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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Lymphocytosis


High impact information on Lymphocytosis


Chemical compound and disease context of Lymphocytosis


Biological context of Lymphocytosis


Anatomical context of Lymphocytosis


Gene context of Lymphocytosis

  • However, the ADA activity and/or the ADA/PNP ratio were consistently higher in the cells from the patients with chronic T gamma lymphocytosis than in those with chronic T malignancy [11].
  • Polymorphism in BoLA-DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukemia virus [26].
  • Additionally, during persistent lymphocytosis, peak IL-2 and IL-10 mRNA expression was delayed, and elevated expression was prolonged [27].
  • All cases showed monoclonal CD5/CD19-positive lymphocytosis, with more than 10% large lymphocytes and/or prolymphocytes in peripheral blood smears and reactivity with FMC7, or bright expression of surface immunoglobulins in a fraction of the cases [28].
  • Although CCND1 expressing SLVL more commonly had marked lymphocytosis, they did not demonstrate a more aggressive clinical course than their negative counterparts, demonstrating that the detection of CCND1 expression or of a t(11;14) should not suffice to alter diagnostic classification in the absence of other criteria [29].

Analytical, diagnostic and therapeutic context of Lymphocytosis


  1. Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. Juliusson, G., Elmhorn-Rosenborg, A., Liliemark, J. N. Engl. J. Med. (1992) [Pubmed]
  2. CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection. Oksenhendler, E., Autran, B., Gorochov, G., D'Agay, M.F., Seligmann, M., Clauvel, J.P. Lancet (1992) [Pubmed]
  3. Granulated T cell lymphocytosis with neutropenia: malignant or benign chronic lymphoproliferative disorder? McKenna, R.W., Arthur, D.C., Gajl-Peczalska, K.J., Flynn, P., Brunning, R.D. Blood (1985) [Pubmed]
  4. Effects of recombinant interleukin-2 administration on cytotoxic function following high-dose chemo-radiotherapy for hematological malignancy. Gottlieb, D.J., Prentice, H.G., Heslop, H.E., Bello-Fernandez, C., Bianchi, A.C., Galazka, A.R., Brenner, M.K. Blood (1989) [Pubmed]
  5. TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo. Rho, J., Gong, S., Kim, N., Choi, Y. Mol. Cell. Biol. (2001) [Pubmed]
  6. Use of immunoglobulin gene rearrangements to show clonal lymphoproliferation in hyper-reactive malarial splenomegaly. Bates, I., Bedu-Addo, G., Bevan, D.H., Rutherford, T.R. Lancet (1991) [Pubmed]
  7. Enhanced and accelerated lymphoproliferation in Fas-null mice. Adachi, M., Suematsu, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T., Yoshida, N., Nagata, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Sympathetic and immune interactions during dynamic exercise. Mediation via a beta 2-adrenergic-dependent mechanism. Murray, D.R., Irwin, M., Rearden, C.A., Ziegler, M., Motulsky, H., Maisel, A.S. Circulation (1992) [Pubmed]
  9. Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and patients with congestive heart failure. Maisel, A.S., Harris, T., Rearden, C.A., Michel, M.C. Circulation (1990) [Pubmed]
  10. Phase I trial of interleukin-2 after unmodified HLA-matched sibling bone marrow transplantation for children with acute leukemia. Robinson, N., Sanders, J.E., Benyunes, M.C., Beach, K., Lindgren, C., Thompson, J.A., Appelbaum, F.R., Fefer, A. Blood (1996) [Pubmed]
  11. Enzyme analysis of lymphoproliferative diseases: a useful addition to cell surface phenotyping. van de Griend, R.J., van der Reijden, H.J., Bolhuis, R.L., Melief, C.J., von dem Borne, A.E., Roos, D. Blood (1983) [Pubmed]
  12. Development of leukemia and lymphosarcoma induced by bovine leukemia virus in sheep: a hematopathological study. Djilali, S., Parodi, A.L., Levy, D., Cockerell, G.L. Leukemia (1987) [Pubmed]
  13. Pulmonary sarcoidosis: role of CT in the evaluation of disease activity and functional impairment and in prognosis assessment. Remy-Jardin, M., Giraud, F., Remy, J., Wattinne, L., Wallaert, B., Duhamel, A. Radiology. (1994) [Pubmed]
  14. Mexiletine-induced severe skin eruption, fever, eosinophilia, atypical lymphocytosis, and liver dysfunction. Higa, K., Hirata, K., Dan, K. Pain (1997) [Pubmed]
  15. Evaluation of cyclosporine nephrotoxicity by renal transplant fine needle aspiration. Nast, C.C., Blifeld, C., Danovitch, G.M., Fine, R.N., Ettenger, R.B. Mod. Pathol. (1989) [Pubmed]
