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Gene Review:

REC8 - REC8 meiotic recombination protein

Homo sapiens

Synonyms: Cohesin Rec8p, HR21spB, Meiotic recombination protein REC8 homolog, REC8L1, Rec8p, ...

Klein, F. et al., Parisi, S. et al., Bhatt, A.M. et al., Gómez, R. et al., Prieto, I. et al., et al.

Klein, Mahr, Galova, Buonomo, Michaelis, Nairz, Nasmyth, Bhatt, Lister, Page, Fransz, Findlay, Jones, Dickinson, Dean,

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High impact information on REC8

We show here that Smc3p and a meiotic version of Scc1p called Rec8p are required for cohesion between sister chromatids, for formation of axial elements, for reciprocal recombination, and for preventing hyperresection of double-strand breaks during meiosis [1].
Sequence similarity and testis-specific expression indicate evolutionarily conserved functions of Rec8p in meiosis [2].
We show at the protein level that expression of rec8 is meiosis specific and that Rec8p localizes to approximately 100 foci per prophase nucleus [2].
High mRNA expression of mouse and human rec8 genes was found only in germ line cells, specifically in testes and, interestingly, in spermatids. hrec8 was also expressed at a low level in the thymus [2].
During meiosis I, SGO2 accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres [3].

Biological context of REC8

We describe here the identification and characterisation of an Arabidopsis gene - DETERMINATE, INFERTILE1 (DIF1), which is a homolog of the Schizosaccharomyces pombe REC8/RAD21 cohesin genes, and is essential for meiotic chromosome segregation [4].
Alleles of afd1 dissect REC8 functions during meiotic prophase I [5].

Anatomical context of REC8

In normal and atretic human fetal oocytes, from leptotene to diplotene stages, REC8 and STAG3 colocalize in fibers [6].

References

A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Klein, F., Mahr, P., Galova, M., Buonomo, S.B., Michaelis, C., Nairz, K., Nasmyth, K. Cell (1999) [Pubmed]
Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. Parisi, S., McKay, M.J., Molnar, M., Thompson, M.A., van der Spek, P.J., van Drunen-Schoenmaker, E., Kanaar, R., Lehmann, E., Hoeijmakers, J.H., Kohli, J. Mol. Cell. Biol. (1999) [Pubmed]
Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis. Gómez, R., Valdeolmillos, A., Parra, M.T., Viera, A., Carreiro, C., Roncal, F., Rufas, J.S., Barbero, J.L., Suja, J.A. EMBO Rep. (2007) [Pubmed]
The DIF1 gene of Arabidopsis is required for meiotic chromosome segregation and belongs to the REC8/RAD21 cohesin gene family. Bhatt, A.M., Lister, C., Page, T., Fransz, P., Findlay, K., Jones, G.H., Dickinson, H.G., Dean, C. Plant J. (1999) [Pubmed]
Alleles of afd1 dissect REC8 functions during meiotic prophase I. Golubovskaya, I.N., Hamant, O., Timofejeva, L., Wang, C.J., Braun, D., Meeley, R., Cande, W.Z. J. Cell. Sci. (2006) [Pubmed]
Cohesin component dynamics during meiotic prophase I in mammalian oocytes. Prieto, I., Tease, C., Pezzi, N., Buesa, J.M., Ortega, S., Kremer, L., Martínez, A., Martínez-A, C., Hultén, M.A., Barbero, J.L. Chromosome Res. (2004) [Pubmed]

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