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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nerve Regeneration

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Disease relevance of Nerve Regeneration


Psychiatry related information on Nerve Regeneration


High impact information on Nerve Regeneration


Chemical compound and disease context of Nerve Regeneration


Biological context of Nerve Regeneration


Anatomical context of Nerve Regeneration


Associations of Nerve Regeneration with chemical compounds

  • These data provide evidence that an integrin receptor functions in nerve regeneration in vivo [25].
  • The goal of this work was to improve the potential of fibrin to promote nerve regeneration by enzymatically incorporating exogenous neurite-promoting heparin-binding peptides [26].
  • During nerve regeneration, the relative proportion of nucleosides to nucleotides was reversed, with uridine being the principal labeled compound in the first case, and AMP, ADP, and ATP being the major labeled compounds in the latter case [27].
  • First, topical capsaicin application can produce a uniform epidermal nerve fibre injury that is safe and well tolerated, and offers an efficient strategy to measure and study nerve regeneration in man [28].
  • Abnormal nerve regeneration in galactose neuropathy [29].

Gene context of Nerve Regeneration


Analytical, diagnostic and therapeutic context of Nerve Regeneration


  1. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Sasahara, M., Fries, J.W., Raines, E.W., Gown, A.M., Westrum, L.E., Frosch, M.P., Bonthron, D.T., Ross, R., Collins, T. Cell (1991) [Pubmed]
  2. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Storkebaum, E., Lambrechts, D., Carmeliet, P. Bioessays (2004) [Pubmed]
  3. Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat. Stevens, M.J., Lattimer, S.A., Kamijo, M., Van Huysen, C., Sima, A.A., Greene, D.A. Diabetologia (1993) [Pubmed]
  4. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Sima, A.A., Calvani, M., Mehra, M., Amato, A. Diabetes Care (2005) [Pubmed]
  5. Induction of parathyroid hormone-related peptide following peripheral nerve injury: role as a modulator of Schwann cell phenotype. Macica, C.M., Liang, G., Lankford, K.L., Broadus, A.E. Glia (2006) [Pubmed]
  6. 2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats. Pan, K., Scott, M.K., Lee, D.H., Fitzpatrick, L.J., Crooke, J.J., Rivero, R.A., Rosenthal, D.I., Vaidya, A.H., Zhao, B., Reitz, A.B. Bioorg. Med. Chem. (2003) [Pubmed]
  7. Nogo in nerve regeneration. Goldberg, J.L., Barres, B.A. Nature (2000) [Pubmed]
  8. Forskolin activation of adenylate cyclase in vivo stimulates nerve regeneration. Kilmer, S.L., Carlsen, R.C. Nature (1984) [Pubmed]
  9. Apolipoprotein E, memory and Alzheimer's disease. Soininen, H.S., Riekkinen, P.J. Trends Neurosci. (1996) [Pubmed]
  10. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Wong, S.T., Henley, J.R., Kanning, K.C., Huang, K.H., Bothwell, M., Poo, M.M. Nat. Neurosci. (2002) [Pubmed]
  11. Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. Hirota, H., Kiyama, H., Kishimoto, T., Taga, T. J. Exp. Med. (1996) [Pubmed]
  12. p75 neurotrophin receptor induction and macrophage infiltration in peripheral nerve during experimental diabetic neuropathy: possible relevance on regeneration. Conti, G., Stoll, G., Scarpini, E., Baron, P.L., Bianchi, R., Livraghi, S., Scarlato, G. Exp. Neurol. (1997) [Pubmed]
  13. Amelioration of retarded neurite outgrowth of dorsal root ganglion neurons by overexpression of PKCdelta in diabetic rats. Sakaue, Y., Sanada, M., Sasaki, T., Kashiwagi, A., Yasuda, H. Neuroreport (2003) [Pubmed]
  14. Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes. Soneru, I.L., Khan, T., Orfalian, Z., Abraira, C. Endocr. Res. (1997) [Pubmed]
  15. GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Enomoto, H., Hughes, I., Golden, J., Baloh, R.H., Yonemura, S., Heuckeroth, R.O., Johnson, E.M., Milbrandt, J. Neuron (2004) [Pubmed]
  16. Nerve injury enhances rat neuronal glutamate transporter expression: identification by differential display PCR. Kiryu, S., Yao, G.L., Morita, N., Kato, H., Kiyama, H. J. Neurosci. (1995) [Pubmed]
  17. Successful storage of peripheral nerve before transplantation using green tea polyphenol: an experimental study in rats. Ikeguchi, R., Kakinoki, R., Okamoto, T., Matsumoto, T., Hyon, S.H., Nakamura, T. Exp. Neurol. (2003) [Pubmed]