  16. Regulation of T cell homeostasis by heparan sulfate-bound IL-2. Wrenshall, L.E., Platt, J.L. J. Immunol. (1999) [Pubmed]
  17. An unusual form of persistent polyclonal B lymphocytosis in an infant. Gomez, P., Matutes, E., Sánchez, J., Garcia, J.M., Román, J., Gruszka-Westwood, A., Torres, A. Br. J. Haematol. (2000) [Pubmed]
  18. Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel. Stenfors, N., Nordenhäll, C., Salvi, S.S., Mudway, I., Söderberg, M., Blomberg, A., Helleday, R., Levin, J.O., Holgate, S.T., Kelly, F.J., Frew, A.J., Sandström, T. Eur. Respir. J. (2004) [Pubmed]
  19. Leukemic meningitis in a patient with splenic lymphoma with villous lymphocytes (SLVL). Meningitis as a possible initial manifestation of SLVL. Yamazaki, K., Shimizu, S., Negami, T., Sawada, K., Nanasawa, H., Ohta, M., Konda, S., Okuda, K. Cancer (1994) [Pubmed]
  20. Purification and immunological characterization of HPLC-purified pertussis toxin subunits. Chong, P., Cockle, S., Boux, H., Klein, M. Biochem. Cell Biol. (1991) [Pubmed]
  21. Phenotypic diversity of natural killer (NK) populations in patients with NK-type lymphoproliferative disease of granular lymphocytes. Zambello, R., Trentin, L., Ciccone, E., Bulian, P., Agostini, C., Moretta, A., Moretta, L., Semenzato, G. Blood (1993) [Pubmed]
  22. T cell receptor gene rearrangements define a monoclonal T cell proliferation in patients with T cell lymphocytosis and cytopenia. Berliner, N., Duby, A.D., Linch, D.C., Murre, C., Quertermous, T., Knott, L.J., Azin, T., Newland, A.C., Lewis, D.L., Galvin, M.C. Blood (1986) [Pubmed]
  23. Aicardi-Goutières syndrome: an update and results of interferon-alpha studies. Goutières, F., Aicardi, J., Barth, P.G., Lebon, P. Ann. Neurol. (1998) [Pubmed]
  24. Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells. Thompson, J.A., Lee, D.J., Lindgren, C.G., Benz, L.A., Collins, C., Shuman, W.P., Levitt, D., Fefer, A. Cancer Res. (1989) [Pubmed]
  25. The Aicardi-Goutières syndrome (familial, early onset encephalopathy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis). Tolmie, J.L., Shillito, P., Hughes-Benzie, R., Stephenson, J.B. J. Med. Genet. (1995) [Pubmed]
  26. Polymorphism in BoLA-DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukemia virus. Xu, A., van Eijk, M.J., Park, C., Lewin, H.A. J. Immunol. (1993) [Pubmed]
  27. B-lymphocyte proliferation during bovine leukemia virus-induced persistent lymphocytosis is enhanced by T-lymphocyte-derived interleukin-2. Trueblood, E.S., Brown, W.C., Palmer, G.H., Davis, W.C., Stone, D.M., McElwain, T.F. J. Virol. (1998) [Pubmed]
  28. Chromosome aberrations in atypical chronic lymphocytic leukemia: a cytogenetic and interphase cytogenetic study. Bigoni, R., Cuneo, A., Roberti, M.G., Bardi, A., Rigolin, G.M., Piva, N., Scapoli, G., Spanedda, R., Negrini, M., Bullrich, F., Veronese, M.L., Croce, C.M., Castoldi, G. Leukemia (1997) [Pubmed]
  29. Genetic analysis of splenic lymphoma with villous lymphocytes: a Groupe Français d'Hématologie Cellulaire (GFHC) study. Troussard, X., Mauvieux, L., Radford-Weiss, I., Rack, K., Valensi, F., Garand, R., Vekemans, M., Flandrin, G., Macintyre, E.A. Br. J. Haematol. (1998) [Pubmed]
  30. Colonic histopathology in untreated celiac sprue or refractory sprue: is it lymphocytic colitis or colonic lymphocytosis? Fine, K.D., Lee, E.L., Meyer, R.L. Hum. Pathol. (1998) [Pubmed]
  31. Mantle cell lymphoma, in leukaemic phase with prominent splenomegaly. A report of eight cases with similar clinical presentation and aggressive outcome. Molina, T.J., Delmer, A., Cymbalista, F., Le Tourneau, A., Perrot, J.Y., Ramond, S., Marie, J.P., Audouin, J., Zittoun, R., Diebold, J. Virchows Arch. (2000) [Pubmed]
  32. Analysis of antibody profiles in children with whooping cough. Novotny, P., Macaulay, M.E., Hart, T.C., Skvaril, F. Dev. Biol. Stand. (1991) [Pubmed]
  33. Invasive thymoma with CD4+CD8+ double-positive T cell lymphocytosis. Tamaoki, J., Chiyotani, A., Nagai, A., Konno, K. Respiration; international review of thoracic diseases. (1997) [Pubmed]
  34. Presence of clonal T-cell receptor gene rearrangements provides evidence of widespread intramucosal intestinal T-cell lymphoma. Schmitt-Gräff, A., Daum, S., Hummel, M., Zemlin, M., Stein, H., Riecken, E.O. Zeitschrift für Gastroenterologie. (1996) [Pubmed]
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