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Gene Review

MTUS1  -  microtubule associated tumor suppressor 1

Homo sapiens

Synonyms: AT2 receptor-binding protein, ATBP, ATIP, ATIP1, Angiotensin-II type 2 receptor-interacting protein, ...
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Disease relevance of MTUS1

  • Alongside monoclonal gammapathy of undetermined significance (MGUS) and monoclonal (B-cell) lymphocytosis of undetermined significance (MLUS), we propose using monoclonal T-cell dyscrasia of undetermined significance (MTUS) to underline a conceptual similarity between this disorder and the more common types of lymphocytic dyscrasia [1].
  • By PCR and cycle sequencing, we have determined the nucleotide sequences of the TK gene and the A-type inclusion protein (ATIP) gene of virus isolates from two human cowpox cases in Sweden, as well as a human and a feline case from Norway [2].

High impact information on MTUS1

  • The AT(2) receptor, MMS2, Src homology 2 domain-containing protein-tyrosine phosphatase 1 (SHP-1), and newly cloned AT(2) receptor-interacting protein (ATIP) were highly expressed in fetal rat neurons and declined after birth [3].
  • In their amino-terminal portion, ATIP polypeptides exhibit distinct motifs for localisation in the cytosol, nucleus or cell membrane, suggesting that MTUS1 gene products may be involved in a variety of intracellular functions in an AT2-dependent and independent manner [4].
  • The MTUS1 gene contains 17 coding exons distributed over 112 kb of genomic DNA [4].
  • The Mitochondrial Tumor suppressor 1 (MTUS1) gene is a newly identified candidate tumor suppressor gene at chromosomal position 8p22 [4].
  • Alternative exon usage generates three major transcripts (ATIP1, ATIP3 and ATIP4), each showing different tissue distribution [4].

Biological context of MTUS1

  • In this study, we assessed whether the angiotensin II AT2 receptor interacting protein (ATIP)/mitochondrial tumor suppressor gene (MTUS1), a gene newly identified at position 8p22, may be a candidate tumor suppressor gene mutated in HCC [5].
  • These results provide a new insight into the contribution of AT(2) receptor stimulation to neural differentiation via transactivation of MMS2 expression involving the association of ATIP and SHP-1 [3].
  • High evolutionary conservation of ATIP amino-acid sequences suggests important biological roles for this new family of proteins in tumor suppression and/or brain function [4].

Anatomical context of MTUS1

  • We searched for alterations in the 17 coding exons of ATIP/MTUS1 by means of denaturating high-performance liquid chromatography and sequencing, in 51 HCC tumors and 58 cell lines for which loss of heterozygosity status was known [5].
  • The condition may constitute a T cell counterpart to 'monoclonal gammopathy of undetermined significance' (MGUS), and by analogy we suggest it should be designated 'monoclonal T cell expansion of undetermined significance' (MTUS) [6].

Associations of MTUS1 with chemical compounds

  • We report here that MTUS1 encodes a family of proteins whose leader member (ATIP1) was previously isolated in our laboratory as a novel interacting partner of the angiotensin II AT2 receptor involved in growth inhibition (Nouet, JBC 279: 28989-97, 2004) [4].

Other interactions of MTUS1


Analytical, diagnostic and therapeutic context of MTUS1

  • The approaches used were (1) ATIP: anterior transthoracic in the fifth left intercostal space (Advanced Cardiac Life Support protocol), (2) SXP1: immediately subxiphoid and (3) SXP2: subxiphoid approach 1.5 cm inferior to SXP1 (Advanced Trauma Life Support protocol) [7].


  1. Monoclonal T-cell dyscrasia of undetermined significance associated with recalcitrant erythroderma. Gniadecki, R., Lukowsky, A. Archives of dermatology. (2005) [Pubmed]
  2. Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates. Hansen, H., Sandvik, T., Tryland, M., Olsvik, O., Traavik, T. APMIS (1999) [Pubmed]
  3. Angiotensin II-Induced Neural Differentiation via Angiotensin II Type 2 (AT2) Receptor-MMS2 Cascade Involving Interaction between AT2 Receptor-Interacting Protein and Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatase 1. Li, J.M., Mogi, M., Tsukuda, K., Tomochika, H., Iwanami, J., Min, L.J., Nahmias, C., Iwai, M., Horiuchi, M. Mol. Endocrinol. (2007) [Pubmed]
  4. Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. Di Benedetto, M., Bièche, I., Deshayes, F., Vacher, S., Nouet, S., Collura, V., Seitz, I., Louis, S., Pineau, P., Amsellem-Ouazana, D., Couraud, P.O., Strosberg, A.D., Stoppa-Lyonnet, D., Lidereau, R., Nahmias, C. Gene (2006) [Pubmed]
  5. Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. Di Benedetto, M., Pineau, P., Nouet, S., Berhouet, S., Seitz, I., Louis, S., Dejean, A., Couraud, P.O., Strosberg, A.D., Stoppa-Lyonnet, D., Nahmias, C. Mol. Cell. Endocrinol. (2006) [Pubmed]
  6. A persistent T cell expansion in the peripheral blood of a normal adult male: a new clinical entity? Grunewald, J., Jeddi-Tehrani, M., Dersimonian, H., Andersson, R., Wigzell, H. Clin. Exp. Immunol. (1992) [Pubmed]
  7. A cadaveric study of complications associated with the subxiphoid and transthoracic approaches to emergency pericardiocentesis. Kennedy, U.M., Mahony, N.J. European journal of emergency medicine : official journal of the European Society for Emergency Medicine. (2006) [Pubmed]
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