]
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