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Gene Review

TM9SF3  -  transmembrane 9 superfamily member 3

Homo sapiens

Synonyms: EP70-P-iso, SM-11044-binding protein, SMBP, Transmembrane 9 superfamily member 3, UNQ245/PRO282
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Disease relevance of TM9SF3

  • The correlation between the ratio of IGF-I to SMBP, which may reflect the IGF-I available to the placenta, to birth weight percentile was higher (r = 0.57), and the SE of estimate of weight percentile was 23% [1].
  • A higher affinity form of unsaturated SMBP is uniquely present in hypopituitarism and disappears with hGH treatment [2].

High impact information on TM9SF3


Anatomical context of TM9SF3

  • To characterize the macromolecular forms of somatomedin (SM) in human newborn plasma, we have studied the molecular weight distribution of endogenous SM peptides as well as the content and distribution of the acid-stable and the unsaturated SM-binding proteins (SMBP) in cord blood from 13 normal term infants [4].

Associations of TM9SF3 with chemical compounds


Analytical, diagnostic and therapeutic context of TM9SF3

  • Western blot experiments detected SMBP as a 70 kDa protein that may be further cleaved into an active 34 kDa N-terminal polypeptide [3].
  • Northern blot analysis revealed two major SMBP mRNAs, at 3.4 and 3.8 kb, that were present in all the human tissues examined [3].


  1. Serum levels of somatomedins and somatomedin-binding protein in pregnant women with type I or gestational diabetes and their infants. Hall, K., Hansson, U., Lundin, G., Luthman, M., Persson, B., Póvoa, G., Stangenberg, M., Ofverholm, U. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  2. Plasma somatomedin-binding proteins in hypopituitarism: changes during growth hormone therapy. Hintz, R.L., Liu, F., Rosenfeld, R.G., Kemp, S.F. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  3. The iodocyanopindolol and SM-11044 binding protein belongs to the TM9SF multispanning membrane protein superfamily. Sugasawa, T., Lenzen, G., Simon, S., Hidaka, J., Cahen, A., Guillaume, J.L., Camoin, L., Strosberg, A.D., Nahmias, C. Gene (2001) [Pubmed]
  4. Somatomedin peptide distribution and somatomedin-binding protein content in cord plasma: comparison to normal and hypopituitary plasma. Borsi, L., Rosenfeld, R.G., Liu, F., Hintz, R.L. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
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