  18. Transcriptional and post-transcriptional regulation of a brain growth protein: regional differentiation and regeneration induction of GAP-43. Namgung, U., Routtenberg, A. Eur. J. Neurosci. (2000) [Pubmed]
  19. Role of macrophage migration inhibitory factor (MIF) in peripheral nerve regeneration: anti-MIF antibody induces delay of nerve regeneration and the apoptosis of Schwann cells. Nishio, Y., Nishihira, J., Ishibashi, T., Kato, H., Minami, A. Mol. Med. (2002) [Pubmed]
  20. Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells. Saada, A., Reichert, F., Rotshenker, S. J. Cell Biol. (1996) [Pubmed]
  21. Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b. Sterne, G.D., Coulton, G.R., Brown, R.A., Green, C.J., Terenghi, G. J. Cell Biol. (1997) [Pubmed]
  22. Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration. Vyas, A.A., Patel, H.V., Fromholt, S.E., Heffer-Lauc, M., Vyas, K.A., Dang, J., Schachner, M., Schnaar, R.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  23. Cholesterol synthesis in regenerating peripheral nerve is not influenced by serum cholesterol levels. Goodrum, J.F. J. Neurochem. (1993) [Pubmed]
  24. Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. Suzuki, Y., Nakagomi, S., Namikawa, K., Kiryu-Seo, S., Inagaki, N., Kaibuchi, K., Aizawa, H., Kikuchi, K., Kiyama, H. J. Neurochem. (2003) [Pubmed]
  25. A dual laminin/collagen receptor acts in peripheral nerve regeneration. Toyota, B., Carbonetto, S., David, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  26. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. Sakiyama, S.E., Schense, J.C., Hubbell, J.A. FASEB J. (1999) [Pubmed]
  27. Axonal transport and transcellular transfer of nucleosides and polyamines in intact and regenerating optic nerves of goldfish: speculation on the axonal regulation of periaxonal cell metabolism. Ingoglia, N.A., Sharma, S.C., Pilchman, J., Baranowski, K., Sturman, J.A. J. Neurosci. (1982) [Pubmed]
  28. The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Polydefkis, M., Hauer, P., Sheth, S., Sirdofsky, M., Griffin, J.W., McArthur, J.C. Brain (2004) [Pubmed]
  29. Abnormal nerve regeneration in galactose neuropathy. Powell, H.C., Longo, F.M., LeBeau, J.M., Myers, R.R. J. Neuropathol. Exp. Neurol. (1986) [Pubmed]
  30. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients. Terrisse, L., Poirier, J., Bertrand, P., Merched, A., Visvikis, S., Siest, G., Milne, R., Rassart, E. J. Neurochem. (1998) [Pubmed]
  31. Regulation of the rat oligodendroglia cell line OLN-93 by antisense transfection of butyrylcholinesterase. Robitzki, A., Döll, F., Richter-Landsberg, C., Layer, P.G. Glia (2000) [Pubmed]
  32. Molecular structure and functional testing of human L1CAM: an interspecies comparison. Hlavin, M.L., Lemmon, V. Genomics (1991) [Pubmed]
  33. Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. Bajestan, S.N., Umehara, F., Shirahama, Y., Itoh, K., Sharghi-Namini, S., Jessen, K.R., Mirsky, R., Osame, M. J. Neurobiol. (2006) [Pubmed]
  34. Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation. Li, F., Carlsson, D., Lohmann, C., Suuronen, E., Vascotto, S., Kobuch, K., Sheardown, H., Munger, R., Nakamura, M., Griffith, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  35. Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats. Mizisin, A.P., Vu, Y., Shuff, M., Calcutt, N.A. Diabetes (2004) [Pubmed]
  36. Long acellular nerve transplants for allogeneic grafting and the effects of basic fibroblast growth factor on the growth of regenerating axons in dogs: a preliminary report. Ide, C., Tohyama, K., Tajima, K., Endoh, K., Sano, K., Tamura, M., Mizoguchi, A., Kitada, M., Morihara, T., Shirasu, M. Exp. Neurol. (1998) [Pubmed]
  37. Correlation between target reinnervation and distribution of motor axons in the injured rat sciatic nerve. Lago, N., Navarro, X. J. Neurotrauma (2006) [Pubmed]
  38. Presence of physiologically stimulated RET in adult rat brain: induction of RET expression during nerve regeneration. Colucci-D'Amato, G.L., D'Alessio, A., Filliatreau, G., Florio, T., Di Giamberardino, L., Chiappetta, G., Vecchio, G., Fusco, A., Santoro, M., de Franciscis, V. Cell Growth Differ. (1996) [Pubmed]
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